About: A Novel Pathogenic Mammalian Orthoreovirus from Diarrheic Pigs and Swine Blood Meal in the United States

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About: A Novel Pathogenic Mammalian Orthoreovirus from Diarrheic Pigs and Swine Blood Meal in the United States Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A Novel Pathogenic Mammalian Orthoreovirus from Diarrheic Pigs and Swine Blood Meal in the United States
Creator	Elankumaran, Subbiah Cao, Dianjun Meng, Xiang-Jin Deventhiran, Jagadeeswaran Hall, Karen Jobst, Peter Kambiranda, Devaiah Lindstrom, Nicole Sexton, Cary Sooryanarain, Harini Thimmasandra Narayanappa, Athmaram Griffin, Diane Hopkins Bloomberg, Johns Leroith, Tanya Heffron, Connie Venkatachalam, Backiyalakshmi
Source	Medline; PMC
abstract	Since May 2013, outbreaks of porcine epidemic diarrhea have devastated the U.S. swine industry, causing immense economic losses. Two different swine enteric coronaviruses (porcine epidemic diarrhea virus and Delta coronavirus) have been isolated from the affected swine population. The disease has been reported from at least 32 states of the United States and other countries, including Mexico, Peru, Dominican Republic, Canada, Columbia, Ecuador, and Ukraine, with repeated outbreaks in previously infected herds. Here we report the isolation and characterization of a novel mammalian orthoreovirus 3 (MRV3) from diarrheic feces of piglets from these outbreaks in three states and ring-dried swine blood meal from multiple sources. MRV3 could not be isolated from healthy or pigs that had recovered from epidemic diarrhea from four states. Several MRV3 isolates were obtained from chloroform-extracted pig feces or blood meal in cell cultures or developing chicken embryos. Biological characterization of two representative isolates revealed trypsin resistance and thermostability at 90°C. NextGen sequencing of ultrapurified viruses indicated a strong homology of the S1 segment to mammalian and bat MRV3. Neonatal piglets experimentally infected with these viruses or a chloroform extract of swine blood meal developed severe diarrhea and acute gastroenteritis with 100% mortality within 3 days postinfection. Therefore, the novel porcine MRV3 may contribute to enteric disease along with other swine enteric viruses. The role of MRV3 in the current outbreaks of porcine epidemic diarrhea in the United States remains to be determined, but the pathogenic nature of the virus warrants further investigations on its epidemiology and prevalence.
has issue date	2015-05-19(xsd:dateTime)
bibo:doi	10.1128/mbio.00593-15
bibo:pmid	25991685
has license	cc-by-nc-sa
sha1sum (hex)	e1253d2bfe05e4fa4a42f9a542ca45c32a1e2264
schema:url	https://doi.org/10.1128/mbio.00593-15
resource representing a document's title	A Novel Pathogenic Mammalian Orthoreovirus from Diarrheic Pigs and Swine Blood Meal in the United States
has PubMed Central identifier	PMC4442135
has PubMed identifier	25991685
schema:publication	mBio
resource representing a document's body	covid:e1253d2bfe05e4fa4a42f9a542ca45c32a1e2264#body_text
is schema:about of	named entity 'DRIED' named entity 'REPORT' named entity 'BUT' named entity 'TRYPSIN' named entity 'SEVERE DIARRHEA' named entity 'NOVEL' named entity 'THERMOSTABILITY' named entity 'PERU' named entity 'DIFFERENT' named entity 'SWINE' named entity 'SOURCES' named entity 'PIGS' named entity 'HEALTHY' named entity 'THESE' named entity 'NEONATAL' named entity 'U.S.' named entity 'CORONAVIRUS' named entity 'EPIDEMIC DIARRHEA' named entity 'PIG' named entity 'UKRAINE' named entity 'INFECTED' named entity 'Here' named entity 'chloroform' named entity 'enteric' named entity 'viruses' named entity 'determined' named entity 'swine' named entity 'developing' named entity 'epidemiology' named entity 'swine' covid:arg/e1253d2bfe05e4fa4a42f9a542ca45c32a1e2264 named entity 'STATES' named entity 'ITS' named entity 'BIOLOGICAL' named entity 'DISEASE' named entity 'INDUSTRY' named entity 'CANADA' named entity 'RESISTANCE' named entity 'NEXTGEN SEQUENCING' named entity 'EPIDEMIOLOGY' named entity 'HAVE' named entity 'REPEATED' named entity 'CHARACTERIZATION' named entity 'PATHOGENIC' named entity 'SWINE' named entity 'PIGS' named entity 'UNITED STATES' named entity 'NOVEL' named entity 'S1 SEGMENT' named entity 'HOMOLOGY' named entity 'OUTBREAKS' named entity 'EXTRACT' named entity 'PATHOGENIC' named entity 'MULTIPLE' named entity 'COLUMBIA' named entity 'FECES' named entity 'INVESTIGATIONS' named entity 'UNITED STATES' named entity 'INDICATED' named entity 'BLOOD MEAL' named entity 'CHLOROFORM' named entity 'MEXICO' named entity 'COUNTRIES' named entity 'HERE' named entity 'EXTRACTED' named entity 'RECOVERED'

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