About: Circulating endothelial progenitors are increased in Covid‐19 patients and correlate with SARS‐CoV‐2 RNA in severe cases

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About: Circulating endothelial progenitors are increased in Covid‐19 patients and correlate with SARS‐CoV‐2 RNA in severe cases Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Circulating endothelial progenitors are increased in Covid‐19 patients and correlate with SARS‐CoV‐2 RNA in severe cases
Creator	Cremonesi, Paola Rusconi, Stefano Bertolini, Francesco Caccia, Sonia Cogliati, Chiara Giacomelli, Andrea Gidaro, Antonio Gregato, Giuliana Gusso, Luca Mancuso, Patrizia Quarna, Jessica Raveane, Alessandro
Source	Medline; PMC
abstract	BACKGROUND: During the course of Covid‐19, the disease caused by the new Coronavirus SARS‐CoV‐2, thrombotic phenomena and/or diffuse vascular damage are frequent, and viral elements have been observed within endothelial cells. OBJECTIVES: CD146+ circulating endothelial cells (CD146+ CECs) and their progenitors (CEPs) are increased in cardiovascular, thrombotic, infectious and cancer diseases. The present study was designed to investigate their kinetics in Covid‐19 patients. METHOD: We used a validated flow cytometry procedure to enumerate viable and apoptotic CD146+ CECs and CEPs in Covid‐19 patients during the course of the disease and in patients who recovered. RESULT: Viable CEPs/mL were significantly increased in Covid‐19 patients compared to healthy controls. This increase was observed in patients with mild symptoms and not further augmented in patients with severe symptoms. In patients who recovered, CEPs decreased, but were in a range still significantly higher than normal controls. Regarding mature CD146+ CECs, in Covid‐19 patients their absolute number was similar to those observed in healthy controls, but the viable/apoptotic CD146+ CEC ratio was significantly different. Both mild and severe Covid‐19 patients had significantly less apoptotic CD146+ CECs compared to healthy controls. Patients who recovered had significantly less CD146+ CECs/mL when compared to controls as well as to mild and severe Covid‐19 patients. A positive correlation was found between the copies of SARS‐CoV‐2 RNA in the cellular fraction and apoptotic CEPs/mL in severe Covid‐19 patients. CONCLUSIONS: CD146+ CECs and CEPs might be investigated as candidate biomarkers of endothelial damage in Covid‐19 patients.
has issue date	2020-08-06(xsd:dateTime)
bibo:doi	10.1111/jth.15044
bibo:pmid	32762140
has license	no-cc
sha1sum (hex)	e7151981430c0e88c2941210877ade3fb0bc82f8
schema:url	https://doi.org/10.1111/jth.15044
resource representing a document's title	Circulating endothelial progenitors are increased in Covid‐19 patients and correlate with SARS‐CoV‐2 RNA in severe cases
has PubMed Central identifier	PMC7436444
has PubMed identifier	32762140
schema:publication	J Thromb Haemost
resource representing a document's body	covid:e7151981430c0e88c2941210877ade3fb0bc82f8#body_text
is schema:about of	named entity 'endothelial' named entity 'severe acute respiratory syndrome coronavirus 2' named entity 'apoptotic' named entity 'severe' named entity 'Covid' named entity 'RNA' named entity 'vascular diseases' named entity 'peripheral blood' named entity 'apoptotic' named entity 'viremia' named entity 'Covid' named entity 'clinical trials' named entity 'apoptotic' named entity 'CD146' named entity 'monoclonal antibodies' named entity 'IL-6' named entity 'positive correlation' named entity 'Qiagen' named entity 'Covid-19' named entity 'hematocrit' named entity 'CD146' named entity 'p<0.01' named entity 'eosinophils' named entity 'thrombotic' named entity 'COVID' named entity 'cardiovascular diseases' named entity 'red blood cell' named entity 'peripheral blood' named entity 'nucleic acid' named entity 'RT-PCR' named entity 'hemoglobin' named entity 'SARS-CoV' named entity 'apoptotic' named entity 'thrombotic' named entity 'white adipose tissue' named entity 'apoptotic' named entity 'Covid' named entity 'Covid' named entity 'Covid-19' named entity 'neoplastic' named entity 'Eisai' named entity 'apoptotic' named entity 'Covid-19' named entity 'normality test' named entity 'Covid' named entity 'RNA' named entity 'apoptotic' named entity 'Flow cytometry' named entity 'endothelial' named entity '21%' named entity 'leukocyte count' named entity 'RNA' named entity 'positive correlation' named entity 'SARS-CoV-2' named entity 'lymphocytes' named entity 'preclinical models' named entity '2020 coronavirus' named entity 'hemoglobin' named entity 'April 2020' named entity 'Github' named entity 'kidney' named entity 'Covid' named entity 'apoptotic' named entity 'Apoptotic' named entity 'Covid-19' named entity 'ferritin' named entity 'lungs' named entity 'Normal distribution' named entity 'CD146' named entity 'apoptotic'

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