About: A Peptide-Based Virus Inactivator Protects Male Mice Against Zika Virus-Induced Damage of Testicular Tissue

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A Peptide-Based Virus Inactivator Protects Male Mice Against Zika Virus-Induced Damage of Testicular Tissue
Creator	Jiang, Shibo Lu, Lu Xu, Wei Rong, Lijun Wang, Qian Li, Weihua Zou, Peng Wang, Tian Hu, Jingying Meng, Yu Si, Lulu Wang, Yuzhu Xia, Minjie Li, Tian Ojcius, David Meng, Si
Source	Medline; PMC
abstract	Zika virus (ZIKV) was a re-emerging arbovirus associated with Guillain–Barré Syndrome in adult and congenital Zika syndrome in fetus and infant. Although ZIKV was mainly transmitted by mosquito bites, many sexual transmission cases have been reported since the outbreak in 2015. ZIKV can persist in testis and semen for a long time, causing testicular tissue damage and reducing sperm quality. However, no drug has been approved for prevention or treatment of ZIKV infection, especially infection in male testicular tissue. Previously reported peptide Z2 could inactivate ZIKV, inhibiting ZIKV infection in vitro and in vivo. Importantly, Z2 could inhibit vertical transmission of ZIKV in pregnant mice, reducing ZIKV infection in fetus. Here we showed that intraperitoneally administered Z2 could also be distributed to testis and epididymis, resulting in the reduction of ZIKV RNA copies in testicular tissue and protection of testis and epididymis against ZIKV-induced pathological damage and poor sperm quality in type I interferon receptor-deficient A129 mice. Thus, Z2, a ZIKV inactivator, could serve as an antiviral agent for treatment of ZIKV infection and attenuation of ZIKV-induced testicular tissue damage.
has issue date	2019-09-27(xsd:dateTime)
bibo:doi	10.3389/fmicb.2019.02250
bibo:pmid	31611865
has license	cc-by
sha1sum (hex)	e4813a9f4fee2d74c954d90bed67e8738047a390
schema:url	https://doi.org/10.3389/fmicb.2019.02250
resource representing a document's title	A Peptide-Based Virus Inactivator Protects Male Mice Against Zika Virus-Induced Damage of Testicular Tissue
has PubMed Central identifier	PMC6777420
has PubMed identifier	31611865
schema:publication	Front Microbiol
resource representing a document's body	covid:e4813a9f4fee2d74c954d90bed67e8738047a390#body_text
is schema:about of	named entity 'DAMAGE' named entity 'semen' named entity 'cases' named entity 'Although' named entity 'intraperitoneally' named entity 'ZIKA VIRUS' named entity 'VIRUS' named entity 'IN VITRO' named entity 'APPROVED' named entity 'MOSQUITO BITES' named entity 'IN VIVO' named entity 'CASES' named entity 'ADMINISTERED' named entity 'SYNDROME' named entity 'ARBOVIRUS' named entity 'ANTIVIRAL AGENT' named entity 'DRUG' named entity 'SEMEN' named entity 'PATHOLOGICAL' named entity 'WAS A' named entity 'RESULTING IN' named entity 'CAUSING' named entity 'ASSOCIATED WITH' named entity 'TESTIS' named entity 'SEXUAL TRANSMISSION' named entity 'SERVE' named entity 'PREVENTION' named entity 'HERE' named entity 'MICE' named entity 'TESTICULAR TISSUE' named entity 'ZIKA VIRUS' named entity 'LONG' named entity 'PREGNANT' named entity 'RNA' named entity 'CONGENITAL ZIKA SYNDROME' named entity 'INDUCED' named entity 'VERTICAL TRANSMISSION' named entity 'ADULT' named entity 'PREVIOUSLY' named entity 'INDUCED' named entity 'BASED' named entity 'CITATION' named entity 'MALE' named entity 'MICE' named entity 'REDUCTION' named entity 'INFANT' named entity 'ATTENUATION' named entity 'POOR' named entity '2015' named entity 'COPIES' named entity 'FETUS' named entity 'REPORTED' named entity 'PROTECTION' named entity 'DAMAGE' named entity 'TIME' named entity 'BARR' named entity 'TESTICULAR TISSUE' named entity 'PEPTIDE' named entity 'INHIBITING' named entity 'DISTRIBUTED' named entity 'DEFICIENT' named entity 'TISSUE DAMAGE' named entity 'HAVE' named entity 'OUTBREAK' named entity 'MALE' named entity 'TYPE I INTERFERON RECEPTOR'

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