About: Counter-regulatory renin–angiotensin system in cardiovascular disease

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Counter-regulatory renin–angiotensin system in cardiovascular disease Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Counter-regulatory renin–angiotensin system in cardiovascular disease
Creator	Chiong, Mario Lavandero, Sergio Jalil, Jorge Santos, Robson García, Lorena Ocaranza, Maria Riquelme, Jaime
source	Medline; PMC
abstract	The renin–angiotensin system is an important component of the cardiovascular system. Mounting evidence suggests that the metabolic products of angiotensin I and II — initially thought to be biologically inactive — have key roles in cardiovascular physiology and pathophysiology. This non-canonical axis of the renin–angiotensin system consists of angiotensin 1–7, angiotensin 1–9, angiotensin-converting enzyme 2, the type 2 angiotensin II receptor (AT(2)R), the proto-oncogene Mas receptor and the Mas-related G protein-coupled receptor member D. Each of these components has been shown to counteract the effects of the classical renin–angiotensin system. This counter-regulatory renin–angiotensin system has a central role in the pathogenesis and development of various cardiovascular diseases and, therefore, represents a potential therapeutic target. In this Review, we provide the latest insights into the complexity and interplay of the components of the non-canonical renin–angiotensin system, and discuss the function and therapeutic potential of targeting this system to treat cardiovascular disease.
has issue date	2019-08-19(xsd:dateTime)
bibo:doi	10.1038/s41569-019-0244-8
bibo:pmid	31427727
has license	no-cc
sha1sum (hex)	e6d567a261b5a3967c0ea0e54680000f13fb5fb7
schema:url	https://doi.org/10.1038/s41569-019-0244-8
resource representing a document's title	Counter-regulatory renin–angiotensin system in cardiovascular disease
has PubMed Central identifier	PMC7097090
has PubMed identifier	31427727
schema:publication	Nat Rev Cardiol
resource representing a document's body	covid:e6d567a261b5a3967c0ea0e54680000f13fb5fb7#body_text
is schema:about of	named entity 'MAS' named entity 'PROTO-ONCOGENE MAS' named entity 'PROVIDE' named entity 'ANGIOTENSIN I' named entity 'BIOLOGICALLY' named entity 'RENIN-ANGIOTENSIN SYSTEM' named entity 'AXIS' named entity 'REGULATORY' named entity 'POTENTIAL' named entity 'PATHOGENESIS' named entity 'EVIDENCE' named entity 'NON-' named entity 'EFFECTS' named entity 'MOUNTING' named entity 'FUNCTION' named entity '2 ANGIOTENSIN' named entity 'IMPORTANT' named entity 'PATHOPHYSIOLOGY' named entity 'ROLE' named entity 'CARDIOVASCULAR SYSTEM' named entity 'CLASSICAL' named entity 'INACTIVE' named entity 'CENTRAL' named entity 'SYSTEM' named entity 'REVIEW' named entity 'TARGETING' named entity 'ANGIOTENSIN-CONVERTING ENZYME 2' named entity 'TYPE 2' named entity 'ANGIOTENSIN II RECEPTOR' named entity 'THERAPEUTIC TARGET' named entity 'THERAPEUTIC' named entity 'CARDIOVASCULAR DISEASES' named entity 'PRODUCTS' named entity 'MAS RECEPTOR' named entity 'CARDIOVASCULAR DISEASE' named entity 'TREAT' named entity 'ANGIOTENSIN 1-7' named entity 'DISCUSS' named entity 'COUNTER' named entity 'RELATED' named entity 'G PROTEIN-COUPLED RECEPTOR' named entity 'ROLES' named entity 'DEVELOPMENT' named entity 'RENIN-ANGIOTENSIN SYSTEM' named entity 'REGULATORY' named entity 'MEMBER' named entity 'KEY' named entity 'LATEST' named entity 'METABOLIC' named entity 'CARDIOVASCULAR DISEASE' named entity 'VARIOUS' named entity 'INSIGHTS' named entity 'COMPONENTS' named entity 'COMPONENT' named entity 'COMPLEXITY' named entity 'THESE' named entity 'COUNTER' named entity 'HAVE' named entity 'THOUGHT' named entity 'CARDIOVASCULAR PHYSIOLOGY' named entity 'ANGIOTENSIN 1-9' named entity 'angiotensin' named entity 'This' named entity 'renin-angiotensin system' named entity 'renin-angiotensin system' named entity 'Review' named entity 'renin-angiotensin system' named entity 'angiotensin-converting enzyme 2' named entity 'receptor' named entity 'cardiovascular disease' named entity 'cardiovascular' named entity 'renin-angiotensin' named entity 'receptor' named entity 'proto-oncogene' named entity 'renin-angiotensin'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software