About: Comparative studies of the expression of creatine kinase isoforms under immune stress in Pelodiscus sinensis

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About: Comparative studies of the expression of creatine kinase isoforms under immune stress in Pelodiscus sinensis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Comparative studies of the expression of creatine kinase isoforms under immune stress in Pelodiscus sinensis
Creator	Wang, Wei Yang, Yufei Lee, Jinhyuk Li, Caiyan Park, Yong-Doo Qian, Guo-Ying Yin, Shang-Jun Zeng, Lifang
Source	Elsevier; Medline; PMC
abstract	The expression and localization of different isoforms of creatine kinase in Pelodiscus sinensis (PSCK) were studied to reveal the role of PSCK isozymes (PSCK-B, PSCK-M, PSCK-S) under bacterial infection-induced immunologic stress. The computational molecular dynamics simulations predicted that PSCK-S would mostly possess a kinase function in a structural aspect when compared to PSCK-B and PSCK-M. The assay of biochemical parameters such as total superoxide dismutase (T-SOD), lactate dehydrogenase (LDH), malondialdehyde (MDA), catalase (CAT), and the content of ATP were measured along with total PSCK activity in different tissue samples under bacterial infection. The expression detections of PSCK isozymes in vitro and in vivo were overall well-matched where PSCK isozymes were expressed differently in P. sinensis tissues. The results showed that PSCK-B mostly contributes to the spleen, followed by the liver and myocardium; PSCK-M mostly contributes to the liver, followed by the myocardium and skeletal muscle, while PSCK-S contributes to the spleen and is uniquely expressed in skeletal muscle. Our study suggests that the various alterations of PSCK isozymes in tissues of P. sinensis are prone to defense the bacterial infection and blocking energetic imbalance before severe pathogenesis turned on in P. sinensis.
has issue date	2020-06-09(xsd:dateTime)
bibo:doi	10.1016/j.ijbiomac.2020.06.036
bibo:pmid	32531365
has license	no-cc
sha1sum (hex)	e4886cfcbdbbddc510123a4d92d8a9ab94bab9f9
schema:url	https://doi.org/10.1016/j.ijbiomac.2020.06.036
resource representing a document's title	Comparative studies of the expression of creatine kinase isoforms under immune stress in Pelodiscus sinensis
has PubMed Central identifier	PMC7282771
has PubMed identifier	32531365
schema:publication	Int J Biol Macromol
resource representing a document's body	covid:e4886cfcbdbbddc510123a4d92d8a9ab94bab9f9#body_text
is schema:about of	named entity 'imbalance' named entity 'bacterial infection' named entity 'suggested' named entity 'samples' named entity 'P. sinensis' named entity 'reduced' named entity 'metabolic' named entity 'Comparative' named entity 'GenBank' named entity 'immune response' named entity 'ADP' named entity 'liver' named entity 'type II' named entity 'malondialdehyde' named entity 'foot' named entity 'molecular dynamics' named entity 'CAT' named entity 'total' named entity 'lactate dehydrogenase' named entity 'Pelodiscus sinensis' named entity 'Journal' named entity 'kinase' named entity 'adenosine triphosphate' named entity 'Journal' named entity 'LDH' named entity 'cases' named entity 'Our' named entity 'Abbreviations' named entity 'brain' named entity 'studies' named entity 'Journal' named entity 'CAT' named entity 'spleen' named entity 'bacterial infection' named entity 'catalase' named entity 'isoforms' named entity 'RT-PCR' named entity 'Pelodiscus sinensis' named entity 'mitochondrial' named entity 'sarcomeric' named entity 'immune response' named entity 'hand, foot and mouth disease' named entity 'picosecond' named entity 'bacterial infection' named entity 'Pelodiscus sinensis' named entity 'superoxide dismutase' named entity 'isoenzyme' named entity 'malondialdehyde' named entity 'isozymes' named entity 'liver' named entity 'P. sinensis' named entity 'myocardium' named entity 'creatine kinase' named entity 'isoforms' named entity 'Pelodiscus sinensis' named entity 'CAT' named entity 'LDH' named entity 'ATP' named entity 'myocardium' named entity 'catalyzes' named entity 'isozyme' named entity 'LDH' named entity 'isozymes' named entity 'tissue-specific expression' named entity 'statistical significance' named entity 'formaldehyde' named entity 'liver' named entity 'kidney' named entity 'infection' named entity 'smooth muscle' named entity 'isozymes' named entity 'Primer' named entity 'ADP' named entity 'skeletal muscle'

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