About: Rhinovirus-Infected Epithelial Cells Produce More IL-8 and RANTES Compared With Other Respiratory Viruses

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Rhinovirus-Infected Epithelial Cells Produce More IL-8 and RANTES Compared With Other Respiratory Viruses
Creator	Lee, Hyun Kim, Jin Kim, Hyun Yoon, Lee, Joon Chun, Ju Chung, Jong-Seo Joe, Jin Kim, Sulmui Park, Huisu Won, Hyun Yoon, Hong
source	Medline; PMC
abstract	PURPOSE: The environmental factors human rhinoviruses (HRVs) and house dust mites (HDMs) are the most common causes of acute exacerbations of asthma. The aim of this study was to compare the chemokine production induced by HRVs in airway epithelial cells with that induced by other respiratory viruses, and to investigate synergistic interactions between HRVs and HDMs on the induction of inflammatory chemokines in vitro. METHODS: A549 human airway epithelial cells were infected with either rhinovirus serotype 7, respiratory syncytial virus (RSV)-A2 strain, or adenovirus serotype 3 and analyzed for interleukin (IL)-8 and regulated on activation, normal T-cell expressed and secreted (RANTES) release and mRNA expression. Additionally, activation of nuclear factor (NF)-κB and activator protein (AP)-1 were evaluated. The release of IL-8 and RANTES was also measured in cells stimulated simultaneously with a virus and the HDM allergen, Der f1. RESULTS: HRV caused greater IL-8 and RANTES release and mRNA expression compared with either RSV or adenovirus. NF-κB and AP-1 were activated in these processes. Cells incubated with a virus and Der f1 showed an increased IL-8 release. However, compared with cells incubated with virus alone as the stimulator, only HRV with Der f1 showed a statistically significant increase. CONCLUSIONS: IL-8 and RANTES were induced to a greater extent by HRV compared with other viruses, and only HRV with Der f1 acted synergistically to induce bronchial epithelial IL-8 release. These findings may correspond with the fact that rhinoviruses are identified more frequently than other viruses in cases of acute exacerbation of asthma.
has issue date	2013-05-27(xsd:dateTime)
bibo:doi	10.4168/aair.2013.5.4.216
bibo:pmid	23814675
has license	cc-by-nc
sha1sum (hex)	e11faf6356de98196a3566fa0755f178909b256d
schema:url	https://doi.org/10.4168/aair.2013.5.4.216
resource representing a document's title	Rhinovirus-Infected Epithelial Cells Produce More IL-8 and RANTES Compared With Other Respiratory Viruses
has PubMed Central identifier	PMC3695236
has PubMed identifier	23814675
schema:publication	Allergy Asthma Immunol Res
resource representing a document's body	covid:e11faf6356de98196a3566fa0755f178909b256d#body_text
is schema:about of	named entity 'house dust mite' named entity 'factors' named entity 'dust mite' named entity 'mediators' named entity 'AIRWAY' covid:arg/e11faf6356de98196a3566fa0755f178909b256d named entity 'HDM' named entity 'exacerbation' named entity 'allergen' named entity 'With' named entity 'Epithelial' named entity 'viruses' named entity 'Arg' named entity 'HDM' named entity 'Glu' named entity 'house dust mite' named entity 'aeroallergens' named entity 'allergen' named entity 'wheezing' named entity 'Viruses' named entity 'CO2' named entity 'RANTES' named entity 'infection' named entity 'RANTES' named entity 'neutrophils' named entity 'IL-8' named entity 'CO2' named entity 'HeLa cells' named entity 'RANTES' named entity 'adenovirus' named entity 'RANTES' named entity 'rhinovirus' named entity 'thermal cycler' named entity 'sputum' named entity 'adenovirus' named entity 'virus-mediated' named entity 'allergen' named entity 'allergen' named entity 'rhinovirus' named entity 'NF-κB' named entity 'RSV' named entity 'NF-κB' named entity 'virus' named entity 'upper respiratory tract' named entity 'NF-κB' named entity 'FBS' named entity 'asthma exacerbation' named entity 'chemokine' named entity 'housekeeping gene' named entity 'IL-8' named entity 'cytokines' named entity 'virus' named entity 'Phosphorylated' named entity 'adenovirus' named entity 'HRV' named entity 'IL-8' named entity 'rhinovirus' named entity 'chemokines' named entity 'RSV' named entity 'adenovirus' named entity 'Neutrophil' named entity 'allergic sensitization' named entity 'alveolar epithelial cells' named entity 'RANTES' named entity 'adenovirus' named entity 'chemokines' named entity 'IFN-γ' named entity 'HEPES' named entity 'IL-8' named entity 'β-actin'

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