About: Metagenomic next-generation sequencing of samples from pediatric febrile illness in Tororo, Uganda

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Metagenomic next-generation sequencing of samples from pediatric febrile illness in Tororo, Uganda
Creator	Langelier, Charles Byaruhanga, Oswald Dimitrov, Boris Egger, Rebecca Hsu, Jennifer Juan, Yun-Fang Kalantar, Katrina Kyohere, Mary Mpimbaza, Arthur Nakielny, Sara Ramesh, Akshaya Ruel, Theodore Sheu, Jonathan Wang, James Wilson, Michael De Bourcy, Charles Derisiid, Joseph Rosenthal, Philip
source	Medline; PMC
abstract	Febrile illness is a major burden in African children, and non-malarial causes of fever are uncertain. In this retrospective exploratory study, we used metagenomic next-generation sequencing (mNGS) to evaluate serum, nasopharyngeal, and stool specimens from 94 children (aged 2–54 months) with febrile illness admitted to Tororo District Hospital, Uganda. The most common microbes identified were Plasmodium falciparum (51.1% of samples) and parvovirus B19 (4.4%) from serum; human rhinoviruses A and C (40%), respiratory syncytial virus (10%), and human herpesvirus 5 (10%) from nasopharyngeal swabs; and rotavirus A (50% of those with diarrhea) from stool. We also report the near complete genome of a highly divergent orthobunyavirus, tentatively named Nyangole virus, identified from the serum of a child diagnosed with malaria and pneumonia, a Bwamba orthobunyavirus in the nasopharynx of a child with rash and sepsis, and the genomes of two novel human rhinovirus C species. In this retrospective exploratory study, mNGS identified multiple potential pathogens, including 3 new viral species, associated with fever in Ugandan children.
has issue date	2019-06-20(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0218318
bibo:pmid	31220115
has license	cc-by
sha1sum (hex)	e59da8ad79490ad5270928bd54c9a4d0b417d1ee
schema:url	https://doi.org/10.1371/journal.pone.0218318
resource representing a document's title	Metagenomic next-generation sequencing of samples from pediatric febrile illness in Tororo, Uganda
has PubMed Central identifier	PMC6586300
has PubMed identifier	31220115
schema:publication	PLoS One
resource representing a document's body	covid:e59da8ad79490ad5270928bd54c9a4d0b417d1ee#body_text
is schema:about of	named entity 'study' named entity 'nasopharyngeal' named entity 'diarrhea' named entity 'febrile' named entity 'retrospective' named entity 'SAMPLES' named entity 'TORORO' named entity 'FEBRILE ILLNESS' named entity 'MULTIPLE' named entity 'CAUSES' named entity 'NEXT-GENERATION SEQUENCING' named entity 'RESPIRATORY SYNCYTIAL VIRUS' named entity 'UGANDAN' named entity 'NEW' named entity 'UNCERTAIN' named entity 'PLASMODIUM FALCIPARUM' named entity 'PATHOGENS' named entity 'MONTHS' named entity 'CHILD' named entity 'NON-' named entity 'COMMON' named entity 'BURDEN' named entity 'ORTHOBUNYAVIRUS' named entity 'PNEUMONIA' named entity 'AFRICAN' named entity 'SEPSIS' named entity 'NASOPHARYNGEAL' named entity 'USED' named entity 'IDENTIFIED' named entity 'HIGHLY' named entity 'VIRAL' named entity 'PEDIATRIC' named entity 'PARVOVIRUS B19' named entity 'GENOMES' named entity 'UGANDA' named entity 'NEXT-GENERATION SEQUENCING' named entity 'EVALUATE' named entity 'DISTRICT HOSPITAL' named entity 'GENOME' named entity 'ADMITTED TO' named entity 'HUMAN RHINOVIRUS C' named entity 'RHINOVIRUSES' named entity 'REPORT' named entity 'UGANDA' named entity 'VIRUS' named entity 'MALARIA' named entity 'SPECIES' named entity 'NEAR COMPLETE' named entity 'DIARRHEA' named entity 'HUMAN HERPESVIRUS 5' named entity 'SWABS' named entity 'RASH' named entity 'MICROBES' named entity 'SERUM' named entity 'ROTAVIRUS A' named entity 'BWAMBA ORTHOBUNYAVIRUS' named entity 'EXPLORATORY STUDY' named entity 'SPECIMENS' named entity 'ASSOCIATED WITH' named entity 'NASOPHARYNX' named entity 'FEVER' named entity 'POTENTIAL' named entity 'SAMPLES' named entity 'DIAGNOSED'

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