About: Mitochondrial-targeted ubiquinone: A potential treatment for COVID-19

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Mitochondrial-targeted ubiquinone: A potential treatment for COVID-19
Creator	Gong, Jie Ouyang, Lichen
Source	Elsevier; Medline; PMC
abstract	Immune dysregulation characterized by T cell exhaustion and high level of inflammatory cytokines is associated with severe COVID-19. Figuring out the early event of immune dysregulation would provide a potential treatment for COVID-19. Recent evidence indicate that mitochondrial dysfunction participates in the development of COVID-19 and may be responsible for the dysregulated immune response. Mitochondrial-targeted ubiquinone (MitoQ), a mitochondrial-targeted antioxidant, shows beneficial effects on various diseases through improving mitochondrial dysfunction. We hypothesize that MitoQ could act as a potential treatment in COVID-19. MitoQ may alleviate cytokine storm and restore the function of exhausted T cells in COVID-19 patients through improving mitochondrial dysfunction. In this article, we provide evidence to support the use of MitoQ as a potential treatment or adjunct therapy in the context of COVID-19.
has issue date	2020-08-05(xsd:dateTime)
bibo:doi	10.1016/j.mehy.2020.110161
bibo:pmid	32795832
has license	no-cc
sha1sum (hex)	e366daa0cbd3a4108319eb7fa744474ad19f02c4
schema:url	https://doi.org/10.1016/j.mehy.2020.110161
resource representing a document's title	Mitochondrial-targeted ubiquinone: A potential treatment for COVID-19
has PubMed Central identifier	PMC7403158
has PubMed identifier	32795832
schema:publication	Med Hypotheses
resource representing a document's body	covid:e366daa0cbd3a4108319eb7fa744474ad19f02c4#body_text
is schema:about of	named entity 'event' named entity 'exhaustion' named entity 'ubiquinone' named entity 'ACT' named entity 'EFFECTS' named entity 'provide' named entity 'T cell' named entity 'ubiquinone' named entity 'infection' named entity 'COVID-19' named entity 'remdesivir' named entity 'IL-10' named entity 'inflammation' named entity 'gene expression' named entity 'double-blind' named entity 'quinone' named entity 'mitochondrial' named entity 'ROS' named entity 'mitochondrial dysfunction' named entity 'host cells' named entity 'elderly age' named entity 'COVID' named entity 'PD-1' named entity 'ROS' named entity 'cardiovascular disease' named entity 'high levels' named entity 'ROS' named entity 'lymphocyte' named entity 'gene' named entity 'HCV' named entity 'SARS-CoV-2' named entity 'MitoQ' named entity 'cytokines' named entity 'type 2 diabetes' named entity 'antiviral drugs' named entity 'dietary supplement' named entity 'mitochondrial dysfunction' named entity 'cell line' named entity 'cardiovascular disease' named entity 'MitoQ' named entity 'antioxidants' named entity 'mitochondria' named entity 'MitoQ' named entity 'TIGIT' named entity 'restore' named entity 'adjunct therapy' named entity 'cytokine storm' named entity 'MitoQ' named entity 'COVID-19' named entity 'Mitochondrial' named entity 'Immune dysregulation' named entity 'mitochondrial' named entity 'mitochondrial dysfunction' named entity 'potential treatment' named entity 'COVID-19' named entity 'potential treatment' named entity 'Mitochondrial' named entity 'COVID' named entity 'respiration' named entity 'cytokine storm' named entity 'COVID' named entity 'Tim-3' named entity 'MitoQ' named entity 'acute lung injury' named entity 'MitoQ' named entity 'PD-1' named entity 'interferon' named entity 'IL-6' named entity 'China' named entity 'COS-1' named entity 'homeostasis' named entity 'mitochondria' named entity 'TNF-α' named entity 'mitochondrial' named entity 'ATP synthesis' named entity 'mitochondrial dysfunction' named entity 'comorbidities' named entity 'mitochondria' named entity 'administered orally' named entity 'NLRP3'

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