About: Preliminary Data Related to the Effect of Climacostol Produced by the Freshwater Ciliate Climacostomum virens on Human Adenovirus

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About: Preliminary Data Related to the Effect of Climacostol Produced by the Freshwater Ciliate Climacostomum virens on Human Adenovirus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Preliminary Data Related to the Effect of Climacostol Produced by the Freshwater Ciliate Climacostomum virens on Human Adenovirus
Creator	Carducci, Annalaura Verani, Marco Buonanno, Federico Di Giuseppe, Graziano Federigi, Ileana Ortenzi, Claudio
Source	Medline; PMC
abstract	The new epidemiological scenario has so far focused on the environmental circulation of human viral pathogens. Owing to the side effects of chemical disinfectants, there is an increasing need for knowledge on the use of virucidal compounds, especially those of a natural origin. Climacostol is a molecule produced by a freshwater ciliate and it exhibits activity against bacterial and fungal pathogens. We thus also speculated that there might be an effect on viral viability, which has never been tested. To evaluate such activity, we chose human adenovirus (HAdV), which is representative of waterborne viruses. We conducted experiments using HAdV serotype 5, whose titer was determined by infecting HeLa cell cultures. HAdV5 was shown to be sensitive to climacostol at a concentration of 0.0002 mg/mL, with an approximate 3 Log(10) reduction when the initial titer of HAdV5 was approximately 10(4) and 10(3) TCID(50)/mL. These preliminary results could be an important starting point for further research aimed at improving the characterization of climacostol activity under different experimental conditions and against various viruses, including enveloped ones (i.e., the coronavirus). The production of climacostol by a protist living in fresh water also suggests a possible application in the activated sludge of wastewater treatment plants.
has issue date	2020-06-18(xsd:dateTime)
bibo:doi	10.3390/v12060658
bibo:pmid	32570859
has license	cc-by
sha1sum (hex)	e448a7fcd26f339930868c65d1a7c34c6191775e
schema:url	https://doi.org/10.3390/v12060658
resource representing a document's title	Preliminary Data Related to the Effect of Climacostol Produced by the Freshwater Ciliate Climacostomum virens on Human Adenovirus
has PubMed Central identifier	PMC7354546
has PubMed identifier	32570859
schema:publication	Viruses
resource representing a document's body	covid:e448a7fcd26f339930868c65d1a7c34c6191775e#body_text
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