About: Medication adherence to first-line antihypertensive drug class in a large Chinese population

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Medication adherence to first-line antihypertensive drug class in a large Chinese population
Creator	Tam, Wilson Griffiths, Sian Leeder, Stephen Wong, Martin Cheung, Clement Cheung, N Sek, Antonio Tong, Ellen
Source	Elsevier; Medline; PMC
abstract	Abstract Purpose Suboptimal adherence to antihypertensive agents leads to adverse clinical outcomes. This study aims to evaluate the association between first-line antihypertensive drug class and medication adherence in a large Chinese population. Methods All patients prescribed ≥ one antihypertensive drug in 2001–2003 and 2005 who have paid at least two consecutive clinic visits in the public healthcare system of Hong Kong were included. We excluded patients who have followed-up in the clinics for ≤30days. Interval-based Proportion of Days Covered (PDC) was used to assess medication adherence. All patients were followed-up for up to 5years. Binary logistic regression analysis was used to evaluate the factors associated with optimal adherence, defined as PDC ≥80%. Results From 147,914 eligible patients, 69.2% were adherent to the antihypertensive prescriptions. When compared with angiotensin converting enzyme inhibitors (ACEIs), patients initially prescribed α-blockers (adjusted odds ratio [AOR]=0.234, 95% C.I. 0.215–0.256), β-blockers (AOR=0.447, 95% C.I. 0.420, 0.477), thiazide diuretics (AOR=0.431 95% C.I. 0.399, 0.466) and calcium channel blockers (AOR=0.451, 95% C.I. 0.423, 0.481) were significantly less likely to be drug adherers. Angiotensin receptor blockers (ARBs) and fixed-dose combination therapies were similarly likely to be medication adherent. Older age, male gender, visits in general out-patient clinics, residence in urbanized regions, and the presence of comorbidity were positively associated with optimal drug adherence. Conclusion Patients receiving initial prescriptions of ACEIs, ARB and combination therapy had more favorable adherence profiles than the other major antihypertensive classes in real-life clinical practice.
has issue date	2013-08-20(xsd:dateTime)
bibo:doi	10.1016/j.ijcard.2012.04.060
bibo:pmid	22560948
has license	els-covid
sha1sum (hex)	e6e35c08477e686107dd7930313221e54e9a60e9
schema:url	https://doi.org/10.1016/j.ijcard.2012.04.060
resource representing a document's title	Medication adherence to first-line antihypertensive drug class in a large Chinese population
has PubMed Central identifier	PMC7132368
has PubMed identifier	22560948
schema:publication	International Journal of Cardiology
resource representing a document's body	covid:e6e35c08477e686107dd7930313221e54e9a60e9#body_text
is schema:about of	named entity 'When' named entity 'gender' named entity 'drug' named entity 'age' named entity 'drug' named entity 'This' named entity 'antihypertensive' named entity 'C.I.' named entity 'inhibitors' named entity 'INITIALLY' named entity 'LARGE' named entity 'CLINIC' named entity 'ADHERENCE' named entity 'OUT-PATIENT' named entity 'ADHERENT' named entity 'OPTIMAL' named entity 'ASSOCIATED WITH' named entity 'ASSESS' named entity 'ANGIOTENSIN RECEPTOR BLOCKERS' named entity 'SUBOPTIMAL' named entity 'ANGIOTENSIN CONVERTING ENZYME INHIBITORS' named entity '0.215' named entity 'EVALUATE' named entity 'ANTIHYPERTENSIVE DRUG' named entity 'YEARS' named entity 'THIAZIDE DIURETICS' named entity 'COMORBIDITY' named entity 'CALCIUM CHANNEL BLOCKERS' named entity 'PRESCRIBED' named entity 'INTERVAL' named entity 'COVERED' named entity 'CHINESE' named entity 'POPULATION' named entity 'DRUG' named entity 'FAVORABLE' named entity 'ARB' named entity 'PRESCRIPTIONS' named entity 'CLASS' named entity 'COMBINATION THERAPY' named entity 'CONCLUSION' named entity 'ASSOCIATION' named entity 'RECEIVING' named entity 'MEDICATION ADHERENCE' named entity 'PUBLIC HEALTHCARE' named entity 'HONG KONG' named entity 'RESIDENCE' named entity 'PAID' named entity 'MAJOR' named entity 'DEFINED' named entity 'DOSE' named entity '234' named entity 'PDC' named entity 'PATIENTS' named entity 'LEADS' named entity 'LOGISTIC REGRESSION ANALYSIS' named entity 'UP TO' named entity 'PROPORTION' named entity 'LINE' named entity 'CLASSES' named entity 'HEALTHCARE SYSTEM' named entity 'ELIGIBLE' named entity 'REGIONS' named entity 'CLINICAL OUTCOMES' named entity 'OLDER AGE' named entity 'STUDY' named entity 'DAYS' named entity 'INCLUDED' named entity 'ODDS RATIO' named entity 'CLINICS' named entity '420' named entity 'FOLLOWED' named entity '80%' named entity 'LIFE' named entity '466'

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