About: Vacuolar neuronal degeneration in the ventral horns of SCID mice in naturally occurring Theiler's encephalomyelitis

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About: Vacuolar neuronal degeneration in the ventral horns of SCID mice in naturally occurring Theiler's encephalomyelitis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Vacuolar neuronal degeneration in the ventral horns of SCID mice in naturally occurring Theiler's encephalomyelitis
Creator	Sanchez, Susan Rozengurt, Nora
source	Elsevier; Medline; PMC
abstract	Abstract During a spontaneous outbreak of Theiler's encephalomyelitis severe combined immunodeficient mice developed high morbidity and high mortality. Histological lesions were localized in the ventral horns of the spinal cord and brain stem. The salient features were the severe vacuolar degeneration of neurones and glial cells and the absence of inflammatory cellular infiltrates. The clinical and pathological features of this outbreak indicate that the SCID mouse would be a much improved model for studying the mechanism of poliovirus infection and of virus-induced demyelinating diseases.
has issue date	1992-11-30(xsd:dateTime)
bibo:doi	10.1016/0021-9975(92)90013-k
bibo:pmid	1291587
has license	els-covid
sha1sum (hex)	e2f9cab9b2f415d70f2114a47f7b0b277d071e40
schema:url	https://doi.org/10.1016/0021-9975%2892%2990013-k
resource representing a document's title	Vacuolar neuronal degeneration in the ventral horns of SCID mice in naturally occurring Theiler's encephalomyelitis
has PubMed Central identifier	PMC7173180
has PubMed identifier	1291587
schema:publication	Journal of Comparative Pathology
resource representing a document's body	covid:e2f9cab9b2f415d70f2114a47f7b0b277d071e40#body_text
is schema:about of	named entity 'poliovirus' named entity 'immunodeficient' named entity 'MUCH' named entity 'vacuolar' named entity 'mechanism' named entity 'cellular' named entity 'morbidity' named entity 'glial cells' named entity 'morbidity' named entity 'virus' named entity 'spinal cord' named entity 'SCID' named entity 'degeneration' named entity 'serological' named entity 'TMEV' named entity 'ventral horns' named entity 'alphavirus' named entity 'infection' named entity 'immune mechanisms' named entity 'paralysis' named entity 'multiple sclerosis' named entity 'CNS' named entity 'flaccid paralysis' named entity 'blood samples' named entity 'oligodendrocytes' named entity 'vacuole' named entity 'gavage' named entity 'chromatolysis' named entity 'severe combined immunodeficiency' named entity 'pathognomonic' named entity 'infection' named entity '1, 2' named entity 'athymic' named entity 'infection' named entity 'clinical signs' named entity 'cytoplasm' named entity 'white matter' named entity 'motor neurones' named entity 'infection' named entity 'inclusion bodies' named entity 'antibodies' named entity 'Theiler's encephalomyelitis virus' named entity 'Kilham' named entity 'reovirus' named entity 'immunofluorescence' named entity 'gastrointestinal' named entity 'spinal cord' named entity 'phosphate' named entity 'TMEV' named entity 'glial cells' named entity 'immunocompetent' named entity 'intestine' named entity 'SCID mice' named entity 'motor neurones' named entity 'MHV' named entity 'brain stem' named entity 'cytoplasm' named entity 'inoculation' named entity 'nude mice' named entity 'bone marrow' named entity 'brain stem' named entity 'Viral' named entity 'BALB/c' named entity 'TMEV' named entity 'nuclei' named entity 'mice' named entity 'paralysis' named entity 'glial cell' named entity 'mice' named entity 'mice' named entity 'demyelinating diseases' named entity 'paraffin wax' named entity 'SCID mice' named entity 'vacuolar' named entity 'health screening' named entity 'TMEV' named entity 'pyknotic' named entity 'nucleus' named entity 'serological tests' named entity 'infection'

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