About: Characterization of Stool Virome in Children Newly Diagnosed With Moderate to Severe Ulcerative Colitis

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About: Characterization of Stool Virome in Children Newly Diagnosed With Moderate to Severe Ulcerative Colitis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Characterization of Stool Virome in Children Newly Diagnosed With Moderate to Severe Ulcerative Colitis
Creator	Tokarz, Rafal Che, Xiaoyu Sameroff, Stephen Lee, Bohyun Baker, Susan Lipkin, W Mack, David Baldassano, Robert Boyle, Brendan Denson, Lee Griffiths, Anne Hyams, Jeffrey Kugathasan, Subra Leleiko, Neal Markowitz, James Oleynik, Alexandra Rosh, Joel Sauer, Cary Shah, Sapana Tagliafierro, Teresa Walters, Thomas
Source	PMC
abstract	BACKGROUND: Viral infections have been suggested as possible triggers for the onset of ulcerative colitis (UC). METHODS: We employed VirCapSeq-Vert, a high-throughput sequencing virus capture platform, to examine the stool virome of children with newly diagnosed moderate to severe UC. We surveyed fecal samples collected at presentation, after symptom remission, and from a control group diagnosed with irritable bowel syndrome. RESULTS: Seventy subjects with UC (mean age 13 years, 45 had moderate symptoms, 25 had severe, 69 of 70 had a Mayo endoscopy subscore 2/3) were studied. We detected a wide range of animal viruses that were taxonomically classified into 12 viral families. A virus was present in 50% of fecal samples collected at presentation, 41% of samples collected after remission, and 40% of samples in our control group. The most frequently identified viruses were diet-based gyroviruses. The UC cohort had a significantly higher prevalence of anelloviruses compared with the control cohort. However, we did not identify a single virus that can be implicated in the onset of UC and did not find an association between UC disease severity and viral presence. CONCLUSION: Presence of virus in stool was not associated with the onset of pediatric UC.
has issue date	2019-05-21(xsd:dateTime)
bibo:doi	10.1093/ibd/izz099
bibo:pmid	31112614
has license	no-cc
sha1sum (hex)	e765010985191b3594f6e3e29028d330a5e7f45c
schema:url	https://doi.org/10.1093/ibd/izz099
resource representing a document's title	Characterization of Stool Virome in Children Newly Diagnosed With Moderate to Severe Ulcerative Colitis
has PubMed Central identifier	PMC7108593
has PubMed identifier	31112614
schema:publication	Inflamm Bowel Dis
resource representing a document's body	covid:e765010985191b3594f6e3e29028d330a5e7f45c#body_text
is schema:about of	named entity 'ULCERATIVE COLITIS' named entity 'MODERATE TO SEVERE' named entity 'presentation' named entity 'Methods' named entity 'employed' named entity 'symptom' named entity 'samples' named entity 'PRESENTATION' named entity 'NEWLY DIAGNOSED' named entity 'CAPTURE' named entity 'VIRUS' named entity 'PLATFORM' named entity 'SYMPTOM REMISSION' covid:arg/e765010985191b3594f6e3e29028d330a5e7f45c named entity 'VIRAL INFECTIONS' named entity 'FECAL' named entity 'TRIGGERS' named entity 'MODERATE TO SEVERE' named entity 'COLLECTED' named entity 'IRRITABLE BOWEL SYNDROME' named entity 'METHODS' named entity 'CHILDREN' named entity 'EMPLOYED' named entity 'STOOL' named entity 'STOOL' named entity 'CONTROL GROUP' named entity 'CHARACTERIZATION' named entity 'HAVE' named entity 'BACKGROUND' named entity 'NEWLY DIAGNOSED' named entity 'ULCERATIVE COLITIS' named entity 'DIAGNOSED' named entity 'HIGH-THROUGHPUT SEQUENCING' named entity 'ONSET OF' named entity 'SAMPLES' named entity 'CHILDREN' named entity 'VIRCAPSEQ-VERT' named entity 'POSSIBLE' named entity 'TO EXAMINE' named entity 'ulcerative colitis' named entity 'study population' named entity 'link function' named entity 'anellovirus' named entity 'triggers' named entity 'fecal' named entity 'high-throughput sequencing' named entity 'irritable bowel syndrome' named entity 'ulcerative colitis' named entity 'symptom' named entity 'control group' named entity 'Data analysis' named entity 'enterovirus' named entity 'noroviruses' named entity 'viruses' named entity 'Herpesviruses' named entity 'Norovirus' named entity 'Saffold virus' named entity 'Illumina' named entity 'adenovirus' named entity 'endoscopic' named entity 'Bowtie2'

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