About: Respiratory Virus Detection and Clinical Diagnosis in Children Attending Day Care

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Respiratory Virus Detection and Clinical Diagnosis in Children Attending Day Care
Creator	Døllner, Henrik Krokstad, Sidsel Moe, Nina Pedersen, Bård Smyrnaios, Anastasios Nordbø, Svein Skanke, Lars
source	Medline; PMC
abstract	BACKGROUND: Respiratory viruses often have been studied in children with respiratory tract infection (RTI), but less knowledge exists about viruses in asymptomatic children. We have studied the occurrence of a broad panel of respiratory viruses in apparently healthy children attending day care, taking into account the influence of possible confounding factors, such as age, clinical signs of respiratory tract infection (RTI), location (day-care section) and season. METHODS: We have studied 161 children in two day-care centers, each with separate sections for younger and older children, during four autumn and winter visits over a two-year period. A total of 355 clinical examinations were performed, and 343 nasopharyngeal samples (NPS) were analyzed by semi-quantitative, real-time, polymerase chain reaction (PCR) tests for 19 respiratory pathogens. RESULT: Forty-three percent of all NPS were PCR-positive for ≥ 1 of 13 virus species, with high species variation during visits. Rhinovirus 26% (88/343 NPS), enterovirus 12% (40/343) and parechovirus 9% (30/343) were detected in every visit, and the rates varied in relation to age, day-care section and season. Ten other viruses were detected in ≤ 3% of the NPS. Generally, viruses occurred together in the NPS. In 24% (79/331) of the clinical examinations with available NPS, the children had clear signs of RTI, while in 41% (135/331) they had mild signs, and in 35% (117/331) the children had no signs of RTI. Moreover, viruses were found in 70% (55/79) of children with clear signs of RTI, in 41% (55/135) with mild signs and in 30% (35/117) without any signs of RTI (p < 0.001). CONCLUSIONS: Positive PCR tests for respiratory viruses, particularly picornaviruses, were frequently detected in apparently healthy children attending day care. Virus detection rates were related to age, presence of clinical signs of RTI, location in day care and season.
has issue date	2016-07-19(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0159196
bibo:pmid	27433803
has license	cc-by
sha1sum (hex)	e0f39f2d61d66f276287f181454ae85cdafb7ffa
schema:url	https://doi.org/10.1371/journal.pone.0159196
resource representing a document's title	Respiratory Virus Detection and Clinical Diagnosis in Children Attending Day Care
has PubMed Central identifier	PMC4951077
has PubMed identifier	27433803
schema:publication	PLoS One
resource representing a document's body	covid:e0f39f2d61d66f276287f181454ae85cdafb7ffa#body_text
is schema:about of	named entity 'season' named entity 'viruses' named entity 'LOCATION' named entity 'AGE' named entity 'PANEL' named entity 'DAY CARE' named entity 'CHILDREN' named entity 'ACCOUNT' named entity 'ATTENDING' named entity 'INFLUENCE' named entity 'OCCURRENCE' named entity 'ASYMPTOMATIC' named entity 'ABOUT' named entity 'POSSIBLE' named entity 'HAVE' named entity 'CONFOUNDING FACTORS' named entity 'SEASON' named entity 'HEALTHY' named entity 'SECTION' named entity 'CHILDREN' named entity 'CLINICAL DIAGNOSIS' named entity 'RESPIRATORY TRACT INFECTION' named entity 'BUT' named entity 'KNOWLEDGE' named entity 'BROAD' named entity 'RESPIRATORY VIRUS' named entity 'RESPIRATORY VIRUSES' named entity 'VIRUSES' named entity 'TAKING' named entity 'VIRUS DETECTION' named entity 'DAY CARE' named entity 'ATTENDING' named entity 'CARE' named entity 'APPARENTLY' covid:arg/e0f39f2d61d66f276287f181454ae85cdafb7ffa named entity 'RTI' named entity 'asymptomatic' named entity 'respiratory tract' named entity 'respiratory tract' named entity 'Respiratory' named entity 'location' named entity 'viruses' named entity 'day care' named entity 'viruses' named entity 'respiratory tract infection' named entity 'Virus' named entity 'Clinical Diagnosis' named entity 'virus' named entity 'tonsillitis' named entity 'picornaviruses' named entity 'RTI' named entity 'null hypothesis' named entity 'viruses' named entity 'viruses' named entity 'RTI' named entity 'day-care centers' named entity '229E' named entity 'asymptomatic infection' named entity 'Chlamydophila pneumoniae' named entity 'Model selection' named entity 'HRV' named entity 'viruses' named entity 'RTI' named entity 'respiratory syncytial virus' named entity 'RTI' named entity 'Kruskal-Wallis test' named entity 'RTI' named entity 'virus' named entity 'logit' named entity 'viruses' named entity 'Norwegian' named entity 'HRV' named entity 'respiratory tract infection' named entity 'z-test' named entity 'binary variable'

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