About: Regulation of nucleocytoplasmic trafficking of viral proteins: An integral role in pathogenesis?

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Regulation of nucleocytoplasmic trafficking of viral proteins: An integral role in pathogenesis? Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Regulation of nucleocytoplasmic trafficking of viral proteins: An integral role in pathogenesis?
Creator	Jans, David Fulcher, Alex
Source	Elsevier; Medline; PMC
abstract	Abstract Signal-dependent targeting of proteins into and out of the nucleus is mediated by members of the importin (IMP) family of transport receptors, which recognise targeting signals within a cargo protein and mediate passage through the nuclear envelope-embedded nuclear pore complexes. Regulation of this process is paramount to processes such as cell division and differentiation, but is also critically important for viral replication and pathogenesis; phosphorylation appears to play a major role in regulating viral protein nucleocytoplasmic trafficking, along with other posttranslational modifications. This review focuses on viral proteins that utilise the host cell IMP machinery in order to traffic into/out of the nucleus, and in particular those where trafficking is critical to viral replication and/or pathogenesis, such as simian virus SV40 large tumour antigen (T-ag), human papilloma virus E1 protein, human cytomegalovirus processivity factor ppUL44, and various gene products from RNA viruses such as Rabies. Understanding of the mechanisms regulating viral protein nucleocytoplasmic trafficking is paramount to the future development of urgently needed specific and effective anti-viral therapeutics. This article was originally intended for the special issue “Regulation of Signaling and Cellular Fate through Modulation of Nuclear Protein Import”. The Publisher apologizes for any inconvenience caused.
has issue date	2011-12-31(xsd:dateTime)
bibo:doi	10.1016/j.bbamcr.2011.03.019
bibo:pmid	21530593
has license	els-covid
sha1sum (hex)	e3c2df2221f21ddbb5ece5f094fa307e26b79e9e
schema:url	https://doi.org/10.1016/j.bbamcr.2011.03.019
resource representing a document's title	Regulation of nucleocytoplasmic trafficking of viral proteins: An integral role in pathogenesis?
has PubMed Central identifier	PMC7114211
has PubMed identifier	21530593
schema:publication	Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
resource representing a document's body	covid:e3c2df2221f21ddbb5ece5f094fa307e26b79e9e#body_text
is schema:about of	named entity 'ROLE' named entity 'posttranslational modifications' named entity 'focuses' named entity 'tumour antigen' named entity 'mediate' named entity 'pathogenesis' named entity 'regulating' named entity 'machinery' named entity 'CRITICAL' named entity 'SPECIAL' named entity 'ARTICLE' named entity 'REVIEW' named entity 'MEMBERS' named entity 'CARGO' named entity 'SIMIAN VIRUS' named entity 'SPECIFIC' named entity 'INTEGRAL' named entity 'LARGE TUMOUR' named entity 'NUCLEAR ENVELOPE' named entity 'DEPENDENT' named entity 'WHERE' named entity 'BUT' named entity 'UNDERSTANDING' named entity 'MODULATION' named entity 'RABIES' named entity 'PROTEINS' named entity 'TRAFFIC' named entity 'CELLULAR' named entity 'FATE' named entity 'TRAFFICKING' named entity 'TARGETING' named entity 'FAMILY' named entity 'PUBLISHER' named entity 'ROLE' named entity 'ORDER' named entity 'NUCLEAR PORE' named entity 'PROTEIN ' named entity 'VIRAL PROTEINS' named entity 'REGULATION' named entity 'CAUSED' named entity 'TRANSPORT' named entity 'ISSUE' named entity 'PLAY' named entity 'POSTTRANSLATIONAL' named entity 'RECEPTORS' named entity 'FACTOR' named entity 'PROTEIN IMPORT' named entity 'FUTURE' named entity 'EMBEDDED' named entity 'PARTICULAR' named entity 'SV40' named entity 'PROCESS' named entity 'IMPORTANT' named entity 'HOST CELL' named entity 'NUCLEAR PROTEIN' named entity 'VIRAL' named entity 'MEDIATE' named entity 'COMPLEXES' named entity 'TUMOUR ANTIGEN' named entity 'MECHANISMS' named entity 'DEVELOPMENT' named entity 'GENE' named entity 'VIRAL PROTEINS' named entity 'MACHINERY' named entity 'DIFFERENTIATION' named entity 'VARIOUS' named entity 'PASSAGE' named entity 'NUCLEUS' named entity 'NEEDED' named entity 'EFFECTIVE' named entity 'INTENDED' named entity 'CELL DIVISION' named entity 'VIRAL REPLICATION' named entity 'PRODUCTS' named entity 'REGULATING' named entity 'IMPORTIN' named entity 'PATHOGENESIS' named entity 'TRAFFICKING' named entity 'RNA VIRUSES' named entity 'REGULATION'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software