About: Antiviral Activity and Possible Mechanism of Action of Constituents Identified in Paeonia lactiflora Root toward Human Rhinoviruses

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About: Antiviral Activity and Possible Mechanism of Action of Constituents Identified in Paeonia lactiflora Root toward Human Rhinoviruses Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Antiviral Activity and Possible Mechanism of Action of Constituents Identified in Paeonia lactiflora Root toward Human Rhinoviruses
Creator	Ahn, Young Kwon, Min Ngan, Jang, Luong, Thi Myeong, Jin
Source	PMC
abstract	Human rhinoviruses (HRVs) are responsible for more than half of all cases of the common cold and cost billions of USD annually in medical visits and missed school and work. An assessment was made of the antiviral activities and mechanisms of action of paeonol (PA) and 1,2,3,4,6-penta-O-galloyl-β-D-glucopyranose (PGG) from Paeonia lactiflora root toward HRV-2 and HRV-4 in MRC5 cells using a tetrazolium method and real-time quantitative reverse transcription polymerase chain reaction and enzyme-linked immunosorbent assay. Results were compared with those of a reference control ribavirin. Based on 50% inhibitory concentration values, PGG was 13.4 and 18.0 times more active toward HRV-2 (17.89 μM) and HRV-4 (17.33 μM) in MRC5 cells, respectively, than ribavirin. The constituents had relatively high selective index values (3.3–>8.5). The 100 μg/mL PA and 20 μg/mL PGG did not interact with the HRV-4 particles. These constituents inhibited HRV-4 infection only when they were added during the virus inoculation (0 h), the adsorption period of HRVs, but not after 1 h or later. Moreover, the RNA replication levels of HRVs were remarkably reduced in the MRC5 cultures treated with these constituents. These findings suggest that PGG and PA may block or reduce the entry of the viruses into the cells to protect the cells from the virus destruction and abate virus replication, which may play an important role in interfering with expressions of rhinovirus receptors (intercellular adhesion molecule-1 and low-density lipoprotein receptor), inflammatory cytokines (interleukin (IL)-6, IL-8, tumor necrosis factor, interferon beta, and IL-1β), and Toll-like receptor, which resulted in diminishing symptoms induced by HRV. Global efforts to reduce the level of synthetic drugs justify further studies on P. lactiflora root-derived materials as potential anti-HRV products or lead molecules for the prevention or treatment of HRV.
has issue date	2015-04-10(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0121629
bibo:pmid	25860871
has license	cc-by
sha1sum (hex)	e2de7af2f055e3cf79556848d5b6aa2d27c4b97d
schema:url	https://doi.org/10.1371/journal.pone.0121629
resource representing a document's title	Antiviral Activity and Possible Mechanism of Action of Constituents Identified in Paeonia lactiflora Root toward Human Rhinoviruses
has PubMed Central identifier	PMC4393083
has PubMed identifier	25860871
schema:publication	PLoS One
resource representing a document's body	covid:e2de7af2f055e3cf79556848d5b6aa2d27c4b97d#body_text
is schema:about of	named entity 'PREVENTION' named entity '13.4' named entity 'METHOD' named entity 'ROOT' named entity 'ACTIVITIES' named entity 'INDEX' named entity 'HALF' named entity 'TO REDUCE' named entity 'JUSTIFY' named entity 'VALUES' named entity 'CONTROL' named entity 'TREATED WITH' named entity 'VIRUS REPLICATION' named entity 'STUDIES' named entity 'REDUCED' named entity 'INOCULATION' named entity 'INDUCED' named entity 'INFLAMMATORY' named entity 'ACTIVE' named entity '2C4' named entity 'DESTRUCTION' named entity 'RHINOVIRUSES' named entity '50%' named entity 'TIMES' named entity 'TETRAZOLIUM' named entity 'CASES' named entity 'INTERFERING' named entity 'PGG' named entity 'RESULTS' named entity 'COMMON COLD' named entity 'MRC5' named entity 'ribavirin' named entity 'assessment' named entity 'control' named entity 'viruses' named entity 'Activity' covid:arg/e2de7af2f055e3cf79556848d5b6aa2d27c4b97d named entity 'POSSIBLE' named entity 'RECEPTORS' named entity 'HRV-2' named entity 'ACTION' named entity 'CYTOKINES' named entity 'CULTURES' named entity '2C6' named entity 'FINDINGS' named entity 'SYNTHETIC DRUGS' named entity 'RIBAVIRIN' named entity 'MATERIALS' named entity 'RESPONSIBLE' named entity 'LEVELS' named entity 'LATER' named entity 'PARTICLES' named entity 'SYMPTOMS' named entity 'MEDICAL' named entity '283' named entity 'HRV' named entity 'REDUCE' named entity 'ANNUALLY' named entity 'VIRUS' named entity 'PLAY' named entity '1 H' named entity 'D-GLUCOPYRANOSE' named entity 'PAEONIA LACTIFLORA' named entity '100' named entity 'ROLE' named entity 'ADHESION MOLECULE' named entity 'ANTIVIRAL' named entity 'INHIBITED' named entity 'QUANTITATIVE REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION' named entity 'IMPORTANT' named entity 'RHINOVIRUSES' named entity 'MECHANISM OF ACTION' named entity 'ANTIVIRAL ACTIVITY' named entity 'HUMAN' named entity 'PAEONIA LACTIFLORA' named entity 'CONSTITUENTS'

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