About: Quantitative phosphoproteome on the silkworm (Bombyx mori) cells infected with baculovirus

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About: Quantitative phosphoproteome on the silkworm (Bombyx mori) cells infected with baculovirus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Quantitative phosphoproteome on the silkworm (Bombyx mori) cells infected with baculovirus
Creator	Quan, Yanping Hu, Dongbing Shobahah, Jauharotus Wei, Ming Xue, Shengjie Yu, Wei Zhao, Cui
Source	Medline; PMC
abstract	BACKGROUND: Bombyx mori has become an important model organism for many fundamental studies. Bombyx mori nucleopolyhedrovirus (BmNPV) is a significant pathogen to Bombyx mori, yet also an efficient vector for recombinant protein production. A previous study indicated that acetylation plays many vital roles in several cellular processes of Bombyx mori while global phosphorylation pattern upon BmNPV infection remains elusive. METHOD: Employing tandem mass tag (TMT) labeling and phosphorylation affinity enrichment followed by high-resolution LC-MS/MS analysis and intensive bioinformatics analysis, the quantitative phosphoproteome in Bombyx mori cells infected by BmNPV at 24 hpi with an MOI of 10 was extensively examined. RESULTS: Totally, 6480 phosphorylation sites in 2112 protein groups were identified, among which 4764 sites in 1717 proteins were quantified. Among the quantified proteins, 81 up-regulated and 25 down-regulated sites were identified with significant criteria (the quantitative ratio above 1.3 was considered as up-regulation and below 0.77 was considered as down-regulation) and with significant p-value (p < 0.05). Some proteins of BmNPV were also hyperphosphorylated during infection, such as P6.9, 39 K, LEF-6, Ac58-like protein, Ac82-like protein and BRO-D. CONCLUSION: The phosphorylated proteins were primary involved in several specific functions, out of which, we focused on the binding activity, protein synthesis, viral replication and apoptosis through kinase activity.
has issue date	2017-06-19(xsd:dateTime)
bibo:doi	10.1186/s12985-017-0783-8
bibo:pmid	28629377
has license	cc-by
sha1sum (hex)	e332700e155cc5fdda4cb03b94d23df42647911b
schema:url	https://doi.org/10.1186/s12985-017-0783-8
resource representing a document's title	Quantitative phosphoproteome on the silkworm (Bombyx mori) cells infected with baculovirus
has PubMed Central identifier	PMC5477107
has PubMed identifier	28629377
schema:publication	Virol J
resource representing a document's body	covid:e332700e155cc5fdda4cb03b94d23df42647911b#body_text
is schema:about of	named entity 'studies' named entity 'baculovirus' named entity 'INDICATED' named entity 'BACKGROUND' named entity 'INFECTION' named entity 'PATHOGEN' named entity 'PHOSPHORYLATION' named entity 'GLOBAL' named entity 'IS A' named entity 'INFECTED' named entity 'CELLULAR PROCESSES' named entity 'PLAYS' named entity 'ROLES' named entity 'STUDIES' named entity 'VITAL' named entity 'EFFICIENT' named entity 'IMPORTANT' named entity 'ACETYLATION' named entity 'PATTERN' named entity 'SIGNIFICANT' named entity 'SILKWORM' named entity 'QUANTITATIVE' named entity 'MORI' named entity 'PHOSPHOPROTEOME' named entity 'VECTOR' named entity 'STUDY' named entity 'BOMBYX MORI' named entity 'PREVIOUS' named entity 'ORGANISM' named entity 'CELLS' named entity 'BACULOVIRUS' named entity 'MODEL' named entity 'RECOMBINANT PROTEIN PRODUCTION' named entity 'BMNPV' named entity 'BOMBYX MORI NUCLEOPOLYHEDROVIRUS' named entity 'cellular processes' named entity 'up-regulation' named entity 'motility' named entity 'peptide' named entity 'protein production' named entity 'peptide' named entity 'KEGG' named entity 'metabolic' named entity 'phosphorylation' named entity 'host cells' named entity 'NH 4' named entity 'Biotechnology' named entity 'biological thermodynamics' named entity 'virus' named entity 'vector' named entity 'Bombyx mori' named entity 'model organism' named entity 'acetylation' named entity 'Bombyx mori' named entity 'baculovirus' named entity 'up-regulated' named entity 'cytoskeletal protein' named entity 'm/z' named entity 'Gene Ontology' named entity 'actin' named entity 'protein' named entity 'metabolic processes' named entity 'down-regulated' named entity 'phosphorylation' named entity 'RNA polymerase II' named entity 'enzyme' named entity 'silkworm' named entity 'Apoptosis' named entity 'nucleopolyhedrovirus' named entity 'peptides' named entity 'vacuum' named entity 'China' named entity 'Orbitrap' named entity 'protein' named entity 'acetylated'

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