About: Distinct systems serology features in children, elderly and COVID patients

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Distinct systems serology features in children, elderly and COVID patients Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Distinct systems serology features in children, elderly and COVID patients
Creator	Krammer, Florian Watterson, Daniel Hensen, Luca Kedzierska, Katherine Juno, Jennifer Cheng, Chua, Brendon Jackson, David Nguyen, Thi Wheatley, Adam Wong, Young, Paul Doolan, Denise Flanagan, Katie Kent, Stephen Van De Sandt, Carolien Amanat, Fatima Arnold, Kelly Chappell, Keith Chinn, Yi Chung, Amy Crowe, Jane Hogarth, P Kelly, Hannah Lee, Christina Lemke, Melissa Marios, Rowntree, Louise Selva, Kevin Shoffner, Tan, Hyon-Xhi Wines, Bruce
Source	MedRxiv
abstract	SARS-CoV-2, the pandemic coronavirus that causes COVID-19, has infected millions worldwide, causing unparalleled social and economic disruptions. COVID-19 results in higher pathogenicity and mortality in the elderly compared to children. Examining baseline SARS-CoV-2 cross-reactive coronavirus immunological responses, induced by circulating human coronaviruses, is critical to understand such divergent clinical outcomes. The cross-reactivity of coronavirus antibody responses of healthy children (n=89), adults (n=98), elderly (n=57), and COVID-19 patients (n=19) were analysed by systems serology. While moderate levels of cross-reactive SARS-CoV-2 IgG, IgM, and IgA were detected in healthy individuals, we identified serological signatures associated with SARS-CoV-2 antigen-specific Fc{gamma} receptor binding, which accurately distinguished COVID-19 patients from healthy individuals and suggested that SARS-CoV-2 induces qualitative changes to antibody Fc upon infection, enhancing Fc{gamma} receptor engagement. Vastly different serological signatures were observed between healthy children and elderly, with markedly higher cross-reactive SARS-CoV-2 IgA and IgG observed in elderly, whereas children displayed elevated SARS-CoV-2 IgM, including receptor binding domain-specific IgM with higher avidity. These results suggest that less-experienced humoral immunity associated with higher IgM, as observed in children, may have the potential to induce more potent antibodies upon SARS-CoV-2 infection. These key insights will inform COVID-19 vaccination strategies, improved serological diagnostics and therapeutics.
has issue date	2020-05-18(xsd:dateTime)
bibo:doi	10.1101/2020.05.11.20098459
has license	medrxiv
sha1sum (hex)	e418f3884e7e78ab596ff625fc4de9401b535b66
schema:url	https://doi.org/10.1101/2020.05.11.20098459
resource representing a document's title	Distinct systems serology features in children, elderly and COVID patients
resource representing a document's body	covid:e418f3884e7e78ab596ff625fc4de9401b535b66#body_text
is schema:about of	named entity 'infection' named entity 'coronavirus' named entity 'coronavirus' named entity 'observed' named entity 'cross-reactive' named entity 'serological' named entity 'SARS-CoV-2' named entity 'enhancing' named entity 'cross-reactive' named entity 'accurately' named entity 'individuals' named entity 'detected' named entity 'induces' named entity 'serology' named entity 'qualitative' named entity 'COVID-19' named entity 'IgA' named entity 'Fcγ receptor' named entity 'cross-reactivity' named entity 'COVID' named entity 'serological' named entity 'SARS-CoV-2' named entity 'IgM' named entity 'serological' named entity 'COVID-19' named entity 'serology' named entity 'SARS-CoV-2' named entity 'ADCP' named entity 'preprint' named entity 'medRxiv' named entity 'NL63' named entity 'HLA' named entity 'SARS-CoV-1' named entity 'doi' named entity 'SARS-CoV-2' named entity 'IgG' named entity 'hemagglutinin' named entity 'preprint' named entity 'Statistical significance' named entity 'antigens' named entity 'Elastic Net' named entity 'preprint' named entity 'doi' named entity 'RBD' named entity 'preprint' named entity 'antigen' named entity 'SARS-CoV-1' named entity 'preprint' named entity 'SARS-CoV-2' named entity 'COVID' named entity 'antigens' named entity 'medRxiv' named entity 'IgA' named entity 'carboxylated'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software