About: Potent inhibitors of SARS-CoV-2 3C-like protease derived from N-substituted isatin compounds

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About: Potent inhibitors of SARS-CoV-2 3C-like protease derived from N-substituted isatin compounds Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Potent inhibitors of SARS-CoV-2 3C-like protease derived from N-substituted isatin compounds
Creator	Liu, Ying Liu, Hongbo Liu, Y Lai, Luhua Li, Chunmei Liang, Hao Li, C Liu, Pei Sun, Qi Deng, X Liu, H Liu, P Lai, L Sun, Q Deng, Xiaobing Liang, H Bnlms, ‖
Source	Elsevier; Medline; PMC
abstract	SARS-CoV-2 3C-like protease is the main protease of SARS-CoV-2 and has been considered as one of the key targets for drug discovery against COVID-19. We identified several N-substituted isatin compounds as potent SARS-CoV-2 3C-like protease inhibitors. The three most potent compounds inhibit SARS-CoV-2 3C-like protease with IC(50)’s of 45 nM, 47 nM and 53 nM, respectively. Our study indicates that N-substituted isatin compounds have the potential to be developed as broad-spectrum anti-coronavirus drugs.
has issue date	2020-08-01(xsd:dateTime)
bibo:doi	10.1016/j.ejmech.2020.112702
bibo:pmid	32798789
has license	no-cc
sha1sum (hex)	e672db0dbc349b3c1a450d0643d5359ba20a0ea3
schema:url	https://doi.org/10.1016/j.ejmech.2020.112702
resource representing a document's title	Potent inhibitors of SARS-CoV-2 3C-like protease derived from N-substituted isatin compounds
has PubMed Central identifier	PMC7395831
has PubMed identifier	32798789
schema:publication	Eur J Med Chem
resource representing a document's body	covid:e672db0dbc349b3c1a450d0643d5359ba20a0ea3#body_text
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