About: Involvement of Spike Protein, Furin, and ACE2 in SARS-CoV-2-Related Cardiovascular Complications

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About: Involvement of Spike Protein, Furin, and ACE2 in SARS-CoV-2-Related Cardiovascular Complications Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Involvement of Spike Protein, Furin, and ACE2 in SARS-CoV-2-Related Cardiovascular Complications
Creator	Qiang, Liu Ming, Yi
Source	Medline; PMC
abstract	The novel coronavirus disease 2019 (COVID-19) is a global epidemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). SARS-CoV-2 has a similar structure to severe acute respiratory syndrome coronavirus-1(SARS-CoV-1). The S protein on the surface of the virus is cleaved by host proprotein convertases (PCs) to expose the active N-terminal S1 extracellular domain. Its receptors are angiotensin-converting enzyme 2 (ACE2), and the C-terminal S2 membrane anchoring protein is responsible for translocating the virus into the cell. Among patients with COVID-19, there is a higher prevalence of cardiovascular disease, and more than 7% of patients have suffered myocardial damage due to the infection, but the internal mechanism is still poorly understood. There is currently no specific and effective targeted treatment. Reduction of the patient’s morbidity and mortality is an urgent problem that needs to be solved clinically. By exploring the theoretical analysis of PCs and ACE2 in COVID-19 cardiovascular susceptibility, some insights on how to prevent and alleviate adverse cardiovascular prognosis have been provided in this study.
has issue date	2020-07-11(xsd:dateTime)
bibo:doi	10.1007/s42399-020-00400-2
bibo:pmid	32838164
has license	no-cc
sha1sum (hex)	e0e9b9f9f0bb12e24233d62ce99655baee5c20ee
schema:url	https://doi.org/10.1007/s42399-020-00400-2
resource representing a document's title	Involvement of Spike Protein, Furin, and ACE2 in SARS-CoV-2-Related Cardiovascular Complications
has PubMed Central identifier	PMC7352091
has PubMed identifier	32838164
schema:publication	SN Compr Clin Med
resource representing a document's body	covid:e0e9b9f9f0bb12e24233d62ce99655baee5c20ee#body_text
is schema:about of	named entity 'expose' named entity 'epidemic' named entity 'PCs' named entity 'ANGIOTENSIN-CONVERTING ENZYME 2' named entity 'HOW' named entity 'EXPOSE' named entity 'EPIDEMIC' named entity 'protein' named entity 'severe acute respiratory syndrome coronavirus' named entity 'active' named entity 'patient' named entity 'receptors' named entity 'PCs' named entity 'protein' named entity 'susceptibility' named entity 'caused' named entity 'anchoring' named entity 'internal' named entity 'myocardial' named entity 'mortality' named entity 'solved' named entity 'ACE2' named entity 'ACE2' named entity 'protein' named entity 'SARS-CoV-2' named entity 'SARS-CoV-1' named entity 'protein' named entity 'N-terminal' named entity 'Cardiovascular Complications' named entity 'angiotensin II' named entity 'binding domain' named entity 'pathological process' named entity 'SARS-CoV-2' named entity 'crystal structure' named entity 'RBD' named entity 'acute lung injury' named entity 'heart failure' named entity 'Proprotein convertases' named entity 'Furin' named entity 'Shenzhen' named entity 'cardiovascular events' named entity 'cell surface receptors' named entity 'Hypertension' named entity 'Liu Qiang' named entity 'chronic kidney disease' named entity 'antiviral effect' named entity 'ACEi' named entity 'protein' named entity 'proprotein convertase' named entity 'granule' named entity 'ACE2' named entity 'Severe acute respiratory syndrome coronavirus' named entity 'SARS-CoV-2' named entity 'metabolic diseases' named entity 'ACE2 receptor' named entity '1, 2' named entity 'Topical Collection' named entity 'translocation' named entity 'lopinavir' named entity 'biological processes' named entity 'coronavirus' named entity 'SARS-CoV-2' named entity 'host cells' named entity 'protein cleavage' named entity 'viral replication' named entity 'severe infections' named entity 'Lys' named entity 'cardiovascular disease' named entity 'COVID' named entity 'ACE2' named entity 'virus' named entity 'amino acids' named entity '95% CI' named entity 'clinical trials' named entity 'furin' named entity 'heart failure' named entity 'amino acids' named entity 'COVID' named entity 'Center for Disease Control and Prevention' named entity 'SARS-CoV-1'

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