About: ACE2 Expression is elevated in Airway Epithelial Cells from aged and male donors but reduced in asthma

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About: ACE2 Expression is elevated in Airway Epithelial Cells from aged and male donors but reduced in asthma Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	ACE2 Expression is elevated in Airway Epithelial Cells from aged and male donors but reduced in asthma
Creator	Chen, Ling Wark, Peter Kicic, Anthony Stick, Stephen Reid, Andrew Veerati, Punnam Bartlett, Nathan Pathinayake, Prabuddha Hansbro, Philip Nichol, Kristy Garratt, Luke Ali, Ayesha Eapen, Mathew Hsu, Alan C-Y Iosifidis, Thomas Kaiko, Gerard Looi, Kevin Lu, Wenying Oldmeadow, Christopher Peter, Prof Sohal, Sukhwinder Sutanto, Erika Wark, A
Source	MedRxiv
abstract	Rationale: COVID-19 is complicated by acute lung injury, and death in some individuals. It is caused by SARS-CoV-2 that requires the ACE2 receptor and serine proteases to enter airway epithelial cells (AECs). Objective: To determine what factors are associated with ACE2 expression particularly in patients with asthma and chronic obstructive pulmonary disease (COPD). Methods: We obtained upper and lower AECs from 145 people from two independent cohorts, aged 2-89, Newcastle (n=115), and from Perth (n= 30) Australia. The Newcastle cohort was enriched with people with asthma (n=37) and COPD (n=38). Gene expression for ACE2 and other genes potentially associated with SARS-CoV-2 cell entry were assessed by quantitative PCR, protein expression was confirmed with immunohistochemistry on endobronchial biopsies and cultured AECs. Results: Increased gene expression of ACE2 was associated with older age (p=0.02) and male sex (p=0.03), but not pack-years smoked. When we compared gene expression between adults with asthma, COPD and healthy controls, mean ACE2 expression was lower in asthma (p=0.01). Gene expression of furin, a protease that facilitates viral endocytosis, was also lower in asthma (p=0.02), while ADAM-17, a disintegrin that cleaves ACE2 from the surface was increased (p=0.02). ACE2 protein levels were lower in endobronchial biopsies from asthma patients. Conclusions: Increased ACE2 expression occurs in older people and males. Asthma patients have reduced expression. Altered ACE2 expression in the lower airway may be an important factor in virus tropism and may in part explain susceptibility factors and why asthma patients are not over-represented in those with COVID-19 complications.
has issue date	2020-07-29(xsd:dateTime)
bibo:doi	10.1101/2020.07.26.20162248
has license	medrxiv
sha1sum (hex)	e1370b9a76f057315177c0bf8820fc950b1fc794
schema:url	https://doi.org/10.1101/2020.07.26.20162248
resource representing a document's title	ACE2 Expression is elevated in Airway Epithelial Cells from aged and male donors but reduced in asthma
resource representing a document's body	covid:e1370b9a76f057315177c0bf8820fc950b1fc794#body_text
is schema:about of	named entity 'DISEASE' named entity 'Furin' named entity 'disease' named entity 'ADAM' named entity 'Epithelial' named entity 'ACE2' named entity 'SARS-COV-2' named entity 'asthma' named entity 'Airway' named entity 'Epithelial Cells' named entity 'expression' named entity 'SARS-CoV-2' named entity 'SARS-CoV-2' named entity 'written consent' named entity 'diabetes' named entity 'pack-year' named entity 'asthma' named entity 'Formalin-fixed' named entity 'ADAM17' named entity 'epithelium' named entity 'inflammation' named entity 'asthma' named entity 'gene expression' named entity 'asthma' named entity 'epithelial cells' named entity 'ACE2' named entity 'SARS-CoV-2' named entity 'NL63' named entity 'receptor expression' named entity 'atopy' named entity 'Viral' named entity 'endobronchial' named entity 'asthma' named entity 'regression analyses' named entity 'COVID' named entity 'inflammation' named entity 'cardiovascular disease' named entity 'Epithelial' named entity 'biopsies' named entity 'coronavirus' named entity 'COPD' named entity 'upper respiratory tract infection' named entity 'COPD' named entity 'Furin' named entity 'OC43' named entity 'asthma' named entity 'Furin' named entity 'asthma' named entity 'gene expression' named entity 'asthma' named entity 'gene expression' named entity 'spike protein' named entity 'virus' named entity 'atopy' named entity 'ACE2' named entity 'virus' named entity 'sputum' named entity 'receptor' named entity 'lung' named entity 'TMPRSS2' named entity 'FEV1/FVC' named entity 'asthma' named entity 'MERS'

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