About: Ethnic and socioeconomic differences in SARS-CoV2 infection in the UK Biobank cohort study

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Ethnic and socioeconomic differences in SARS-CoV2 infection in the UK Biobank cohort study
Creator	Celis-Morales, Carlos Demou, Evangelia Dinesh, Bhautesh Frederick, ] Ho, K Mair, Frances Nicholl, Barbara Niedzwiedz, Claire O'donnell, Catherine Pell, Jill Sattar, Naveed Vittal Katikireddi, ] Welsh, Paul
Source	MedRxiv
abstract	Background Understanding of the role of ethnicity and socioeconomic position in the risk of developing SARS-CoV-2 infection is limited. We investigated this in the UK Biobank study. Methods The UK Biobank study recruited 40-70 year olds in 2006-2010 from the general population, collecting information about self-defined ethnicity and socioeconomic variables (including Townsend deprivation index and educational attainment). SARS-CoV-2 test results from Public Health England were linked to baseline UK Biobank data. Poisson regression with robust standard errors was used to assess risk ratios (RRs) between the exposures and dichotomous variables for: being tested, having a positive test and testing positive in hospital. We also investigated whether ethnicity and socioeconomic position were associated with having a positive test amongst those tested. We adjusted for covariates including age, sex, social variables (including healthcare work and household size), behavioural risk factors and baseline health. Findings Among 428,225 participants, 1,474 had been tested and 669 had tested positive between 16 March and 13 April 2020. Black, south Asian and white Irish people were more likely to have confirmed infection (RR 4.01 (95%CI 2.92-5.12); RR 2.11 (95%CI 1.43-3.10); and RR 1.60 (95% CI 1.08-2.38) respectively) and were more likely to be hospitalised compared to White British. While they were more likely to be tested, they were also more likely to test positive. Adjustment for baseline health and behavioural risk factors led to little change, with only modest attenuation when accounting for socioeconomic variables. Area socioeconomic deprivation and having no qualifications were consistently associated with a higher risk of confirmed infection (RR 1.91 (95%CI 1.53-2.38); and RR 2.26 (95%CI 1.76-2.90) respectively). Interpretation Some minority ethnic groups have a higher risk of confirmed SARS-CoV-2 infection in the UK Biobank study which was not accounted for by differences in socioeconomic conditions, measured baseline health or behavioural risk factors. An urgent response to addressing these elevated risks is required. Funding Medical Research Council, Chief Scientist Office.
has issue date	2020-04-27(xsd:dateTime)
bibo:doi	10.1101/2020.04.22.20075663
has license	medrxiv
sha1sum (hex)	e14bf19943aca8e337fec3d81490b6bb93a08866
schema:url	https://doi.org/10.1101/2020.04.22.20075663
resource representing a document's title	Ethnic and socioeconomic differences in SARS-CoV2 infection in the UK Biobank cohort study
resource representing a document's body	covid:e14bf19943aca8e337fec3d81490b6bb93a08866#body_text
is schema:about of	named entity 'investigated' named entity 'Ethnic' named entity 'SARS-COV-2 INFECTION' named entity 'STUDY' named entity 'study' named entity 'SARS-CoV-2' named entity 'cohort study' named entity 'UK Biobank' named entity 'socioeconomic' named entity 'higher risk' named entity 'social groups' named entity 'social groups' named entity 'risk factors' named entity 'socioeconomic groups' named entity 'SARS-CoV-2' named entity 'Intensive Care' named entity 'positive test' named entity 'in-patient' named entity 'risk factors' named entity '5.52' named entity 'positive or negative' named entity 'in-patient' named entity 'pandemics' named entity 'cohort study' named entity '1.08' named entity 'Statistical analysis' named entity 'Ascertainment bias' named entity 'US Centers for Disease Control and Prevention' named entity 'socioeconomic differences' named entity 'social groups' named entity 'UK Biobank' named entity 'UK Biobank' named entity 'PHE' named entity 'assessment centre' named entity 'socioeconomic groups' named entity 'Ireland' named entity 'Audit' named entity 'infection' named entity 'White Irish' named entity 'UK Biobank' named entity 'higher risk' named entity 'SARS-CoV-2' named entity 'infection' named entity 'sample size' named entity 'COVID-19 disease' named entity 'ethnicity' named entity 'healthcare worker' named entity 'medRxiv' named entity 'positive test' named entity 'social groups' named entity 'infection' named entity 'SARS-CoV-2' named entity 'disability' named entity 'medRxiv' named entity 'COVID-19' named entity 'infection' named entity 'ethnic groups' named entity 'social groups' named entity 'Ethnicity' named entity 'medRxiv' named entity 'rent free' named entity 'infection' named entity 'CC-BY 4.0 International license' named entity 'health services' named entity 'care home' named entity 'prognosis' named entity 'relative risks' named entity 'virus' named entity 'health service' named entity 'BMI' named entity 'empirical data' named entity 'ethnicity' named entity 'health service'

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