About: Crystal structure of murine sCEACAM1a[1,4]: a coronavirus receptor in the CEA family

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About: Crystal structure of murine sCEACAM1a[1,4]: a coronavirus receptor in the CEA family Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Crystal structure of murine sCEACAM1a[1,4]: a coronavirus receptor in the CEA family
Creator	Zhang, Rongguang Joachimiak, Andrzej Duke, Norma Meijers, Rob Tan, Kemin Bergelson, Jeffrey Holmes, Kathryn Liu, Jin-Huan Meijers, R Tan, K Wang, Jia-Huai Zelus, B Zelus, Bruce
source	Medline; PMC
abstract	CEACAM1 is a member of the carcinoembryonic antigen (CEA) family. Isoforms of murine CEACAM1 serve as receptors for mouse hepatitis virus (MHV), a murine coronavirus. Here we report the crystal structure of soluble murine sCEACAM1a[1,4], which is composed of two Ig-like domains and has MHV neutralizing activity. Its N-terminal domain has a uniquely folded CC′ loop that encompasses key virus-binding residues. This is the first atomic structure of any member of the CEA family, and provides a prototypic architecture for functional exploration of CEA family members. We discuss the structural basis of virus receptor activities of murine CEACAM1 proteins, binding of Neisseria to human CEACAM1, and other homophilic and heterophilic interactions of CEA family members.
has issue date	2002-05-01(xsd:dateTime)
bibo:doi	10.1093/emboj/21.9.2076
bibo:pmid	11980704
has license	green-oa
sha1sum (hex)	e3d0d482ebd9a8ba81c254cc433f314142e72174
schema:url	https://doi.org/10.1093/emboj/21.9.2076
resource representing a document's title	Crystal structure of murine sCEACAM1a[1,4]: a coronavirus receptor in the CEA family
has PubMed Central identifier	PMC125375
has PubMed identifier	11980704
schema:publication	The EMBO Journal
resource representing a document's body	covid:e3d0d482ebd9a8ba81c254cc433f314142e72174#body_text
is schema:about of	named entity 'activities' named entity 'interactions' named entity 'CEA' named entity 'family' named entity 'Ig-like domains' named entity 'neutralizing' named entity 'FOLDED' named entity 'CRYSTAL STRUCTURE' named entity 'FAMILY MEMBERS' named entity 'WORK' named entity 'HOMOPHILIC' named entity 'MURINE' named entity 'NEISSERIA' named entity 'RECEPTORS' named entity 'BINDING' named entity 'COMPOSED OF' named entity 'REPORT' named entity 'LOOP' named entity 'DOMAIN' named entity 'ACTIVITIES' named entity 'ISOFORMS' named entity 'CEACAM1' named entity 'STRUCTURAL' named entity 'PROVIDES' named entity 'ATOMIC STRUCTURE' named entity 'MOUSE HEPATITIS VIRUS' named entity 'FAMILY' named entity 'SOLUBLE' named entity 'SERVE' named entity 'ARCHITECTURE' named entity 'ACTIVITY' named entity 'INTERACTIONS' named entity 'ITS' named entity 'VIRUS RECEPTOR' named entity 'LIKE' named entity 'HERE' named entity 'IS A' named entity 'PROTEINS' named entity 'HUMAN' named entity 'CEA' named entity 'MEMBER OF' named entity 'BASIS' named entity 'MURINE CORONAVIRUS' named entity '5B1' named entity 'HETEROPHILIC' named entity 'N-TERMINAL ' named entity 'KEY' named entity 'DISCUSS' named entity '2C4' named entity 'FUNCTIONAL EXPLORATION' named entity 'CARCINOEMBRYONIC ANTIGEN' named entity 'virus' named entity 'family' named entity 'proteins' named entity 'MHV' named entity 'CEACAM1' named entity 'murine' named entity 'CEA' named entity 'CEACAM1' named entity 'Neisseria' named entity 'CEA' named entity 'MHV' named entity 'A59' named entity 'Asp' named entity 'N-glycosylation sites' named entity 'virulent' named entity 'BLAST search' named entity 'conformation' named entity 'MHV'

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