About: Limiting respiratory viral infection by targeting antiviral and immunological functions of BST-2/Tetherin: Knowledge and gaps

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Limiting respiratory viral infection by targeting antiviral and immunological functions of BST-2/Tetherin: Knowledge and gaps
Creator	Su, Alvin Berry, Kayla Brett, Tom Kober, Daniel
source	Medline; PMC
abstract	Recent findings regarding the cellular biology and immunology of BST-2 (also known as tetherin) indicate that its function could be exploited as a universal replication inhibitor of enveloped respiratory viruses (e.g., influenza, respiratory syncytial virus, etc.). BST-2 inhibits viral replication by preventing virus budding from the plasma membrane and by inducing an antiviral state in cells adjacent to infection via unique inflammatory signaling mechanisms. This review presents the first comprehensive summary of what is currently known about BST-2 antiviral function against respiratory viruses, how these viruses construct countermeasures to antagonize BST-2, and how BST-2 function might be targeted to develop therapies to treat respiratory virus infections. We address the current gaps in knowledge, including the need for mechanistic understanding of BST-2 antagonism by respiratory viruses, that should be bridged to achieve that goal.
has issue date	2018-08-16(xsd:dateTime)
bibo:doi	10.1002/bies.201800086
bibo:pmid	30113067
has license	bronze-oa
sha1sum (hex)	e11e45d09723242760d242a3b5ae926c2c1dd961
schema:url	https://doi.org/10.1002/bies.201800086
resource representing a document's title	Limiting respiratory viral infection by targeting antiviral and immunological functions of BST-2/Tetherin: Knowledge and gaps
has PubMed Central identifier	PMC6371793
has PubMed identifier	30113067
schema:publication	BioEssays
resource representing a document's body	covid:e11e45d09723242760d242a3b5ae926c2c1dd961#body_text
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