About: Epidemiology and Immediate Indirect Effects of Respiratory Viruses in Lung Transplant Recipients: A 5‐Year Prospective Study

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Epidemiology and Immediate Indirect Effects of Respiratory Viruses in Lung Transplant Recipients: A 5‐Year Prospective Study
Creator	Hirsch, H L Opez-Medrano, F Org, Len, O Codina, G Peghin, M Aez, B Berastegui, C Cabral, E Gavald, J Gavald, Joan Rom An, A Sol E, A Sol E, J Zurbano, F
source	Medline; PMC
abstract	The epidemiology of respiratory viruses (RVs) in lung transplant recipients (LTRs) and the relationship of RVs to lung function, acute rejection (AR) and opportunistic infections in these patients are not well known. We performed a prospective cohort study (2009–2014) by collecting nasopharyngeal swabs (NPSs) from asymptomatic LTRs during seasonal changes and from LTRs with upper respiratory tract infectious disease (URTID), lower respiratory tract infectious disease (LRTID) and AR. NPSs were analyzed by multiplex polymerase chain reaction. Overall, 1094 NPSs were collected from 98 patients with a 23.6% positivity rate and mean follow‐up of 3.4 years (interquartile range 2.5–4.0 years). Approximately half of URTIDs (47 of 97, 48.5%) and tracheobronchitis cases (22 of 56, 39.3%) were caused by picornavirus, whereas pneumonia was caused mainly by paramyxovirus (four of nine, 44.4%) and influenza (two of nine, 22.2%). In LTRs with LRTID, lung function changed significantly at 1 mo (p = 0.03) and 3 mo (p = 0.04). In a nested case–control analysis, AR was associated with RVs (hazard ratio [HR] 6.54), Pseudomonas aeruginosa was associated with LRTID (HR 8.54), and cytomegalovirus (CMV) replication or disease was associated with URTID (HR 2.53) in the previous 3 mo. There was no association between RVs and Aspergillus spp. colonization or infection (HR 0.71). In conclusion, we documented a high incidence of RV infections in LTRs. LRTID produced significant lung function abnormalities. Associations were observed between AR and RVs, between P. aeruginosa colonization or infection and LRTID, and between CMV replication or disease and URTID.
has issue date	2016-10-14(xsd:dateTime)
bibo:doi	10.1111/ajt.14042
bibo:pmid	27615811
has license	no-cc
sha1sum (hex)	e35025865bbd696c5a5f4c65f46df234458dbd4a
schema:url	https://doi.org/10.1111/ajt.14042
resource representing a document's title	Epidemiology and Immediate Indirect Effects of Respiratory Viruses in Lung Transplant Recipients: A 5‐Year Prospective Study
has PubMed Central identifier	PMC7159570
has PubMed identifier	27615811
schema:publication	Am J Transplant
resource representing a document's body	covid:e35025865bbd696c5a5f4c65f46df234458dbd4a#body_text
is schema:about of	named entity 'Epidemiology' named entity 'WORK' named entity 'AUTHORS' named entity 'Viruses' named entity 'Prospective Study' named entity 'tracheobronchitis' named entity 'infection' named entity 'HR 2' named entity 'coronaviruses' named entity 'infection' named entity 'paramyxovirus' named entity 'Madrid' named entity 'fatigue' named entity 'health status' named entity 'viruses' named entity 'ACE' named entity 'asymptomatic' named entity 'asymptomatic patients' named entity 'asymptomatic infections' named entity 'asymptomatic' named entity 'CMV' named entity 'morbidity' named entity 'collection of clinical data' named entity 'respiratory tract infection' named entity 'Germany' named entity 'viruses' named entity 'asymptomatic' named entity 'infection' named entity 'immunosuppression' named entity 'rhinorrhea' named entity 'picornaviruses' named entity 'nested case-control study' named entity 'parainfluenza' named entity 'outpatient clinic' named entity 'FEV' named entity 'aspirates' named entity '95% CI' named entity 'Epidemiological data' named entity 'cough' named entity 'France' named entity 'upper respiratory tract' named entity 'lung function' named entity 'immunosuppression' named entity 'picornavirus' named entity 'clinical presentation' named entity 'viral infection' named entity 'cytopathic' named entity 'Basel University Hospital' named entity 'picornaviruses' named entity 'inflammatory response' named entity 'nucleic acids' named entity 'prophylaxis' named entity 'viruses' named entity 'Aspergillus' named entity 'incidence rates' named entity 'RVs' named entity 'animal models' named entity 'opportunistic infections' named entity 'enteroviruses' named entity 'Aspergillus' named entity 'rhinovirus' named entity 'lung transplant' named entity 'allograft' named entity 'nasopharynx' named entity 'lung function' named entity 'opportunistic infections' named entity 'asymptomatic'

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