About: Antiproliferative and apoptotic activity of glycyrrhizinic acid in MCF-7 human breast cancer cells and evaluation of its effect on cell cycle, cell migration and m-TOR/PI3K/Akt signalling pathway

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About: Antiproliferative and apoptotic activity of glycyrrhizinic acid in MCF-7 human breast cancer cells and evaluation of its effect on cell cycle, cell migration and m-TOR/PI3K/Akt signalling pathway Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Antiproliferative and apoptotic activity of glycyrrhizinic acid in MCF-7 human breast cancer cells and evaluation of its effect on cell cycle, cell migration and m-TOR/PI3K/Akt signalling pathway
Creator	Feng, Yun Zhang, Zhen Cao, Xiao-Zhong Li, Zhen-Yu
source	Medline; PMC
abstract	INTRODUCTION: Glycyrrhizinic acid is a natural product of pharmacological relevance and its anticancer activity against breast cancer cell lines has not been evaluated. Therefore the main purpose of the present study was to investigate the anticancer effects of glycyrrhizinic acid in MCF-7 human breast cancer cells. MATERIAL AND METHODS: The MTT assay was used to evaluate the anticancer effects while a clonogenic assay was used to study its effects on colony formation tendency. Flow cytometry was used to study the effects on cell cycle phase distribution and apoptosis. Western blot assay was used to study changes in protein expression of the m-TOR/PI3K/Akt pathway. RESULTS: The results indicated that glycyrrhizinic acid caused significant (p < 0.01). The growth inhibitory effects MCF-7 human breast cancer cells. The growth inhibitory effects of glycyrrhizinic acid exhibited concentration-dependent as well as time-dependent growth inhibitory trend. Different doses of glycyrrhizinic acid had a tendency to significantly (p < 0.01) inhibit the colony formation tendency of MCF-7 cells. As compared to the control group, glycyrrhizinic acid-treated cells showed a high percentage of apoptotic cells. Cells treated with a 10, 50 and 100 µM dose of glycyrrhizinic acid led to a 24.3%, 41.5% and 82.1% increase in the sub-G1 phase (apoptotic) cells. Glycyrrhizinic acid also led to significant (p < 0.01) inhibition of cell invasion along with downregulation of m-TOR/PI3K/Akt protein expression. CONCLUSIONS: Glycyrrhizinic acid inhibited MCF-7 human breast cancer cell growth and therefore may prove essential lead molecule in the treatment of breast cancer.
has issue date	2018-11-08(xsd:dateTime)
bibo:doi	10.5114/aoms.2018.79429
bibo:pmid	30697268
has license	cc-by-nc-sa
sha1sum (hex)	e27e8c74a021090c4f54ccfca13646232741638a
schema:url	https://doi.org/10.5114/aoms.2018.79429
resource representing a document's title	Antiproliferative and apoptotic activity of glycyrrhizinic acid in MCF-7 human breast cancer cells and evaluation of its effect on cell cycle, cell migration and m-TOR/PI3K/Akt signalling pathway
has PubMed Central identifier	PMC6348358
has PubMed identifier	30697268
schema:publication	Arch Med Sci
resource representing a document's body	covid:e27e8c74a021090c4f54ccfca13646232741638a#body_text
is schema:about of	named entity 'EFFECT' named entity 'MCF-7' named entity 'GLYCYRRHIZINIC ACID' named entity 'ANTIPROLIFERATIVE' named entity 'HUMAN BREAST CANCER CELLS' named entity 'CELL CYCLE' named entity 'EVALUATION' named entity 'ON CELL' named entity '2C CELL' named entity 'SIGNALLING PATHWAY' named entity 'TOR' named entity 'ACTIVITY' named entity 'CELL MIGRATION' named entity 'BASIC RESEARCH' named entity 'APOPTOTIC' named entity 'ITS' named entity 'acid' named entity 'TOR' named entity 'flow cytometry' named entity 'western blot' named entity 'cytotoxic effects' named entity 'anthocyanins' named entity 'Shanghai' named entity 'cell cycle arrest' named entity 'HPLC' named entity 'propidium iodide' named entity 'chemical reagents' named entity 'G2/M' named entity 'cell culture' named entity 'cell cycle' named entity 'viruses' named entity 'cell cycle analysis' named entity 'apoptosis' named entity 'phosphate' named entity 'glycyrrhizinic acid' named entity 'advanced stages' named entity 'Cell cycle arrest' named entity 'Glycyrrhizinic acid' named entity 'mitochondria' named entity 'MCF-7' named entity 'AKT' named entity 'apoptosis' named entity 'MCF-7' named entity 'glycyrrhizinic acid' named entity 'protein' named entity 'semi-synthetically' named entity 'TOR' named entity 'antiviral' named entity 'GAPDH' named entity 'PI3K/Akt signalling' named entity 'glycyrrhizinic acid' named entity 'apoptosis' named entity 'cytotoxic effects' named entity 'Annexin' named entity 'Western blot' named entity 'development of drugs' named entity 'glycyrrhizinic acid' named entity 'MCF-7' named entity 'protein expression' named entity 'anticancer activity' named entity 'medicinal plant' named entity 'Cell Signaling Technology' named entity 'MCF-7' named entity 'Millipore' named entity 'PI3K' named entity 'MCF-7' named entity '15,000' named entity 'cell cycle arrest' named entity 'glycyrrhizinic acid' named entity 'cancer cells' named entity 'insoluble' named entity 'Bio-Rad' named entity 'PBS' named entity 'drug discovery' named entity 'glycyrrhizinic acid' named entity 'Glycyrrhiza glabra' named entity 'Glycyrrhizinic acid' named entity 'terpenoids'

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