About: The association between markers of liver injury and clinical outcomes in patients with COVID‐19 in Wuhan

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About: The association between markers of liver injury and clinical outcomes in patients with COVID‐19 in Wuhan Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The association between markers of liver injury and clinical outcomes in patients with COVID‐19 in Wuhan
Creator	Zhang, Jun Li, Hong Chen, \| Chen, Shanshan Dai, Yining Ge, Minghua Huang, Haijun Shao, Lina Tu, Yuexing Wang, Jiafeng Wang, Mingshan Wu Jia, \| Yan, Rong Zhou, Xian-Long
Source	Medline; PMC
abstract	BACKGROUND: The outbreak of coronavirus disease 2019 (COVID‐19) is a critical challenge for public health. The effect of COVID‐19 on liver injury has not been fully presented. AIMS: To evaluate the dynamic changes in liver function and the relationship between liver function damage and prognosis in patients with COVID‐19. METHODS: Retrospective analysis of clinical data of 675 patients with COVID‐19 in Zhongnan Hospital of Wuhan University from January 3 to March 8, 2020. Patients were classified as normal, abnormal liver function and liver injury. RESULTS: Of 675 patients, 253 (37.5%) had abnormal liver function during hospitalisation, and 52 (7.7%) had liver injury. The dynamic changes of ALT and AST levels were more significant in patients with liver injury and in those who died. AST >3‐fold ULN had the highest risk of death and mechanical ventilation. Compared to patients with normal AST levels, mortality and risk of mechanical ventilation significantly increased 19.27‐fold (95% confidence interval [CI], 4.89‐75.97; P < 0.0001) and 116.72‐fold (95% CI, 31.58‐431.46; P < 0.0001), respectively, in patients with AST above 3‐fold ULN. Increased leucocytes, decreased lymphocytes and female sex were independently associated with liver injury. CONCLUSIONS: The dynamic changes in liver function may have a significant correlation with the severity and prognosis of COVID‐19. Increased index of liver injury was closely related to mortality and need for mechanical ventilation. Therefore, these indicators should be closely monitored during hospitalisation.
has issue date	2020-07-22(xsd:dateTime)
bibo:doi	10.1111/apt.15962
bibo:pmid	32697870
has license	no-cc
sha1sum (hex)	e27551c49124276cbf4758cd2391222c9d35312d
schema:url	https://doi.org/10.1111/apt.15962
resource representing a document's title	The association between markers of liver injury and clinical outcomes in patients with COVID‐19 in Wuhan
has PubMed Central identifier	PMC7404742
has PubMed identifier	32697870
schema:publication	Aliment Pharmacol Ther
resource representing a document's body	covid:e27551c49124276cbf4758cd2391222c9d35312d#body_text
is schema:about of	named entity 'abnormal' named entity 'injury' named entity 'NORMAL' named entity 'COVID' named entity 'clinical outcomes' named entity 'clinical characteristics' named entity 'liver function' named entity 'coronavirus' named entity 'liver function' named entity 'liver injury' named entity 'fever' named entity 'scatterplot smoothing' named entity 'chronic obstructive pulmonary disease' named entity 'medical records' named entity 'aspartate aminotransferase' named entity 'liver injury' named entity 'mechanical ventilation' named entity 'chronic obstructive pulmonary disease' named entity 'chronic liver disease' named entity 'COVID' named entity 'mm Hg' named entity 'COVID' named entity 'clinical characteristics' named entity 'COVID' named entity 'liver' named entity 'AST' named entity 'liver injury' named entity 'COVID' named entity 'liver function' named entity 'hepatocytes' named entity 'liver' named entity 'liver injury' named entity 'liver injury' named entity 'clinical characteristics' named entity 'prognosis' named entity 'liver injury' named entity 'COVID' named entity 'cohort study' named entity 'lymphocytes' named entity 'liver injury' named entity 'AST' named entity 'mechanical ventilation' named entity 'pathogen' named entity 'in-patients' named entity 'liver injury' named entity 'AST' named entity 'liver' named entity 'COVID' named entity 'liver injury' named entity 'liver injury' named entity 'severe acute respiratory syndrome coronavirus 2' named entity 'dyspnoea' named entity 'liver injury' named entity 'retrospective study' named entity 'liver function' named entity 'AST' named entity 'lymphopenia' named entity 'hypertension' named entity 'clinical outcomes' named entity 'liver injury' named entity 'public health emergency of international concern' named entity 'statistically significant' named entity 'COVID-19' named entity 'immune-mediated' named entity 'liver' named entity 'CDC' named entity 'causality' named entity 'TBIL'

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