About: Epidemiological, clinical and virological characteristics of 74 cases of coronavirus-infected disease 2019 (COVID-19) with gastrointestinal symptoms

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About: Epidemiological, clinical and virological characteristics of 74 cases of coronavirus-infected disease 2019 (COVID-19) with gastrointestinal symptoms Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Epidemiological, clinical and virological characteristics of 74 cases of coronavirus-infected disease 2019 (COVID-19) with gastrointestinal symptoms
Creator	Zhang, Xuan Zhao, Hong Liu, Jun Li, Lan-Juan Qiu, Yun-Qing Wu, Xiao-Xin Xu, Kai-Jin Yu, Liang Yang, Yida Ni, Qin Shi, Ding Zhang, Xiao-Li Zheng, Lin Jin, Gao, Jianguo Jin, Xi Ren, Yue Li, Yong-Tao Yu, Xia Chen, Yanfei Gu, Jue-Qing Hao, Shao-Rui Hu, Jian-Hua Huang, Jian-Rong Jia, Hong-Yu Jifang, Lang, Jing Lian, Jiang-Shan Lu, Ying-Feng Qv, Ting-Ting Su, Jun-Wei Tao, Jing-Jing Wang, Xiao-Yan Wu, Wen-Rui Xiang, Dai-Rong Xu, Kang-Li Ye, Chan-Yuan Yi, Ping Yu, Bo Yu, Guo-Dong Yu, Xiao-Peng Zhang, Shan-Yan Zhang, Yi-Min Zhu, Biao
source	Medline; PMC
abstract	OBJECTIVE: The SARS-CoV-2-infected disease (COVID-19) outbreak is a major threat to human beings. Previous studies mainly focused on Wuhan and typical symptoms. We analysed 74 confirmed COVID-19 cases with GI symptoms in the Zhejiang province to determine epidemiological, clinical and virological characteristics. DESIGN: COVID-19 hospital patients were admitted in the Zhejiang province from 17 January 2020 to 8 February 2020. Epidemiological, demographic, clinical, laboratory, management and outcome data of patients with GI symptoms were analysed using multivariate analysis for risk of severe/critical type. Bioinformatics were used to analyse features of SARS-CoV-2 from Zhejiang province. RESULTS: Among enrolled 651 patients, 74 (11.4%) presented with at least one GI symptom (nausea, vomiting or diarrhoea), average age of 46.14 years, 4-day incubation period and 10.8% had pre-existing liver disease. Of patients with COVID-19 with GI symptoms, 17 (22.97%) and 23 (31.08%) had severe/critical types and family clustering, respectively, significantly higher than those without GI symptoms, 47 (8.14%) and 118 (20.45%). Of patients with COVID-19 with GI symptoms, 29 (39.19%), 23 (31.08%), 8 (10.81%) and 16 (21.62%) had significantly higher rates of fever >38.5°C, fatigue, shortness of breath and headache, respectively. Low-dose glucocorticoids and antibiotics were administered to 14.86% and 41.89% of patients, respectively. Sputum production and increased lactate dehydrogenase/glucose levels were risk factors for severe/critical type. Bioinformatics showed sequence mutation of SARS-CoV-2 with m(6)A methylation and changed binding capacity with ACE2. CONCLUSION: We report COVID-19 cases with GI symptoms with novel features outside Wuhan. Attention to patients with COVID-19 with non-classic symptoms should increase to protect health providers.
has issue date	2020-03-24(xsd:dateTime)
bibo:doi	10.1136/gutjnl-2020-320926
bibo:pmid	32213556
has license	cc-by-nc
sha1sum (hex)	e6d2c030bb4bb71cae43fd29624e70872b1662a4
schema:url	https://doi.org/10.1136/gutjnl-2020-320926
resource representing a document's title	Epidemiological, clinical and virological characteristics of 74 cases of coronavirus-infected disease 2019 (COVID-19) with gastrointestinal symptoms
has PubMed Central identifier	PMC7133387
has PubMed identifier	32213556
schema:publication	Gut
resource representing a document's body	covid:e6d2c030bb4bb71cae43fd29624e70872b1662a4#body_text
is schema:about of	named entity 'Gut' named entity 'CHARACTERISTICS' named entity 'GASTROINTESTINAL SYMPTOMS' named entity 'YEAR' named entity 'GUT' named entity 'VIROLOGICAL' named entity 'INFECTED' named entity 'CASES' named entity 'EPIDEMIOLOGICAL' named entity 'DISEASE' named entity 'CLINICAL' named entity 'CITE' named entity 'INCLUDE' named entity 'MONTH' named entity '2019' named entity 'CORONAVIRUS' named entity 'PRINT' named entity 'DAY' named entity 'virological' named entity 'COVID-19' named entity 'coronavirus' named entity 'Epidemiological' named entity 'symptom' named entity 'COVID' named entity 'host cells' named entity 'COVID' named entity 'Wuhan' named entity 'renal failure' named entity 'virus' named entity 'China' named entity 'COVID' named entity 'electrolyte imbalance' named entity 'COVID' named entity 'symptom' named entity 'Wuhan' named entity 'viruses' named entity 'mutation' named entity 'intensive care unit'

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