About: COVID‐19 in elderly kidney transplant recipients

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About: COVID‐19 in elderly kidney transplant recipients Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	COVID‐19 in elderly kidney transplant recipients
Creator	Barrios, Clara Pascual, Julio Collado, Silvia Crespo, Marta Horcajada, Juan Barbosa, Francesc José Pérez-Sáez, María Llinàs-Mallol, Laura Redondo-Pachón, Dolores Arenas, Dolores Arias-Cabrales, Carlos Burballa, Carla Buxeda, Anna Cao, Higini Cat, Cat, Marta Crespo, -Mcrespo@psmar Güerri-Fernández, Roberto López, Thais Mir, Marisa Montero, María Moreno, Fátima Outón, Sara Pascual -Jpascual@psmar, Julio Rodríguez, Eva Sans, Laia Sierra, Adriana Villar, Judith Vázquez, Susana
Source	Medline; PMC
abstract	The SARS‐Cov‐2 infection disease (COVID‐19) pandemic has posed at risk the kidney transplant (KT) population, particularly the elderly recipients. From March‐12(th) until April‐4(th) 2020, we diagnosed COVID‐19 in 16 of our 324 KT patients aged ≥65 years old (4.9%). Many of them had had contact with healthcare facilities in the month prior to infection. Median time of symptom onset to admission was 7 days. All presented with fever and all but one with pneumonia. Up to 33% showed renal graft dysfunction. At infection diagnosis, mTOR inhibitors or mycophenolate were withdrawn. Tacrolimus was withdrawn in 70%. The main treatment combination was hydroxychloroquine and azithromycin. A subset of patients was treated with anti‐retroviral and tocilizumab. Short‐term fatality rate was 50% at a median time since admission of 3 days. Those who died were more frequently obese, frail and had underlying heart disease. Although a higher respiratory rate was observed at admission in nonsurvivors, symptoms at presentation were similar between both groups. Patients who died were more anemic, lymphopenic and showed higher D‐dimer, C‐reactive protein, and IL‐6 at their first tests. COVID‐19 is frequent among the elderly KT population and associates a very early and high mortality rate.
has issue date	2020-05-29(xsd:dateTime)
bibo:doi	10.1111/ajt.16096
bibo:pmid	32471001
has license	no-cc
sha1sum (hex)	e766fb5dab17c6a25ed747c384bd62c045cc5472
schema:url	https://doi.org/10.1111/ajt.16096
resource representing a document's title	COVID‐19 in elderly kidney transplant recipients
has PubMed Central identifier	PMC7301011
has PubMed identifier	32471001
schema:publication	Am J Transplant
resource representing a document's body	covid:e766fb5dab17c6a25ed747c384bd62c045cc5472#body_text
is schema:about of	named entity 'TREATMENT' named entity 'POPULATION' named entity 'SUBSET' named entity 'MAIN' named entity 'FREQUENTLY' named entity '324' named entity 'RETROVIRAL' named entity 'TIME OF SYMPTOM ONSET' named entity 'KIDNEY TRANSPLANT' named entity 'OLD' named entity 'PNEUMONIA' named entity 'infection' named entity 'Median' named entity 'presented' named entity 'fatality rate' named entity 'graft' named entity 'admission' named entity 'heart disease' named entity 'April' named entity 'azithromycin' named entity 'COVID-19' named entity 'hydroxychloroquine' named entity 'T-cell' named entity 'Spain' named entity '7 days' named entity 'COVID-19' named entity 'azithromycin' named entity 'hydroxychloroquine' named entity 'Tacrolimus' named entity 'fever' named entity 'COVID' named entity 'kidney transplant' named entity 'COVID-19' named entity 'interquartile range' named entity 'azithromycin' named entity 'anemia' named entity 'infection' named entity '28 days' named entity 'COVID-19' named entity 'respiratory failure' named entity 'kidney transplantation' named entity 'infection' named entity 'ICU' named entity 'malignant' named entity 'COVID-19 pandemic' named entity 'D-dimer' named entity 'COVID-19' named entity 'diabetics' named entity 'AKI' named entity 'tocilizumab' named entity 'intubation' named entity 'reverse-transcriptase' named entity 'COVID-19'

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