About: Hypertension in patients hospitalized with COVID-19 in Wuhan, China: A single-center retrospective observational study

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About: Hypertension in patients hospitalized with COVID-19 in Wuhan, China: A single-center retrospective observational study Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Hypertension in patients hospitalized with COVID-19 in Wuhan, China: A single-center retrospective observational study
Creator	Zhang, Yuan Wu, Feng Li, Haijun Chen, Zhongqing Huang, Qiaobing Han, Jiafa Hu, Hongbin Song, Wenhong Tong, Sha Zeng, Zhenhua A#, M B#, M Sha, Tong
Source	MedRxiv
abstract	Objectives: It is unclear whether patients with hypertension are more likely to be infected with SARS-COV-2 than the general population and whether there is a difference in the severity of COVID-19 pneumonia in patients who have taken ACEI/ARB drugs to lower blood pressure compared to those who have not. Methods: This observational study included data from all patients with clinically confirmed COVID-19 who were admitted to the Hankou Hospital, Wuhan, China between January 5 and March 8, 2020. Data were extracted from clinical and laboratory records. Follow-up was cutoff on March 8, 2020. Results: A total of 274 patients, 75 with hypertension and 199 without hypertension, were included in the analysis. Patients with hypertension were older and were more likely to have pre-existing comorbidities, including chronic renal insufficiency, cardiovascular disease, diabetes mellitus, and cerebrovascular disease than patients without hypertension. Moreover, patients with hypertension tended to have higher positive COVID-19 PCR detection rates. Patients with hypertension who had previously taken ACEI/ARB drugs for antihypertensive treatment have an increased tendency to develop severe pneumonia after infection with SARS-COV-2 (P = 0.064). Conclusions: COVID-19 patients with hypertension were significantly older and were more likely to have underlying comorbidities, including chronic renal insufficiency, cardiovascular disease, diabetes mellitus, and cerebrovascular disease. Patients with hypertension who had taken ACEI/ARB drugs for antihypertensive treatment have an increased tendency to develop severe pneumonia after infection with SARS-COV-2. In future studies, a larger sample size and multi-center clinical data will be needed to support our conclusions.
has issue date	2020-04-11(xsd:dateTime)
bibo:doi	10.1101/2020.04.06.20054825
has license	medrxiv
sha1sum (hex)	e704299cf656743be4a8943612c55bb3f437d467
schema:url	https://doi.org/10.1101/2020.04.06.20054825
resource representing a document's title	Hypertension in patients hospitalized with COVID-19 in Wuhan, China: A single-center retrospective observational study
resource representing a document's body	covid:e704299cf656743be4a8943612c55bb3f437d467#body_text
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