About: Shell disorder analysis predicts greater resilience of the SARS-CoV-2 (COVID-19) outside the body and in body fluids

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About: Shell disorder analysis predicts greater resilience of the SARS-CoV-2 (COVID-19) outside the body and in body fluids Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Shell disorder analysis predicts greater resilience of the SARS-CoV-2 (COVID-19) outside the body and in body fluids
Creator	Uversky, Vladimir Dunker, A Foster, James Goh, -Meng Kian, Gerard Goh's Biocomputing, A
Source	Elsevier; Medline; PMC
abstract	The coronavirus (CoV) family consists of viruses that infects a variety of animals including humans with various levels of respiratory and fecal-oral transmission levels depending on the behavior of the viruses' natural hosts and optimal viral fitness. A model to classify and predict the levels of respective respiratory and fecal-oral transmission potentials of the various viruses was built before the outbreak of MERS-CoV using AI and empirically-based molecular tools to predict the disorder level of proteins. Using the percentages of intrinsic disorder (PID) of the nucleocapsid (N) and membrane (M) proteins of CoV, the model easily clustered the viruses into three groups with the SARS-CoV (M PID = 8%, N PID = 50%) falling into Category B, in which viruses have intermediate levels of both respiratory and fecal-oral transmission potentials. Later, MERS-CoV (M PID = 9%, N PID = 44%) was found to be in Category C, which consists of viruses with lower respiratory transmission potential but with higher fecal-oral transmission capabilities. Based on the peculiarities of disorder distribution, the SARS-CoV-2 (M PID = 6%, N PID = 48%) has to be placed in Category B. Our data show however, that the SARS-CoV-2 is very strange with one of the hardest protective outer shell, (M PID = 6%) among coronaviruses. This means that it might be expected to be highly resilient in saliva or other body fluids and outside the body. An infected body is likelier to shed greater numbers of viral particles since the latter is more resistant to antimicrobial enzymes in body fluids. These particles are also likelier to remain active longer. These factors could account for the greater contagiousness of the SARS-CoV-2 and have implications for efforts to prevent its spread.
has issue date	2020-03-31(xsd:dateTime)
bibo:doi	10.1016/j.micpath.2020.104177
bibo:pmid	32244041
has license	no-cc
sha1sum (hex)	e5843db36b4d3b7b85f3fa486515d807f73234d8
schema:url	https://doi.org/10.1016/j.micpath.2020.104177
resource representing a document's title	Shell disorder analysis predicts greater resilience of the SARS-CoV-2 (COVID-19) outside the body and in body fluids
has PubMed Central identifier	PMC7118597
has PubMed identifier	32244041
schema:publication	Microb Pathog
resource representing a document's body	covid:e5843db36b4d3b7b85f3fa486515d807f73234d8#body_text
is schema:about of	named entity 'consists' named entity 'respective' named entity 'disorder' named entity 'tools' named entity 'coronaviruses' named entity 'MERS-CoV' named entity 'potentials' named entity 'COVID-19' named entity 'GROUPS' named entity 'HOSTS' named entity 'TOOLS' named entity 'PLACED' named entity 'CLUSTERED' named entity 'PREDICT' named entity 'MODEL' named entity 'RESPIRATORY' named entity 'MOLECULAR' named entity 'shell' named entity 'particles' named entity 'family' named entity 'saliva' named entity 'viral' named entity 'respiratory' named entity 'PID' named entity 'intrinsic disorder' named entity 'body' named entity 'hosts' named entity 'body' named entity 'saliva' named entity 'coronaviruses' named entity 'SARS-CoV-2' named entity 'nucleocapsid' named entity 'intrinsic disorder' named entity 'antimicrobial' named entity 'nucleocapsid' named entity 'SARS-CoV-2' named entity 'COVID' named entity 'virus' named entity 'virus' named entity 'structural proteins' named entity 'viruses' named entity 'mode of transmission' named entity 'viruses' named entity 'viral particles' named entity 'Ebola' named entity 'fecal-oral' named entity 'HIV' named entity 'pneumonia' named entity 'SARS-CoV-2' named entity 'structural proteins' named entity 'SARS-CoV' named entity 'civet cats' named entity 'Middle East' named entity 'vomit' named entity 'virulence' named entity 'nucleocapsid' named entity 'TGEV' named entity 'virus' named entity 'SARS-CoV' named entity 'nucleocapsid' named entity 'COVID' named entity 'fecal-oral transmission' named entity 'viruses' named entity 'YFV' named entity 'SARS-CoV-2' named entity 'virus' named entity 'viruses' named entity 'polio virus' named entity 'nucleocapsids' named entity 'neural networks' named entity 'lower respiratory' named entity 'virus' named entity 'doi' named entity 'sexually transmitted' named entity 'viruses' named entity 'bodily fluids'

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