About: Characterisation of novel microRNAs in the Black flying fox (Pteropus alecto) by deep sequencing

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About: Characterisation of novel microRNAs in the Black flying fox (Pteropus alecto) by deep sequencing Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Characterisation of novel microRNAs in the Black flying fox (Pteropus alecto) by deep sequencing
Creator	Wang, Lin-Fa Zhou, Peng Cowled, Christopher Tachedjian, Mary Stewart, Cameron Marsh, Glenn Baker, Michelle Bean, Andrew Cottee, Pauline Friedländer, Marc Jenkins, Kristie Likic, Vladimir Tizard, Mark
source	PMC
abstract	BACKGROUND: Bats are a major source of new and emerging viral diseases. Despite the fact that bats carry and shed highly pathogenic viruses including Ebola, Nipah and SARS, they rarely display clinical symptoms of infection. Host factors influencing viral replication are poorly understood in bats and are likely to include both pre- and post-transcriptional regulatory mechanisms. MicroRNAs are a major mechanism of post-transcriptional gene regulation, however very little is known about them in bats. RESULTS: This study describes 399 microRNAs identified by deep sequencing of small RNA isolated from tissues of the Black flying fox, Pteropus alecto, a confirmed natural reservoir of the human pathogens Hendra virus and Australian bat lyssavirus. Of the microRNAs identified, more than 100 are unique amongst vertebrates, including a subset containing mutations in critical seed regions. Clusters of rapidly-evolving microRNAs were identified, as well as microRNAs predicted to target genes involved in antiviral immunity, the DNA damage response, apoptosis and autophagy. Closer inspection of the predicted targets for several highly supported novel miRNA candidates suggests putative roles in host-virus interaction. CONCLUSIONS: MicroRNAs are likely to play major roles in regulating virus-host interaction in bats, via dampening of inflammatory responses (limiting the effects of immunopathology), and directly limiting the extent of viral replication, either through restricting the availability of essential factors or by controlling apoptosis. Characterisation of the bat microRNA repertoire is an essential step towards understanding transcriptional regulation during viral infection, and will assist in the identification of mechanisms that enable bats to act as natural virus reservoirs. This in turn will facilitate the development of antiviral strategies for use in humans and other species. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/1471-2164-15-682) contains supplementary material, which is available to authorized users.
has issue date	2014-08-15(xsd:dateTime)
bibo:doi	10.1186/1471-2164-15-682
bibo:pmid	25128405
has license	cc-by
sha1sum (hex)	e375f5a2f337d86e69d22998aa8bda651ca68850
schema:url	https://doi.org/10.1186/1471-2164-15-682
resource representing a document's title	Characterisation of novel microRNAs in the Black flying fox (Pteropus alecto) by deep sequencing
has PubMed Central identifier	PMC4156645
has PubMed identifier	25128405
schema:publication	BMC Genomics
resource representing a document's body	covid:e375f5a2f337d86e69d22998aa8bda651ca68850#body_text
is schema:about of	named entity 'bats' named entity 'alecto' named entity 'FACT' named entity 'MICRORNAS' named entity 'DISPLAY' named entity 'influencing' named entity 'MicroRNAs' named entity 'symptoms' named entity 'carry' named entity 'mechanisms' named entity 'clinical symptoms' named entity 'miRNAs' named entity 'P. alecto' named entity 'seed' named entity 'gene' named entity 'P. alecto' named entity 'miR' named entity 'miRNAs' named entity 'miRBase' named entity 'experimental validation' named entity 'bat' named entity 'dorsal horn' named entity 'miRNAs' named entity 'miR' named entity 'miRNAs' named entity 'vertebrate' named entity 'miRNA' named entity 'positive selection' named entity 'zinc-finger protein' named entity '3' UTRs' named entity 'miRNA' named entity 'P. alecto' named entity 'protein' named entity 'mammals' named entity 'command line' named entity 'miRNAs' named entity 'sequence identity' named entity 'hit selection' named entity 'ligation' named entity 'miRNAs' named entity 'culling' named entity 'miRNA' named entity 'P. alecto' named entity 'false negatives' named entity 'bat' named entity 'molecular basis' named entity 'RFAM' named entity 'apoptosis' named entity 'high-throughput sequencing' named entity 'miRNA' named entity 'BLASTN' named entity 'cell cycle' named entity 'P. alecto' named entity 'virus' named entity 'DNA repair' named entity '11.0' named entity 'P. alecto' named entity 'gene regulation' named entity 'Homology' named entity 'Gene Ontology' named entity 'blue line' named entity 'liver' named entity 'transcription factor' named entity 'Bat' named entity 'miRNA' named entity '3' UTRs' named entity 'BLASTN' named entity 'miRNAs' named entity 'locus'

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