About: Single-cell atlas of a non-human primate reveals new pathogenic mechanisms of COVID-19

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About: Single-cell atlas of a non-human primate reveals new pathogenic mechanisms of COVID-19 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Single-cell atlas of a non-human primate reveals new pathogenic mechanisms of COVID-19
Creator	Wang, Jian Liu, Yang Yu, Hao Wu, Tao Wang, Zhifeng Liu, Chuanyu Ward, Carl Yang, Huanming Liu, Shiping Yuan, Yue Tang, Tingting Wong, Chi Xu, Xun Zhu, Shida Cheng, Mengnan Esteban, Miguel Han, Lei Hou, Yong Huang, Yunting Ji, Weizhi Lai, Yiwei Lei, Ying Liu, Longqi Liu, Ya Lu, Haorong Maxwell, Patrick Pan, Taotao Shi, Quan Sun, Haixi Tan, Tao Volpe, Giacomo Wang, Chunqing Watson, James Wei, Xiaoyu Wu, Liang Xu, Jiangshan Xu, Liqin Yu, Yeya Zhuang, Zhenkun
source	BioRxiv
abstract	Stopping COVID-19 is a priority worldwide. Understanding which cell types are targeted by SARS-CoV-2 virus, whether interspecies differences exist, and how variations in cell state influence viral entry is fundamental for accelerating therapeutic and preventative approaches. In this endeavor, we profiled the transcriptome of nine tissues from a Macaca fascicularis monkey at single-cell resolution. The distribution of SARS-CoV-2 facilitators, ACE2 and TMRPSS2, in different cell subtypes showed substantial heterogeneity across lung, kidney, and liver. Through co-expression analysis, we identified immunomodulatory proteins such as IDO2 and ANPEP as potential SARS-CoV-2 targets responsible for immune cell exhaustion. Furthermore, single-cell chromatin accessibility analysis of the kidney unveiled a plausible link between IL6-mediated innate immune responses aiming to protect tissue and enhanced ACE2 expression that could promote viral entry. Our work constitutes a unique resource for understanding the physiology and pathophysiology of two phylogenetically close species, which might guide in the development of therapeutic approaches in humans. Bullet points We generated a single-cell transcriptome atlas of 9 monkey tissues to study COVID-19. ACE2+TMPRSS2+ epithelial cells of lung, kidney and liver are targets for SARS-CoV-2. ACE2 correlation analysis shows IDO2 and ANPEP as potential therapeutic opportunities. We unveil a link between IL6, STAT transcription factors and boosted SARS-CoV-2 entry.
has issue date	2020-04-23(xsd:dateTime)
bibo:doi	10.1101/2020.04.10.022103
has license	biorxiv
sha1sum (hex)	e1e6416bb022439e5f15b3c20efc2ca444886247
schema:url	https://doi.org/10.1101/2020.04.10.022103
resource representing a document's title	Single-cell atlas of a non-human primate reveals new pathogenic mechanisms of COVID-19
schema:publication	bioRxiv
resource representing a document's body	covid:e1e6416bb022439e5f15b3c20efc2ca444886247#body_text
is schema:about of	named entity 'endothelial cells' named entity 'ACE2' named entity 'kidney' named entity 'proximal tubule' named entity 'SARS-CoV-2' named entity 'liver' named entity 'ACE2' named entity 'receptor' named entity 'liver' named entity 'proximal tubule' named entity 'liver' named entity 'hepatocytes' named entity 'toxic material' named entity 'lung' named entity 'ACE2' named entity 'ACE2' named entity 'infection' named entity 'non-human primate' named entity 'kidney' named entity 'distal convoluted tubule' named entity 'proximal tubule' named entity 'liver' named entity 'single-cell' named entity 'respiratory tract' named entity 'ACE2' named entity 'single-cell' named entity 'Indoleamine 2,3-dioxygenase' named entity 'COVID-19' named entity 'therapeutic targets' named entity 'cholangiocytes' named entity 'TMPRSS2' named entity 'ANPEP' named entity 'cholangiocytes' named entity 'correlation' named entity 'ACE2' named entity 'ACE2' named entity 'lung' named entity 'gene' named entity 'organ' named entity 'cholangiocytes' named entity 'SARS-CoV-2' named entity 'cynomolgus monkey' named entity 'kidney' named entity 'ACE2' named entity 'loss of taste' named entity 'COVID-19'

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