About: Camphor-based symmetric diimines as inhibitors of influenza virus reproduction

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Camphor-based symmetric diimines as inhibitors of influenza virus reproduction Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Camphor-based symmetric diimines as inhibitors of influenza virus reproduction
Creator	Zarubaev, Vladimir Anfimov, Pavel Kiselev, Oleg Korchagina, Dina Salakhutdinov, Nariman Sokolova, Anastasiya Tretiak, Tatiana Yarovaya, Olga
Source	Elsevier; Medline; PMC
abstract	Abstract Influenza is a continuing world-wide public health problem that causes significant morbidity and mortality during seasonal epidemics and sporadic pandemics. The purpose of the study was synthesis and investigation of antiviral activity of camphor-based symmetric diimines and diamines. A set of C2-symmetric nitrogen-containing camphor derivatives have been synthesized. The antiviral activity of these compounds was studied against rimantadine- and amantadine-resistant influenza virus A/California/7/09 (H1N1)pdm09 in MDCK cells. The highest efficacy in virus inhibiting was shown for compounds 2a–e with cage moieties bound by aliphatic linkers. The therapeutic index (selectivity index) for 2b exceeded that for reference compounds amantadine, deitiforin and rimantadine almost 10-fold. As shown by structure–activity analysis, the length of the linker has a dramatic effect on the toxicity of compounds. Compound 2e with –C12H24– linker exhibited the lowest toxicity (CTD50 =2216μM). Derivatives of camphor, therefore, can be considered as prospective antiinfluenza compounds active against influenza viruses resistant to adamantane-based drugs.
has issue date	2014-04-01(xsd:dateTime)
bibo:doi	10.1016/j.bmc.2014.02.038
bibo:pmid	24631360
has license	els-covid
sha1sum (hex)	e228678227264ff058fb50e363c08c9d4194fe8a
schema:url	https://doi.org/10.1016/j.bmc.2014.02.038
resource representing a document's title	Camphor-based symmetric diimines as inhibitors of influenza virus reproduction
has PubMed Central identifier	PMC7126937
has PubMed identifier	24631360
schema:publication	Bioorganic & Medicinal Chemistry
resource representing a document's body	covid:e228678227264ff058fb50e363c08c9d4194fe8a#body_text
is schema:about of	named entity 'WIDE' named entity 'HIGHEST' named entity 'ACTIVITY ANALYSIS' named entity 'IS A' named entity 'INHIBITING' named entity 'SYMMETRIC' named entity 'WORLD' named entity 'DIAMINES' named entity 'BASED' named entity 'pandemics' covid:arg/e228678227264ff058fb50e363c08c9d4194fe8a named entity 'STUDY' named entity 'VIRUS' named entity 'DEITIFORIN' named entity '2F7' named entity 'FOLD' named entity 'BASED' named entity 'REPRODUCTION' named entity 'CAUSES' named entity 'RESISTANT' named entity 'ALIPHATIC' named entity 'HEALTH PROBLEM' named entity 'SET' named entity 'EPIDEMICS' named entity 'PANDEMICS' named entity 'SIGNIFICANT' named entity 'CAMPHOR' named entity 'MDCK CELLS' named entity 'CONTAINING' named entity 'PURPOSE' named entity 'TOXICITY' named entity 'NITROGEN' named entity 'MORBIDITY AND MORTALITY' named entity 'CONTINUING' named entity 'CAGE' named entity 'INDEX' named entity 'THERAPEUTIC INDEX' named entity 'HAVE' named entity 'BOUND' named entity 'INFLUENZA' named entity 'SEASONAL' named entity 'EFFICACY' named entity 'STRUCTURE' named entity 'AS INHIBITORS' named entity 'INFLUENZA VIRUS' named entity 'SYMMETRIC' named entity 'PUBLIC HEALTH' named entity 'INVESTIGATION' named entity 'THESE' named entity 'ANTIVIRAL ACTIVITY' named entity 'LENGTH' named entity 'INFLUENZA VIRUS A' named entity 'LINKER' named entity 'RIMANTADINE' named entity 'REFERENCE' named entity 'EFFECT' named entity 'SPORADIC' named entity 'ALMOST' named entity 'AMANTADINE' named entity 'CAMPHOR' named entity 'SYNTHESIS' named entity 'rimantadine' named entity 'study' named entity 'activity' named entity 'C2-symmetric' named entity 'California' named entity 'efficacy' named entity 'derivatives' named entity 'set' named entity 'The' named entity 'morbidity' named entity 'antiviral activity' named entity 'rimantadine' named entity 'toxicity'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software