About: Tissue Distribution of the MERS-Coronavirus Receptor in Bats

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Tissue Distribution of the MERS-Coronavirus Receptor in Bats
Creator	Reusken, Chantal Begeman, Lineke Kley, Nils Schipper, Debby Haagmans, Bart Cunningham, Andrew Van Den Brand, Judith Widagdo, W Van Run, Peter
Source	Medline; PMC
abstract	Middle East respiratory syndrome coronavirus (MERS-CoV) has been shown to infect both humans and dromedary camels using dipeptidyl peptidase-4 (DPP4) as its receptor. The distribution of DPP4 in the respiratory tract tissues of humans and camels reflects MERS-CoV tropism. Apart from dromedary camels, insectivorous bats are suggested as another natural reservoir for MERS-like-CoVs. In order to gain insight on the tropism of these viruses in bats, we studied the DPP4 distribution in the respiratory and extra-respiratory tissues of two frugivorous bat species (Epomophorus gambianus and Rousettus aegyptiacus) and two insectivorous bat species (Pipistrellus pipistrellus and Eptesicus serotinus). In the frugivorous bats, DPP4 was present in epithelial cells of both the respiratory and the intestinal tract, similar to what has been reported for camels and humans. In the insectivorous bats, however, DPP4 expression in epithelial cells of the respiratory tract was almost absent. The preferential expression of DPP4 in the intestinal tract of insectivorous bats, suggests that transmission of MERS-like-CoVs mainly occurs via the fecal-oral route. Our results highlight differences in the distribution of DPP4 expression among MERS-CoV susceptible species, which might influence variability in virus tropism, pathogenesis and transmission route.
has issue date	2017-04-26(xsd:dateTime)
bibo:doi	10.1038/s41598-017-01290-6
bibo:pmid	28446791
has license	cc-by
sha1sum (hex)	e10eb45af8825e380c4c7df28487b597f2b0402e
schema:url	https://doi.org/10.1038/s41598-017-01290-6
resource representing a document's title	Tissue Distribution of the MERS-Coronavirus Receptor in Bats
has PubMed Central identifier	PMC5430768
has PubMed identifier	28446791
schema:publication	Sci Rep
resource representing a document's body	covid:e10eb45af8825e380c4c7df28487b597f2b0402e#body_text
is schema:about of	named entity 'frugivorous' named entity 'expression' named entity 'distribution' named entity 'Receptor' covid:arg/e10eb45af8825e380c4c7df28487b597f2b0402e named entity 'species' named entity 'preferential' named entity 'Eptesicus' named entity 'insectivorous bats' named entity 'humans' named entity 'receptor' named entity 'viruses' named entity 'bats' named entity 'tissues' named entity 'respiratory tract' named entity 'DPP4' named entity 'DPP4' named entity 'epithelial cells' named entity 'Epomophorus gambianus' named entity 'Receptor' named entity 'Tissue Distribution' named entity 'cloned' named entity 'bat species' named entity 'Egyptian fruit bat' named entity 'bat' named entity 'MERS-CoV' named entity 'common pipistrelle' named entity 'human intestine' named entity 'dromedary camel' named entity 'virus' named entity 'epithelium' named entity 'Egyptian' named entity 'fruit bats' named entity 'DPP4' named entity 'apical surface' named entity 'MERS-CoV' named entity 'fruit bat' named entity 'epithelial cells' named entity 'common pipistrelle bat' named entity 'Santa Ana' named entity 'epithelial cells' named entity 'paraffin' named entity 'fruit bats' named entity 'MERS' named entity 'insectivorous bats' named entity 'apical surface' named entity 'staining' named entity 'bat species' named entity 'antibody' named entity 'MERS-CoV' named entity 'serotine bat' named entity 'respiratory tract' named entity 'fruit bat' named entity 'lungs' named entity 'submucosal glands' named entity 'lung' named entity 'serotine bat' named entity 'insectivorous bats' named entity 'respiratory tract' named entity 'MERS-CoV' named entity 'faecal samples' named entity 'alveolar epithelial cells' named entity 'intestine' named entity 'Fig' named entity 'respiratory tract' named entity 'intestine' named entity 'MERS' named entity 'paraffin' named entity 'titration' named entity 'common pipistrelle bat' named entity 'livestock' named entity 'virus' named entity 'MERS-CoV'

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