About: The Heart in COVID19: Primary Target or Secondary Bystander?

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The Heart in COVID19: Primary Target or Secondary Bystander?
Creator	Libby, Peter
Source	Elsevier; Medline; PMC
abstract	Summary: In the throes of the current COVID-19 pandemic, interest has burgeoned in the cardiovascular complications of this virulent viral infection. As troponin, a biomarker of cardiac injury, often rises in hospitalized patients, its interpretation and actionability require careful consideration. Fulminant myocarditis due to direct viral infection can certainly occur, but patients with increased oxygen demands due to tachycardia and fever, and reduced oxygen delivery due to hypotension and hypoxemia can cause myocardial injury indirectly. Cytokines released during the acute infection can elicit activation of cells within pre-existing atherosclerotic lesions, augmenting thrombotic risk and risk of ischemic syndromes. Moreover, microvascular activation by cytokines can cause not only myocardial injury but harm other organ systems commonly involved in COVID-19 infections including the kidneys. Dealing with the immense challenge of COVID-19 disease, confronted with severely ill patients in dire straits with virtually no rigorous evidence base to guide our therapy, we must call upon our clinical skills and judgment. These touchstones can help guide us in selecting patients who might benefit from the advanced imaging and invasive procedures that present enormous logistical challenges in the current context. Lacking a robust evidence base, pathophysiologic reasoning can help guide our choices of therapy for individual clinical scenarios. We must exercise caution and extreme humility, as often plausible interventions fail when tested rigorously. But act today we must, and understanding the multiplicity of mechanisms of myocardial injury in COVID-19 infection will help us meet our mission unsupported by the comfort of strong data.
has issue date	2020-04-10(xsd:dateTime)
bibo:doi	10.1016/j.jacbts.2020.04.001
bibo:pmid	32292847
has license	els-covid
sha1sum (hex)	e6eefd34cd7466463ab20f15d56ff5ef6e9a7bcc
schema:url	https://doi.org/10.1016/j.jacbts.2020.04.001
resource representing a document's title	The Heart in COVID19: Primary Target or Secondary Bystander?
has PubMed Central identifier	PMC7151324
has PubMed identifier	32292847
schema:publication	JACC Basic Transl Sci
resource representing a document's body	covid:e6eefd34cd7466463ab20f15d56ff5ef6e9a7bcc#body_text
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