About: Pulmonary complications in toxic epidermal necrolysis: a prospective clinical study

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Pulmonary complications in toxic epidermal necrolysis: a prospective clinical study
Creator	Mondor, Delclaux, -Feith -C Delclaux, C Fleury, • Fleury-Feith, J Gisselbrecht, M H6pital, Henri Lange, -E Lange, F Lebargy, E Lebargy, F Revuz -J, • Revuz, J Roujeau, J Roupie, E Roupie, • Wolkenstein, P Wolkenstein, •
Source	PMC
abstract	Objective: To evaluate the incidence, clinical features, and prognosis of pulmonary complications associated with toxic epidermal necrolysis Design: Prospective study. Setting: Dermatology intensive care unit in Mondor Hospital, France. Patients: 41 consecutive patients. Interventions: On admission, then daily, respiratory evaluation was based on clinical examination, chest X-ray, and arterial blood gas analysis. When clinical symptoms, X-ray abnormalities, or hypoxemia [partial pressure of oxygen (PO(2))<80 mm Hg] were present, fiberoptic bronchoscopy was performed. Results: 10 patients presented early manifestations: dyspnea (n=10), bronchial hypersecretion (n=7), marked hypoxemia (n=10) (PO(2)=59 ± 8 mmHg). Chest X-ray was normal (n = 8) or showed interstitial infiltrates (n=2). In these 10 patients, fiberoptic bronchoscopy demonstrated sloughing of bronchial epithelium in proximal airways. Delayed pulmonary complications occurred in 6 of these 10 patients from day 7 to day 15: pulmonary edema (n=2), atelectasis (n=1), bacterial pneumonitis (n=4). Mechanical ventilation was required in 9 patients. A fatal outcome occurred in 7 patients. Seven patients did not develop early pulmonary manifestations (PO(2) on admission 87 ± 6 mm Hg) but only delayed pulmonary symptoms related to atelectasis (n=1), pulmonary edema (n=4), and bacterial pneumonitis (n=3); bronchial epithelial detachment was not observed. None of them required mechanical ventilation and all recovered with appropriate therapy. Conclusions: “Specific” involvement of bronchial epithelium was noted in 27 % of cases and must be suspected when dyspnea, bronchial hypersecretion, normal chest X-ray, and marked hypoxemia are present during the early stages of toxic epidermal necrosis. Bronchial injury seems to indicate a poor prognosis, as mechanical ventilation was required for most of these patients and was associated with a high mortality.
has issue date	1997-01-01(xsd:dateTime)
bibo:doi	10.1007/s001340050492
bibo:pmid	9470079
has license	no-cc
sha1sum (hex)	e35fb7ff0b866234df56180305809e135303ba5d
schema:url	https://doi.org/10.1007/s001340050492
resource representing a document's title	Pulmonary complications in toxic epidermal necrolysis: a prospective clinical study
has PubMed Central identifier	PMC7095164
has PubMed identifier	9470079
schema:publication	Intensive Care Med
resource representing a document's body	covid:e35fb7ff0b866234df56180305809e135303ba5d#body_text
is schema:about of	named entity 'DESIGN' named entity 'FRANCE' named entity 'OBJECTIVE' named entity 'HOSPITAL' named entity 'Design' named entity 'Objective' named entity 'SJS' named entity 'antibiotic therapy' named entity 'toxicity' named entity 'sepsis' named entity 'acute respiratory failure' named entity 'Mechanical ventilation' named entity 'chest X-ray' named entity 'metaplasia' named entity 'Bronchial' named entity 'pneumonitis' named entity 'plasma cells' named entity 'gastrointestinal' named entity 'metaplasia' named entity 'prognosis' named entity 'pneumonitis' named entity 'biopsy' named entity 'mucocutaneous' named entity 'epithelial barrier' named entity 'mm Hg' named entity 'clinical characteristics' named entity 'biopsies' named entity 'pulmonary edema' named entity 'bronchoscopy' named entity 'oropharyngeal' named entity 'Stevens-Johnson syndrome' named entity 'Mechanical ventilation' named entity 'skin lesions' named entity 'chest X-ray' named entity 'epithelial' named entity 'pulmonary complications' named entity 'monocytes' named entity 'diagnostic procedure' named entity 'body surface area' named entity 'hypoxemia' named entity 'acute respiratory failure' named entity 'secretion' named entity 'epithelialization' named entity 'multiple organ failure' named entity 'BSA' named entity 'syncytia' named entity 'Intensive Care Unit' named entity 'fluid intake' named entity 'dermis' named entity 'basement membrane' named entity 'human immunodeficiency virus infection' named entity 'toxic epidermal necrolysis' named entity 'sputum' named entity 'sputum' named entity 'toxic epidermal necrolysis' named entity 'macrophages' named entity 'acute respiratory failure' named entity 'Blood cell count' named entity 'respiratory symptoms' named entity 'pulmonary complications' named entity 'Histological' named entity 'Hospital' named entity 'pulmonary complications' named entity 'prognosis'

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