About: Structure-Based Design and Synthesis of Triazole-based Macrocyclic Inhibitors of Norovirus Protease: Structural, Biochemical, Spectroscopic, and Antiviral Studies

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About: Structure-Based Design and Synthesis of Triazole-based Macrocyclic Inhibitors of Norovirus Protease: Structural, Biochemical, Spectroscopic, and Antiviral Studies Goto Sponge NotDistinct Permalink

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Structure-Based Design and Synthesis of Triazole-based Macrocyclic Inhibitors of Norovirus Protease: Structural, Biochemical, Spectroscopic, and Antiviral Studies
Creator	Chang, Kyeong-Ok Kim, Yunjeong Lovell, Scott Mehzabeen, Nurjahan Alliston, Kevin Battaile, Kevin Damalanka, Vishnu Kankanamalage, Anushka Lushington, Gerald Weerawarna, Pathum Groutas, C William, +
Source	Elsevier; Medline; PMC
abstract	Outbreaks of acute gastroenteritis caused by noroviruses constitute a public health concern worldwide. To date, there are no approved drugs or vaccines for the management and prophylaxis of norovirus infections. A potentially effective strategy for the development of norovirus therapeutics entails the discovery of inhibitors of norovirus 3CL protease, an enzyme essential for noroviral replication. We describe herein the structure-based design of the first class of permeable, triazole-based macrocyclic inhibitors of norovirus 3C-like protease, as well as pertinent X-ray crystallographic, biochemical, spectroscopic, and antiviral studies.
has issue date	2016-08-01(xsd:dateTime)
bibo:doi	10.1016/j.ejmech.2016.04.013
bibo:pmid	27235842
has license	hybrid-oa
sha1sum (hex)	e4cd0379bd512b707c6c503dddb9f29c92b17625
schema:url	https://doi.org/10.1016/j.ejmech.2016.04.013
resource representing a document's title	Structure-Based Design and Synthesis of Triazole-based Macrocyclic Inhibitors of Norovirus Protease: Structural, Biochemical, Spectroscopic, and Antiviral Studies
has PubMed Central identifier	PMC4916972
has PubMed identifier	27235842
schema:publication	European Journal of Medicinal Chemistry
resource representing a document's body	covid:e4cd0379bd512b707c6c503dddb9f29c92b17625#body_text
is schema:about of	named entity 'DRUGS' named entity 'DEVELOPMENT' named entity 'VACCINES' named entity 'LIKE' named entity 'NOROVIRUSES' named entity 'REPLICATION' named entity 'ENZYME' named entity 'NOROVIRUS' named entity 'INHIBITORS' named entity 'DESIGN' named entity 'NOROVIRUS INFECTIONS' named entity 'ACUTE GASTROENTERITIS' named entity 'BIOCHEMICAL' named entity 'STRUCTURAL' named entity 'SYNTHESIS' named entity 'BASED' named entity 'INHIBITORS' named entity 'TRIAZOLE' named entity 'DESIGN' named entity 'CONCERN' named entity 'WORLDWIDE' named entity 'PROTEASE' named entity 'ANTIVIRAL' named entity 'STUDIES' named entity 'PERMEABLE' named entity 'MANAGEMENT' named entity 'ANTIVIRAL' named entity 'DESCRIBE' named entity 'PROPHYLAXIS OF' named entity 'THERAPEUTICS' named entity 'PROTEASE' named entity 'STRATEGY' named entity 'CLASS' named entity 'BASED' named entity 'STRUCTURE' named entity 'OUTBREAKS' named entity 'STRUCTURE' named entity 'NOROVIRUS' named entity 'DATE' named entity 'X-RAY' named entity 'DISCOVERY' named entity 'EFFECTIVE' named entity 'BIOCHEMICAL' named entity 'TRIAZOLE' named entity 'PUBLIC HEALTH' named entity 'APPROVED' named entity 'CAUSED BY' named entity 'STUDIES' named entity 'ESSENTIAL' named entity 'macrocyclic' named entity 'triazole' named entity 'structure-based design' named entity 'vaccines' named entity 'Triazole' named entity 'active site' named entity 'norovirus' named entity 'triazole' named entity 'morbidity' named entity '3CLpro' named entity 'cyclization' named entity 'X-ray crystal structure' named entity 'HCl' named entity 'proteases' named entity 'esters' named entity 'protons' named entity 'amino acid residues' named entity 'open reading frames' named entity 'enzyme' named entity '3CLpro' named entity 'single stranded RNA'

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