About: SARS-CoV-2 Virologic and Immunologic Correlates in Patients with Olfactory and Taste Disorders

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	SARS-CoV-2 Virologic and Immunologic Correlates in Patients with Olfactory and Taste Disorders
Creator	Baldanti, Fausto Sarasini, Antonella Bruno, Raffaele Benazzo, Marco Bonetti, Alice Calastri, Anna Cassaniti, Irene Maiorano, Eugenia Novazzi, Federica
source	Medline; PMC
abstract	The main object of the study was to investigate the SARS-CoV-2 molecular and serological pattern in patients with mild symptoms including anosmia and ageusia. A cohort of 69 patients with olfactory and taste disorders (OTDs) were enrolled and prospectively monitored. Serological and molecular assays for the characterization of SARS-CoV-2 IgG and SARS-CoV-2 RNA, respectively, were performed at the time of enrolment and after 7 and 14 days. Patients were stratified according to the symptoms’ onset. A total of 52 patients (75.4%) were diagnosed as COVID-19 positive being SARS-CoV-2 RNA and/or SARS-CoV-2 IgG positive. The remaining 17 (24.6%) were negative for COVID-19 and excluded from the analysis. We reported that only 34 out of 52 patients (65.4%) were positive for SARS-CoV-2 RNA. Moreover, the median time from onset of symptoms and enrolment was significantly higher in those patients with negative SARS-CoV-2 RNA in nasal swabs, suggesting that symptoms might last longer than SARS-CoV-2 replication. The great majority of patients (80%) developed SARS-CoV-2 IgG at three weeks after symptoms’ onset while the detectability of SARS-CoV-2 RNA dramatically decreased over time, suggesting the crucial role of combination of molecular and serological assays for the diagnosis of COVID-19 in those patients reporting mild symptoms.
has issue date	2020-07-15(xsd:dateTime)
bibo:doi	10.3390/microorganisms8071052
bibo:pmid	32679910
has license	cc-by
sha1sum (hex)	e2e4b4378df64a1da24943598d75ddf511a54c0e
schema:url	https://doi.org/10.3390/microorganisms8071052
resource representing a document's title	SARS-CoV-2 Virologic and Immunologic Correlates in Patients with Olfactory and Taste Disorders
has PubMed Central identifier	PMC7409064
has PubMed identifier	32679910
schema:publication	Microorganisms
resource representing a document's body	covid:e2e4b4378df64a1da24943598d75ddf511a54c0e#body_text
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