About: The influence of ABO blood groups on COVID-19 susceptibility and severity: a molecular hypothesis based on carbohydrate-carbohydrate interactions

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The influence of ABO blood groups on COVID-19 susceptibility and severity: a molecular hypothesis based on carbohydrate-carbohydrate interactions
Creator	Caetano Silva-Filho, José Caetano, José Farias De Melo, Cynthia Lima De Oliveira, Janaína
Source	Elsevier; PMC
abstract	The world is experiencing one of the most difficult moments in history with the COVID-19 pandemic, a disease caused by SARS-CoV-2, a new type of coronavirus. Virus infectivity is mediated by the binding of Spike transmembrane glycoprotein to specific protein receptors present on cell host surface. Spike is a homotrimer that emerges from the virion, each monomer containing two subunits named S1 and S2, which are related to cell recognition and membrane fusion, respectively. S1 is subdivided in domains S1A (or NTD) and S1B (or RBD), with experimental and in silico studies suggesting that the former binds to sialic acid-containing glycoproteins, such as CD147, whereas the latter binds to ACE2 receptor. Recent findings indicate that the ABO blood system modulates susceptibility and progression of infection, with type-A individuals being more susceptible to infection and/or manifestation of a severe condition. Seeking to understand the molecular mechanisms underlying this susceptibility, we carried out an extensive bibliographic survey on the subject. Based on this survey, we hypothesize that the correlation between the ABO blood system and susceptibility to SARS-CoV-2 infection can be presumably explained by the modulation of sialic acid-containing receptors distribution on host cell surface induced by ABO antigens through carbohydrate-carbohydrate interactions, which could maximize or minimize the virus Spike protein binding to the host cell. This model could explain previous sparse observations on the molecular mechanism of infection and can direct future research to better understand of COVID-19 pathophysiology.
has issue date	2020-08-02(xsd:dateTime)
bibo:doi	10.1016/j.mehy.2020.110155
has license	no-cc
sha1sum (hex)	e394bb1508e17cd28216b998cf2822f611ac4b45
schema:url	https://doi.org/10.1016/j.mehy.2020.110155
resource representing a document's title	The influence of ABO blood groups on COVID-19 susceptibility and severity: a molecular hypothesis based on carbohydrate-carbohydrate interactions
has PubMed Central identifier	PMC7395945
schema:publication	Med Hypotheses
resource representing a document's body	covid:e394bb1508e17cd28216b998cf2822f611ac4b45#body_text
is schema:about of	named entity 'hypothesize' named entity 'binding' named entity 'Recent' named entity 'Virus' named entity 'distribution' named entity 'manifestation' named entity 'induced' named entity 'correlation' named entity 'bibliographic' named entity 'Journal' named entity 'RECEPTORS' named entity 'NTD' named entity 'BLOOD SYSTEM' named entity 'SARS-COV-2' named entity 'BETTER' named entity 'PROTEIN BINDING' named entity 'FUTURE' named entity 'coronavirus' named entity 'studies' named entity 'caused' named entity 'SARS-CoV-2' named entity 'history' named entity 'glycoproteins' named entity 'interactions' named entity 'infection' named entity 'molecular' named entity 'blood system' named entity 'ACE2 receptor' named entity 'progression' named entity 'receptors' named entity 'susceptible' named entity 'Spike' named entity 'susceptibility' named entity 'infection' named entity 'infection' named entity 'virion' named entity 'monomer' named entity 'homotrimer' named entity 'carbohydrate' named entity 'RBD' named entity 'SARS-CoV-2' named entity 'ACE2 receptor' named entity 'CD147' named entity 'carbohydrate' named entity 'maximize' named entity 'virulence factor' named entity 'blood glucose' named entity 'SARS-CoV-2' named entity 'zinc' named entity 'glycoproteins' named entity 'viral coat' named entity 'ABO blood groups' named entity 'coronaviruses' named entity 'histo' named entity 'Spike protein' named entity 'viral entry' named entity 'blood type' named entity 'cell types' named entity 'glycans' named entity 'virus' named entity 'respiratory tract' named entity 'sialic acid' named entity 'marine sponge' named entity 'MERS-CoV' named entity 'Receptor' named entity 'TMPRSS2' named entity 'host cell' named entity 'cell types' named entity 'red blood cells' named entity 'coronavirus' named entity 'virus' named entity 'galactose' named entity 'neurological disorders' named entity 'cardiovascular disease' named entity 'transmembrane receptors' named entity 'H antigen' named entity 'hyperlipidemia' named entity 'coagulation' named entity 'pathogenicity' named entity 'advanced stages'

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