About: A divergent cyclin/cyclin-dependent kinase complex controls the atypical replication of a malaria parasite during gametogony and transmission

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About: A divergent cyclin/cyclin-dependent kinase complex controls the atypical replication of a malaria parasite during gametogony and transmission Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	A divergent cyclin/cyclin-dependent kinase complex controls the atypical replication of a malaria parasite during gametogony and transmission
Creator	Mourier, Tobias Ferguson, David Pain, Arnab Pandey, Rajan Arboit, Patrizia Auré, Lia Balestra, Brady, Declan Brochet, Mathieu Brusini, Lorenzo Hainard, Alexandre Holder, Anthony Klages, Natacha Pasquarello, Carla Rea, Edward Subudhi, Amit Tewari, Rita Vaughan, Sue Zeeshan, Mohammad
source	PMC
abstract	Cell cycle transitions are generally triggered by variation in the activity of cyclin-dependent kinases (CDKs) bound to cyclins. Malaria-causing parasites have a life cycle with unique cell-division cycles, and a repertoire of divergent CDKs and cyclins of poorly understood function and interdependency. We show that Plasmodium berghei CDK-related kinase 5 (CRK5), is a critical regulator of atypical mitosis in the gametogony and is required for mosquito transmission. It phosphorylates canonical CDK motifs of components in the pre-replicative complex and is essential for DNA replication. During a replicative cycle, CRK5 stably interacts with a single Plasmodium-specific cyclin (SOC2), although we obtained no evidence of SOC2 cycling by transcription, translation or degradation. Our results provide evidence that during Plasmodium male gametogony, this divergent cyclin/CDK pair fills the functional space of other eukaryotic cell-cycle kinases controlling DNA replication.
has issue date	2020-06-22(xsd:dateTime)
bibo:doi	10.7554/elife.56474
has license	cc-by
sha1sum (hex)	e1034696345b844f579d44624719ce2d31650245
schema:url	https://doi.org/10.7554/elife.56474
resource representing a document's title	A divergent cyclin/cyclin-dependent kinase complex controls the atypical replication of a malaria parasite during gametogony and transmission
has PubMed Central identifier	PMC7308089
resource representing a document's body	covid:e1034696345b844f579d44624719ce2d31650245#body_text
is schema:about of	named entity 'cycles' named entity 'replicative' named entity 'controlling' named entity 'cyclin' named entity 'During' named entity 'UNIQUE CELL' named entity 'TRANSCRIPTION' named entity 'REQUIRED' named entity 'MOSQUITO' named entity 'MOTIFS' named entity 'DOI' named entity 'ORG' named entity 'PRE-REPLICATIVE COMPLEX' named entity 'TRIGGERED BY' named entity 'LIFE CYCLE' named entity 'OBTAINED' named entity 'cyclins' named entity 'gametogony' named entity 'DOI' named entity 'kinases' named entity 'male' named entity 'essential' named entity 'ARTICLE' named entity 'Cell cycle' named entity 'transmission' named entity 'function' named entity 'cyclin-dependent kinase' named entity 'complex' named entity 'kinases' named entity 'parasites' named entity 'CDK' named entity 'eLife' named entity 'kinases' named entity 'CDK' named entity 'CDKs' named entity 'Plasmodium' named entity 'cell-division' named entity 'phosphorylates' named entity 'doi' named entity 'cyclin' named entity 'gametogony' named entity 'interdependency' named entity 'GFP' named entity 'ANOVA' named entity 'cloned' named entity 'midgut' named entity 'origin recognition complex' named entity 'RNA' named entity 'phosphorylation sites' named entity 'morphologically' named entity 'kinases' named entity '99.9%' named entity 'co-purified' named entity 'primer pairs' named entity 'epithelium' named entity 'NotI' named entity 'fluorescence microscopy' named entity 'protein' named entity 'mice' named entity 'GraphPad Prism' named entity 'TMT' named entity 'cyclins' named entity 'CDK' named entity 'Thermo Fisher Scientific' named entity 'Peptide' named entity 'epitope tag'

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