About: Delaying haematopoietic stem cell transplantation in children with viral respiratory infections reduces transplant‐related mortality

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About: Delaying haematopoietic stem cell transplantation in children with viral respiratory infections reduces transplant‐related mortality Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Delaying haematopoietic stem cell transplantation in children with viral respiratory infections reduces transplant‐related mortality
Creator	Breuer, Judith Rao, Kanchan Veys, Paul Amrolia, Persis Chiesa, Robert Ciocarlie, Oana Elfeky, Reem Lazareva, Arina Lucchini, Giovanna Ottaviano, Giorgio Furtado-Silva, Juliana
Source	Medline; PMC
abstract	Viral respiratory infections (VRIs) contribute to the morbidity and transplant‐related mortality (TRM) after allogeneic haematopoietic stem cell transplantation (HSCT) and strategies to prevent and treat VRIs are warranted. We monitored VRIs before and after transplant in children undergoing allogeneic HSCT with nasopharyngeal aspirates (NPA) and assessed the impact on clinical outcome. Between 2007 and 2017, 585 children underwent 620 allogeneic HSCT procedures. Out of 75 patients with a positive NPA screen (12%), transplant was delayed in 25 cases (33%), while 53 children started conditioning with a VRI. Patients undergoing HSCT with a positive NPA screen had a significantly lower overall survival (54% vs. 79%) and increased TRM (26% vs. 7%) compared to patients with a negative NPA. Patients with a positive NPA who delayed transplant and cleared the virus before conditioning had improved overall survival (90%) and lower TRM (5%). Pre‐HSCT positive NPA was the only significant risk factor for progression to a lower respiratory tract infection and was a major risk factor for TRM. Transplant delay, whenever feasible, in case of a positive NPA screen for VRIs can positively impact on survival of children undergoing HSCT.
has issue date	2019-09-30(xsd:dateTime)
bibo:doi	10.1111/bjh.16216
bibo:pmid	31566733
has license	no-cc
sha1sum (hex)	e3a849271bcac55ae315d49831c7f92dd49cc4b0
schema:url	https://doi.org/10.1111/bjh.16216
resource representing a document's title	Delaying haematopoietic stem cell transplantation in children with viral respiratory infections reduces transplant‐related mortality
has PubMed Central identifier	PMC7161889
has PubMed identifier	31566733
schema:publication	Br J Haematol
resource representing a document's body	covid:e3a849271bcac55ae315d49831c7f92dd49cc4b0#body_text
is schema:about of	named entity 'TRM' named entity 'delayed' named entity 'HSCT' named entity 'VRIs' named entity 'Transplant' named entity 'stem cell' named entity 'reduces' named entity 'viral' named entity 'IMPACT' named entity 'TRANSPLANT-RELATED MORTALITY' named entity 'HAEMATOPOIETIC STEM CELL TRANSPLANTATION' named entity 'TRM' named entity 'TRANSPLANT' named entity 'INCREASED' named entity 'LOWER' named entity 'RESPIRATORY INFECTIONS' named entity 'CHILDREN' covid:arg/e3a849271bcac55ae315d49831c7f92dd49cc4b0 named entity 'prevent' named entity 'transplant' named entity 'infection' named entity 'cases' named entity 'negative' named entity 'risk factor' named entity 'Patients' named entity 'positive' named entity 'case' named entity 'progression' named entity 'patients' named entity 'started' named entity 'HSCT' named entity 'clinical outcome' named entity 'allogeneic' named entity 'virus' named entity 'PID' named entity 'lower respiratory tract infection' named entity 'HSCT' named entity 'immunosuppressants' named entity 'upper respiratory tract infection' named entity 'HSCT' named entity 'risk factor' named entity 'bone marrow' named entity 'bronchoalveolar lavage' named entity 'RSV' named entity 'severe infections' named entity 'pulmonary complications' named entity 'VRIs' named entity 'URTI' named entity 'respiratory distress' named entity 'VRIs' named entity 'morbidity' named entity 'viral infection' named entity 'upper airways' named entity 'VRIs' named entity 'clinical outcome' named entity 'viruses' named entity 'gamma/delta' named entity 'HSCT' named entity 'HSCT' named entity 'prophylaxis' named entity 'GvHD' named entity 'HSCT' named entity 'adenovirus' named entity 'LRTI' named entity 'HSCT' named entity 'respiratory failure' named entity 'HSCT' named entity 'HSCT' named entity 'URTIs' named entity 'VRIs' named entity 'respiratory symptoms'

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