About: Microbial genomes from non-human primate gut metagenomes expand the primate-associated bacterial tree of life with over 1000 novel species

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About: Microbial genomes from non-human primate gut metagenomes expand the primate-associated bacterial tree of life with over 1000 novel species Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Microbial genomes from non-human primate gut metagenomes expand the primate-associated bacterial tree of life with over 1000 novel species
Creator	Asnicar, Francesco Bazzani, Davide Beghini, Francesco Cumbo, Fabio Karcher, Nicolai Manara, Serena Manghi, Paolo Nigro, Eleonora Pasolli, Edoardo Segata, Nicola Zolfo, Moreno Metzger, Marisa
Source	Medline; PMC
abstract	BACKGROUND: Humans have coevolved with microbial communities to establish a mutually advantageous relationship that is still poorly characterized and can provide a better understanding of the human microbiome. Comparative metagenomic analysis of human and non-human primate (NHP) microbiomes offers a promising approach to study this symbiosis. Very few microbial species have been characterized in NHP microbiomes due to their poor representation in the available cataloged microbial diversity, thus limiting the potential of such comparative approaches. RESULTS: We reconstruct over 1000 previously uncharacterized microbial species from 6 available NHP metagenomic cohorts, resulting in an increase of the mappable fraction of metagenomic reads by 600%. These novel species highlight that almost 90% of the microbial diversity associated with NHPs has been overlooked. Comparative analysis of this new catalog of taxa with the collection of over 150,000 genomes from human metagenomes points at a limited species-level overlap, with only 20% of microbial candidate species in NHPs also found in the human microbiome. This overlap occurs mainly between NHPs and non-Westernized human populations and NHPs living in captivity, suggesting that host lifestyle plays a role comparable to host speciation in shaping the primate intestinal microbiome. Several NHP-specific species are phylogenetically related to human-associated microbes, such as Elusimicrobia and Treponema, and could be the consequence of host-dependent evolutionary trajectories. CONCLUSIONS: The newly reconstructed species greatly expand the microbial diversity associated with NHPs, thus enabling better interrogation of the primate microbiome and empowering in-depth human and non-human comparative and co-diversification studies.
has issue date	2019-12-28(xsd:dateTime)
bibo:doi	10.1186/s13059-019-1923-9
bibo:pmid	31883524
has license	cc-by
sha1sum (hex)	e633cc8cbce07eacd478bb25aa824872ad55c59d
schema:url	https://doi.org/10.1186/s13059-019-1923-9
resource representing a document's title	Microbial genomes from non-human primate gut metagenomes expand the primate-associated bacterial tree of life with over 1000 novel species
has PubMed Central identifier	PMC6935492
has PubMed identifier	31883524
schema:publication	Genome Biol
resource representing a document's body	covid:e633cc8cbce07eacd478bb25aa824872ad55c59d#body_text
is schema:about of	named entity 'microbial' named entity 'METAGENOMES' named entity 'ASSOCIATED' named entity 'PRIMATE' named entity 'GUT' named entity 'POORLY' named entity 'SYMBIOSIS' named entity 'POOR' named entity 'NON-HUMAN PRIMATE' named entity 'REPRESENTATION' named entity 'RELATIONSHIP' named entity 'STUDY' named entity 'POTENTIAL' named entity 'HUMAN MICROBIOME' named entity 'APPROACH' named entity 'MICROBIAL' named entity 'HAVE' named entity 'COMMUNITIES' named entity 'ESTABLISH' named entity 'LIMITING' named entity 'HUMAN' named entity 'BACTERIAL' named entity 'TREE OF LIFE' named entity 'NON-HUMAN PRIMATE' named entity 'PROVIDE' named entity 'NHP' named entity 'SPECIES' named entity 'APPROACHES' named entity '1000' named entity 'HUMANS' named entity 'UNDERSTANDING' named entity 'GENOMES' named entity 'MICROBIAL' named entity 'BACKGROUND' named entity 'AVAILABLE' named entity 'ANALYSIS' named entity 'EXPAND' named entity 'SPECIES' named entity 'BETTER' named entity 'THEIR' named entity 'MICROBIAL DIVERSITY' named entity 'NOVEL' named entity 'CHARACTERIZED' named entity 'DUE TO' covid:arg/e633cc8cbce07eacd478bb25aa824872ad55c59d named entity 'promising' named entity 'NHP' named entity 'NHP' named entity 'human' named entity 'NHP' named entity 'microbial' named entity 'microbial' named entity 'microbiomes' named entity 'genomes' named entity 'non-human primate' named entity 'human gut microbiome' named entity 'genus' named entity 'microbiomes' named entity 'contigs' named entity 'phyla' named entity 'primate' named entity 'microbiome' named entity 'Treponema' named entity 'host species' named entity 'Pygathrix' named entity 'metagenome' named entity 'NHP' named entity 'gut microbiome' named entity 'genomes' named entity 'host-specific'

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