About: Neurological Manifestations in Critically Ill Patients With COVID-19: A Retrospective Study

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Neurological Manifestations in Critically Ill Patients With COVID-19: A Retrospective Study
Creator	Zhao, Jing Chen, Yu Chen, Huan Li, Qin Zhou, Xiang Wu, Wei Jiang, Wei Zhao, Hua Xie, Jing Zhang, Dong Li, Taisheng Xiao, Meng Wang, Jinglan Gao, Peng Ma, Jie Sun, Xuefeng Xia, Peng Cao, Wei Zhang, Hongmin Wu, Dong Li, Yongzhe Li, Xie Peng, Bin Xu, Yingchun Zhang, Shuyang Spain, Liu, Zhengyin Qin, Yan Yan, Xiaowei Carlos, San Clínico, Hospital Bai, Xiaoyin Ding, Xin Guo, Fan Han, Fei Porta-Etessam, Jesús Guerrero, Rodrigo Wang, Chunyao Xu, T Guan, Hongzhi Tian, Ran Cui, Liying Fan, Siyuan Guan, Tianjia Zhu, Yicheng León, Julián
Source	Medline; PMC
abstract	Background: The complications of coronavirus disease 2019 (COVID-19) involved multiple organs or systems, especially in critically ill patients. We aim to investigate the neurological complications in critically ill patients with COVID-19. Methods: This retrospective single-center case series analyzed critically ill patients with COVID-19 at the intensive care unit of Tongji Hospital, Wuhan, China from February 5 to April 2, 2020. Demographic data, clinical and laboratory findings, comorbidities and treatments were collected and analyzed. Results: Among 86 patients with confirmed COVID-19, 54 patients (62.8%) were male, and the mean (SD) age was 66.6 (11.1) years. Overall, 65% patients presented with at least one neurological symptom. Twenty patients (23.3%) had symptoms involving the central nervous system, including delirium, cerebrovascular diseases and hypoxic-ischemic brain injury, while 6 patients (7%) had neuromuscular involvement. Seven of 86 patients exhibited new stroke and 6 (7%) cases were ischemic. A significantly higher prevalence of antiphospholipid antibodies was observed in patients with ischemic stroke than in those without stroke (83.3 vs. 26.9%, p < 0.05). Patients with ischemic stroke were more likely to have a higher myoglobulin level, and a lower hemoglobin level. Conclusions: The clinical spectrum of neurological complications in critically ill patients with COVID-19 was broad. Stroke, delirium and neuromuscular diseases are common neurological complications of COVID-19. Physicians should pay close attention to neurological complications in critically ill patients with COVID-19.
has issue date	2020-07-10(xsd:dateTime)
bibo:doi	10.3389/fneur.2020.00806
bibo:pmid	32754114
has license	cc-by
sha1sum (hex)	e4f651f1b95646a8ab1ae334bc414bb2419e5528
schema:url	https://doi.org/10.3389/fneur.2020.00806
resource representing a document's title	Neurological Manifestations in Critically Ill Patients With COVID-19: A Retrospective Study
has PubMed Central identifier	PMC7365850
has PubMed identifier	32754114
schema:publication	Front Neurol
resource representing a document's body	covid:e4f651f1b95646a8ab1ae334bc414bb2419e5528#body_text
is schema:about of	named entity 'COVID-19' named entity 'IgG' named entity 'rhabdomyolysis' named entity 'lactate dehydrogenase' named entity 'D-Dimer' named entity 'critically ill patients' named entity 'China' named entity 'COVID' named entity 'medical history' named entity 'ICU' named entity 'infection' named entity 'CNS' named entity 'IL-2R' named entity 'COVID-19' named entity 'median survival duration' named entity 'WBC' named entity 'IgM' named entity 'cTnI' named entity 'WHO' named entity 'hyposmia' named entity 'stroke patients' named entity 'clinical features' named entity 'interquartile range' named entity 'critically ill patients' named entity 'human coronaviruses' named entity 'critically ill patients' named entity 'etiology' named entity 'anticoagulant therapy' named entity 'virus' named entity 'ischemic' named entity 'infarct' named entity 'Hubei Province' named entity 'Frontiers in Neurology' named entity 'COVID' named entity 'Analysis of variance' named entity 'neurological complications'

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