About: Nasal Cytokine Profiles of Patients Hospitalised with Respiratory Wheeze Associated with Rhinovirus C

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About: Nasal Cytokine Profiles of Patients Hospitalised with Respiratory Wheeze Associated with Rhinovirus C Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Nasal Cytokine Profiles of Patients Hospitalised with Respiratory Wheeze Associated with Rhinovirus C
Creator	Sikazwe, Chisha Smith, David Laing, Ingrid Imrie, Allison
source	PMC
abstract	Background: Rhinovirus C is an important pathogen of asthmatic and non-asthmatic children hospitalised with episodic wheeze. Previous studies on other respiratory viruses have shown that several host cytokines correlate with duration of hospitalisation, but this has yet to be investigated in children with RV-C infection. We determined the nasal cytokine profiles of these children and investigated their relationship with RV-C load and clinical outcome. Flocked nasal swabs were collected from children aged 24–72 months presenting to the Emergency Department at Princess Margaret Hospital with a clinical diagnosis of acute wheeze and an acute upper respiratory tract viral infection. RV-C load was determined by quantitative RT-PCR and cytokine profiles were characterised by a commercial human cytokine 34-plex panel. RV-C was the most commonly detected virus in pre-school-aged children hospitalised with an episodic wheeze. RV-C load did not significantly differ between asthmatic and non-asthmatic patients. Both groups showed a Th2-based cytokine profile. However, Th17 response cytokines IL-17 and IL-1β were only elevated in RV-C-infected children with pre-existing asthma. Neither RV-C load nor any specific cytokines were associated illness severity in this study. Medically attended RV-C-induced wheeze is characterised by a Th2 inflammatory pattern, independent of viral load. Any therapeutic interventions should be aimed at modulating the host response following infection.
has issue date	2019-11-07(xsd:dateTime)
bibo:doi	10.3390/v11111038
bibo:pmid	31703379
has license	cc-by
sha1sum (hex)	e7742497150bd3dc1d60ff914d1c0fb05f747a1a
schema:url	https://doi.org/10.3390/v11111038
resource representing a document's title	Nasal Cytokine Profiles of Patients Hospitalised with Respiratory Wheeze Associated with Rhinovirus C
has PubMed Central identifier	PMC6893661
has PubMed identifier	31703379
schema:publication	Viruses
resource representing a document's body	covid:e7742497150bd3dc1d60ff914d1c0fb05f747a1a#body_text
is schema:about of	named entity 'wheeze' named entity 'cytokines' named entity 'attended' named entity 'based' named entity 'acute' named entity 'load' named entity 'QUANTITATIVE RT-PCR' named entity 'LOAD' named entity 'NASAL' named entity 'DETERMINED' named entity 'ELEVATED' named entity 'DID' named entity 'VIRAL INFECTION' named entity 'RELATIONSHIP' named entity 'INVESTIGATED' named entity 'ASSOCIATED WITH' named entity 'PATIENTS' named entity 'THESE' named entity 'TH17' named entity 'MARGARET' named entity 'GROUPS' named entity 'IL-1' named entity 'THERAPEUTIC INTERVENTIONS' named entity 'CYTOKINE ' named entity 'STUDY' named entity 'ACUTE' named entity 'PREVIOUS' named entity 'HOSPITALISATION' named entity 'INFECTION' named entity 'CHILDREN' named entity 'RHINOVIRUS C' named entity 'NASAL SWABS' named entity 'CYTOKINES' named entity 'PATTERN' named entity 'COMMERCIAL' named entity 'HOST RESPONSE' named entity 'ILLNESS SEVERITY' named entity 'CYTOKINE PROFILE' named entity 'INFLAMMATORY' named entity 'WHEEZE' named entity 'RESPIRATORY' named entity 'CYTOKINE ' named entity 'RHINOVIRUS C' named entity 'OUTCOME' named entity 'ASTHMATIC' named entity 'CLINICAL DIAGNOSIS' named entity 'VIRAL LOAD' named entity 'HOSPITAL' named entity 'SPECIFIC' named entity 'PRE-SCHOOL' named entity 'VIRUS' named entity 'PATHOGEN' named entity 'FOLLOWING' named entity 'UPPER RESPIRATORY TRACT' named entity 'PRE-EXISTING' named entity 'COLLECTED' named entity 'WHEEZE' named entity 'ASTHMA' named entity 'PRESENTING' named entity 'NON-' named entity 'NASAL' named entity 'THEIR' named entity 'RESPIRATORY VIRUSES' named entity 'BACKGROUND' named entity 'BASED' named entity 'RESPONSE' named entity 'IMPORTANT' named entity 'IL-17' named entity 'EMERGENCY DEPARTMENT' named entity 'EPISODIC' named entity 'INDEPENDENT OF' named entity 'NEITHER' named entity 'PRINCESS' named entity 'DETECTED' named entity 'MONTHS' named entity 'ASSOCIATED' named entity 'INFECTED' named entity 'HUMAN'

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