About: Bacterial Biofilm and its Role in the Pathogenesis of Disease

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Bacterial Biofilm and its Role in the Pathogenesis of Disease
Creator	Grønseth, Torstein Nesse, Live Simm, Roger Vestby, Lene
Source	Medline; PMC
abstract	Recognition of the fact that bacterial biofilm may play a role in the pathogenesis of disease has led to an increased focus on identifying diseases that may be biofilm-related. Biofilm infections are typically chronic in nature, as biofilm-residing bacteria can be resilient to both the immune system, antibiotics, and other treatments. This is a comprehensive review describing biofilm diseases in the auditory, the cardiovascular, the digestive, the integumentary, the reproductive, the respiratory, and the urinary system. In most cases reviewed, the biofilms were identified through various imaging technics, in addition to other study approaches. The current knowledge on how biofilm may contribute to the pathogenesis of disease indicates a number of different mechanisms. This spans from biofilm being a mere reservoir of pathogenic bacteria, to playing a more active role, e.g., by contributing to inflammation. Observations also indicate that biofilm does not exclusively occur extracellularly, but may also be formed inside living cells. Furthermore, the presence of biofilm may contribute to development of cancer. In conclusion, this review shows that biofilm is part of many, probably most chronic infections. This is important knowledge for development of effective treatment strategies for such infections.
has issue date	2020-02-03(xsd:dateTime)
bibo:doi	10.3390/antibiotics9020059
bibo:pmid	32028684
has license	cc-by
sha1sum (hex)	e5c1c652a7f7768b805977e4439939d9a2aa01e8
schema:url	https://doi.org/10.3390/antibiotics9020059
resource representing a document's title	Bacterial Biofilm and its Role in the Pathogenesis of Disease
has PubMed Central identifier	PMC7167820
has PubMed identifier	32028684
schema:publication	Antibiotics (Basel)
resource representing a document's body	covid:e5c1c652a7f7768b805977e4439939d9a2aa01e8#body_text
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