About: Airway protease/antiprotease imbalance in atopic asthmatics contributes to increased Influenza A virus cleavage and replication

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About: Airway protease/antiprotease imbalance in atopic asthmatics contributes to increased Influenza A virus cleavage and replication Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Airway protease/antiprotease imbalance in atopic asthmatics contributes to increased Influenza A virus cleavage and replication
Creator	Jaspers, Ilona Hernandez, Michelle Kesic, Matthew
Source	Medline; PMC
abstract	Asthmatics are more susceptible to influenza infections, yet mechanisms mediating this enhanced susceptibility are unknown. Influenza virus hemagglutinin (HA) protein binds to sialic acid residues on the host cells. HA requires cleavage to allow fusion of the viral HA with host cell membrane, which is mediated by host trypsin-like serine protease. We show data here demonstrating that the protease:antiprotease ratio is increased in the nasal mucosa of asthmatics and that these changes were associated with increased proteolytic activation of influenza. These data suggest that disruption of the protease balance in asthmatics enhances activation and infection of influenza virus.
has issue date	2012-09-19(xsd:dateTime)
bibo:doi	10.1186/1465-9921-13-82
bibo:pmid	22992220
has license	cc-by
sha1sum (hex)	e1a771476018079cd6dcb063ae78e04ca349ba08
schema:url	https://doi.org/10.1186/1465-9921-13-82
resource representing a document's title	Airway protease/antiprotease imbalance in atopic asthmatics contributes to increased Influenza A virus cleavage and replication
has PubMed Central identifier	PMC3489803
has PubMed identifier	22992220
schema:publication	Respir Res
resource representing a document's body	covid:e1a771476018079cd6dcb063ae78e04ca349ba08#body_text
is schema:about of	named entity 'HERE' named entity 'INFLUENZA' named entity 'PROTEOLYTIC ACTIVATION' named entity 'INFECTION' named entity 'NASAL MUCOSA' named entity 'ASTHMATICS' named entity 'SUSCEPTIBLE' named entity 'PROTEIN ' named entity 'DATA' named entity 'RATIO' named entity 'protease' named entity 'proteolytic' named entity 'nasal mucosa' named entity 'residues' named entity 'PROTEASE' named entity 'HOST CELL MEMBRANE' named entity 'THESE' named entity 'PROTEASE' named entity 'TRYPSIN-LIKE SERINE PROTEASE' named entity 'UNKNOWN' named entity 'DISRUPTION' named entity 'HOST' named entity 'INCREASED' named entity 'BINDS' named entity 'INFLUENZA VIRUS' named entity 'INCREASED' named entity 'CLEAVAGE' named entity 'ASTHMATICS' named entity 'INFLUENZA A VIRUS' named entity 'ATOPIC' named entity 'REPLICATION' named entity 'IMBALANCE' named entity 'SUSCEPTIBILITY' named entity 'CHANGES' named entity 'HOST CELLS' named entity 'SUGGEST' named entity 'ACTIVATION' named entity 'INFECTIONS' named entity 'AIRWAY' named entity 'FUSION' named entity 'BALANCE' named entity 'HEMAGGLUTININ' named entity 'ALLOW' named entity 'SIALIC ACID' named entity 'MECHANISMS' named entity 'CLEAVAGE' named entity 'MEDIATING' named entity 'ASSOCIATED WITH' named entity 'ENHANCED' named entity 'VIRAL' named entity 'MEDIATED' named entity 'host' named entity 'These' named entity 'acid' named entity 'data' named entity 'activation' named entity 'Influenza virus' named entity 'mediating' named entity 'replication' named entity 'antiprotease' named entity 'serine protease' named entity 'influenza' named entity 'asthmatics' named entity 'Influenza virus' named entity 'Asthmatics' named entity 'nasal mucosa' named entity 'cell membrane' named entity 'antiprotease' named entity 'atopic' named entity 'influenza' named entity 'TMPRSS2' named entity 'influenza' named entity 'host cell' named entity 'secretion' named entity 'proteolytic activity' named entity 'protease' named entity 'virions' named entity 'protein' named entity 'assay'

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