About: Neutralizing antibody and protective immunity to SARS coronavirus infection of mice induced by a soluble recombinant polypeptide containing an N-terminal segment of the spike glycoprotein

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About: Neutralizing antibody and protective immunity to SARS coronavirus infection of mice induced by a soluble recombinant polypeptide containing an N-terminal segment of the spike glycoprotein Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Neutralizing antibody and protective immunity to SARS coronavirus infection of mice induced by a soluble recombinant polypeptide containing an N-terminal segment of the spike glycoprotein
Creator	Subbarao, Kanta Vogel, Leatrice Moss, Bernard Roberts, Anjeanette Bisht, Himani
Source	Elsevier; Medline; PMC
abstract	Abstract A secreted, glycosylated polypeptide containing amino acids 14 to 762 of the SARS coronavirus (SARS-CoV) spike protein and a polyhistidine tag was expressed in recombinant baculovirus-infected insect cells. Mice received the affinity-purified protein with either a saponin (QS21) or a Ribi (MPL + TDM) adjuvant subcutaneously and were challenged intranasally with SARS-CoV. Both regimens induced binding and neutralizing antibodies and protection against SARS-CoV intranasal infection. However, the best results were obtained with QS21 and protein, which provided the highest antibody as well as complete protection of the upper and lower respiratory tract.
has issue date	2005-04-10(xsd:dateTime)
bibo:doi	10.1016/j.virol.2005.01.042
bibo:pmid	15780866
has license	els-covid
sha1sum (hex)	e4e393cdc8e3a2243cbbe4e8a907bff74eea17a1
schema:url	https://doi.org/10.1016/j.virol.2005.01.042
resource representing a document's title	Neutralizing antibody and protective immunity to SARS coronavirus infection of mice induced by a soluble recombinant polypeptide containing an N-terminal segment of the spike glycoprotein
has PubMed Central identifier	PMC7111832
has PubMed identifier	15780866
schema:publication	Virology
resource representing a document's body	covid:e4e393cdc8e3a2243cbbe4e8a907bff74eea17a1#body_text
is schema:about of	named entity 'protein' named entity 'antibody' named entity 'glycosylated' named entity 'Neutralizing antibody' named entity 'CONTAINING' named entity 'PROTECTIVE IMMUNITY' named entity 'POLYHISTIDINE' named entity 'TAG' named entity 'RECEIVED' named entity 'RECOMBINANT' named entity 'RIBI' named entity 'SAPONIN' named entity 'PROVIDED' named entity 'AFFINITY' named entity 'MICE' named entity 'QS21' named entity 'RECOMBINANT' named entity 'POLYPEPTIDE' named entity 'INDUCED' named entity 'SARS CORONAVIRUS' named entity 'CORONAVIRUS INFECTION' named entity 'TERMINAL SEGMENT' named entity 'SOLUBLE' named entity 'BINDING' named entity 'PUBLISHED' named entity 'INDUCED' named entity 'RESULTS' named entity 'BACULOVIRUS' named entity 'INFECTED' named entity 'GLYCOSYLATED' named entity 'INTRANASAL INFECTION' named entity 'SARS-COV' named entity 'SARS CORONAVIRUS' named entity 'N-TERMINAL ' named entity 'AMINO ACIDS' named entity 'MICE' named entity 'COMPLETE' named entity 'PROTEIN' named entity 'SPIKE PROTEIN' named entity '762' named entity 'NEUTRALIZING ANTIBODY' named entity 'POLYPEPTIDE' named entity 'TDM' named entity 'EXPRESSED' named entity 'INSECT' named entity 'LOWER RESPIRATORY TRACT' named entity 'ADJUVANT' named entity 'PROTEIN ' named entity 'CELLS' named entity 'UPPER' named entity 'HIGHEST' named entity 'PURIFIED' named entity 'REGIMENS' named entity 'OBTAINED' named entity 'BEST' named entity 'NEUTRALIZING ANTIBODIES' named entity 'SECRETED' named entity 'ANTIBODY' named entity 'PROTECTION' named entity 'INC' named entity 'CONTAINING' named entity 'EITHER' covid:arg/e4e393cdc8e3a2243cbbe4e8a907bff74eea17a1 named entity 'SARS coronavirus' named entity 'spike' named entity 'amino acids' named entity 'intranasally' named entity 'infection' named entity 'QS21' named entity 'SARS coronavirus' named entity 'glycosylated' named entity 'subcutaneously' named entity 'Elsevier Inc.' named entity 'polyhistidine' named entity 'QS21' named entity 'glycoprotein' named entity 'N-terminal segment'

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