About: A Modular Microarray Imaging System for Highly Specific COVID-19 Antibody Testing

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About: A Modular Microarray Imaging System for Highly Specific COVID-19 Antibody Testing Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A Modular Microarray Imaging System for Highly Specific COVID-19 Antibody Testing
Creator	Jain, Aarti Gratton, Enrico Felgner, Philip Khan, Saahir Nakajima, Rie Ramiro De Assis, Rafael Jasinskas, Algis Abram, Timothy Hedde, Niklas Pearce, Trevor Toosky, Melody Zhao, Weian
topic	covid:e4384f263f004b328db50697fe6f76384f2a6631#this
Source	BioRxiv; Medline; PMC
abstract	To detect the presence of antibodies in blood against SARS-CoV-2 in a highly sensitive and specific manner, here we describe a robust, inexpensive ($200), 3D-printable portable imaging platform (TinyArray imager) that can be deployed immediately in areas with minimal infrastructure to read coronavirus antigen microarrays (CoVAMs) that contain a panel of antigens from SARS-CoV-2, SARS-1, MERS, and other respiratory viruses. Application includes basic laboratories and makeshift field clinics where a few drops of blood from a finger prick could be rapidly tested in parallel for the presence of antibodies to SARS-CoV-2 with a test turnaround time of only 2–4 h. To evaluate our imaging device, we probed and imaged coronavirus microarrays with COVID-19-positive and negative sera and achieved a performance on par with a commercial microarray reader 100x more expensive than our imaging device. This work will enable large scale serosurveillance, which can play an important role in the months and years to come to implement efficient containment and mitigation measures, as well as help develop therapeutics and vaccines to treat and prevent the spread of COVID-19.
has issue date	2020-05-23(xsd:dateTime)
bibo:doi	10.1101/2020.05.22.111518
bibo:pmid	32511369
has license	cc-by-nc-nd
sha1sum (hex)	e4384f263f004b328db50697fe6f76384f2a6631
schema:url	https://doi.org/10.1101/2020.05.22.111518
resource representing a document's title	A Modular Microarray Imaging System for Highly Specific COVID-19 Antibody Testing
has PubMed Central identifier	PMC7263497
has PubMed identifier	32511369
schema:publication	bioRxiv
resource representing a document's body	covid:e4384f263f004b328db50697fe6f76384f2a6631#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/e4384f263f004b328db50697fe6f76384f2a6631
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