About: Epstein-Barr virus-induced gene 3 negatively regulates neuroinflammation and T cell activation following coronavirus-induced encephalomyelitis

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About: Epstein-Barr virus-induced gene 3 negatively regulates neuroinflammation and T cell activation following coronavirus-induced encephalomyelitis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Epstein-Barr virus-induced gene 3 negatively regulates neuroinflammation and T cell activation following coronavirus-induced encephalomyelitis
Creator	Tirotta, Emanuele Duncker, Patrick Gov, Lanny Klaus, Suzi Oak, Jean Lane, Thomas Tsukamoto, Michelle
topic	covid:e2c073e2f324b170d2786d8374690a11981c5e06#this
Source	Elsevier; Medline; PMC
abstract	Epstein-Barr virus-induced gene 3 (EBI3) associates with p28 and p35 to form the immunomodulatory cytokines IL-27 and IL-35, respectively. Infection of EBI3−/− mice with the neuroadapted JHM strain of mouse hepatitis virus (JHMV) resulted in increased mortality that was not associated with impaired ability to control viral replication but enhanced T cell and macrophage infiltration into the CNS. IFN-γ secretion from virus-specific CD4+ and CD8+ T cells isolated from infected EBI3−/− mice was augmented while IL-10 expression muted in comparison to infected WT mice. These data demonstrate a regulatory role for EBI3-associated cytokines in controlling host responses following CNS viral infection.
has issue date	2013-01-01(xsd:dateTime)
bibo:doi	10.1016/j.jneuroim.2012.10.005
bibo:pmid	23102608
has license	bronze-oa
sha1sum (hex)	e2c073e2f324b170d2786d8374690a11981c5e06
schema:url	https://doi.org/10.1016/j.jneuroim.2012.10.005
resource representing a document's title	Epstein-Barr virus-induced gene 3 negatively regulates neuroinflammation and T cell activation following coronavirus-induced encephalomyelitis
has PubMed Central identifier	PMC3534940
has PubMed identifier	23102608
schema:publication	Journal of Neuroimmunology
resource representing a document's body	covid:e2c073e2f324b170d2786d8374690a11981c5e06#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/e2c073e2f324b170d2786d8374690a11981c5e06
is schema:about of	named entity 'ENCEPHALOMYELITIS' named entity 'AUGMENTED' named entity 'ASSOCIATES' named entity 'EXPRESSION' named entity 'DATA' named entity 'TO FORM' named entity 'IL-35' named entity 'RESPONSES' named entity 'macrophage' named entity 'enhanced' named entity 'mice' named entity 'encephalomyelitis' named entity 'INDUCED' named entity 'P28' named entity 'CORONAVIRUS' named entity 'MACROPHAGE INFILTRATION' named entity 'CONTROLLING' named entity 'THESE' named entity 'ENHANCED' named entity 'T CELLS' named entity 'FOLLOWING' named entity 'MOUSE HEPATITIS VIRUS' named entity 'SPECIFIC' named entity 'VIRAL INFECTION' named entity 'CD4' named entity 'VIRUS' named entity 'TO CONTROL' named entity 'T CELL ACTIVATION' named entity 'NEUROINFLAMMATION' named entity 'SECRETION' named entity 'HOST' named entity 'IMMUNOMODULATORY' named entity 'IMPAIRED' named entity 'BUT' named entity 'P35' named entity 'VIRAL REPLICATION' named entity 'MUTED' named entity 'CNS' named entity 'EPSTEIN-BARR VIRUS-INDUCED GENE 3' named entity 'FOLLOWING' named entity 'EPSTEIN-BARR VIRUS-INDUCED GENE 3' named entity 'STRAIN' named entity 'IL-27' named entity 'ASSOCIATED' named entity 'COMPARISON' named entity 'IFN' named entity 'ASSOCIATED WITH' named entity 'INFECTED' named entity 'CD8' named entity 'INCREASED MORTALITY' named entity 'IL-10' named entity 'MICE' named entity 'REGULATORY ROLE' named entity 'T CELL' named entity 'ISOLATED' named entity 'INFECTION' named entity 'CYTOKINES' named entity 'EBI3' covid:arg/e2c073e2f324b170d2786d8374690a11981c5e06 named entity 'CNS' named entity 'viral infection' named entity 'secretion' named entity 'EBI3' named entity 'viral replication' named entity 'EBI3' named entity 'mouse hepatitis virus' named entity 'CD8+ T cells' named entity 'CNS' named entity 'IL-27' named entity 'CD4 +' named entity 'neuroinflammation' named entity 'IL-27' named entity 'CD8'

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