About: Host genes regulate transcription of sperm-introduced hepatitis B virus genes in embryo

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Host genes regulate transcription of sperm-introduced hepatitis B virus genes in embryo Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Host genes regulate transcription of sperm-introduced hepatitis B virus genes in embryo
Creator	Zhong, Ying Han, Ting-Ting Hou, Zhi-Wei Huang, Ji-Hua Huang, Tian-Hua Li, Peng-Hao Liu, Dong-Ling Xie, Qing-Dong Xu, Xiao-Qing Zeng, Fei Zhong, Chen-Yao Zhou, Xiao-Ling Ahmed, Morsi, Mohamed
Source	Elsevier; Medline; PMC
abstract	Abstract Hepatitis B virus (HBV) can invade the male germline, and sperm-introduced HBV genes could be transcribed in embryo. This study was to explore whether viral gene transcription is regulated by host genes. Embryos were produced by in vitro fertilization of hamster oocytes with human sperm containing the HBV genome. Total RNA extracted from test and control embryos were subjected to SMART-PCR, SSH, microarray hybridization, sequencing and BLAST analysis. Twenty-nine sequences showing significant identity to five human gene families were identified, with CSH2, EIF4G2, PCBD2, PSG4 and TTN selected to represent target genes. Using qRT-PCR, when CSH2 and PCBD2 (or EIF4G2, PSG4 and TTN) were silenced by RNAi, transcriptional levels of HBV s and x genes decreased (or increased). This is the first report that host genes participate in regulation of sperm-introduced HBV gene transcription in embryo, which is critical to prevent negative impact of HBV infection on early embryonic development.
has issue date	2017-10-31(xsd:dateTime)
bibo:doi	10.1016/j.reprotox.2017.08.009
bibo:pmid	28822827
has license	els-covid
sha1sum (hex)	e404cb983d564e8297fe573cfb369c3ee41f0685
schema:url	https://doi.org/10.1016/j.reprotox.2017.08.009
resource representing a document's title	Host genes regulate transcription of sperm-introduced hepatitis B virus genes in embryo
has PubMed Central identifier	PMC7127588
has PubMed identifier	28822827
schema:publication	Reproductive Toxicology
resource representing a document's body	covid:e404cb983d564e8297fe573cfb369c3ee41f0685#body_text
is schema:about of	named entity 'EMBRYO' named entity 'genes' named entity 'qRT-PCR' named entity 'microarray' named entity 'selected' named entity 'gene' named entity 'extracted' named entity 'hepatitis B virus' named entity 'embryo' named entity 'TRANSCRIPTION' named entity 'GENE TRANSCRIPTION' named entity 'REPORT' named entity 'HOST' named entity 'GENE FAMILIES' named entity 'SPERM' named entity 'TEST' named entity 'EIF4G2' named entity 'GENOME' named entity 'RNAI' named entity 'DECREASED' named entity 'GERMLINE' named entity 'IDENTIFIED' named entity 'QRT-PCR' named entity 'IN VITRO FERTILIZATION ' named entity 'PSG4' named entity 'HEPATITIS B VIRUS' named entity 'TOTAL RNA' named entity 'IMPACT' named entity 'LEVELS' named entity 'HUMAN GENE' named entity 'TO PREVENT' named entity 'CRITICAL' named entity 'INVADE' named entity 'PCBD2' named entity 'TRANSCRIBED' named entity 'SSH' named entity 'EMBRYOS' named entity 'MICROARRAY' named entity 'REGULATE' named entity 'HEPATITIS B VIRUS' named entity 'HBV INFECTION' named entity 'TARGET' named entity 'HOST' named entity 'GENES' named entity 'INTRODUCED' named entity 'REGULATED' named entity 'CONTROL' named entity 'HYBRIDIZATION' named entity 'USING' named entity 'TTN' named entity 'SMART' named entity 'IDENTITY' named entity 'VIRAL GENE' named entity 'EMBRYO' named entity 'INCREASED' named entity 'MALE' named entity 'HAMSTER' named entity 'EXTRACTED' named entity 'PCR' named entity 'CONTAINING' named entity 'GENES' named entity 'SEQUENCES' named entity 'SEQUENCING' named entity 'STUDY' named entity 'COULD BE' named entity 'SELECTED' named entity 'CSH2' named entity 'REGULATION'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software